PMID- 32392996
OWN - NLM
STAT- MEDLINE
DCOM- 20200721
LR  - 20200721
IS  - 0376-2491 (Print)
IS  - 0376-2491 (Linking)
VI  - 100
IP  - 18
DP  - 2020 May 12
TI  - [Efficacy and safety of low-intensity pulsed ultrasound at different intervals by 
      mechanical force in treating erectile dysfunction: a preliminary study].
PG  - 1432-1436
LID - 10.3760/cma.j.cn112137-20191207-02679 [doi]
AB  - Objective: To study the efficacy and safety of low-intensity pulsed ultrasound 
      (LIPUS) at different intervals by mechanical force in treating erectile 
      dysfunction (ED). Method: Forty patients with mild to moderate ED were randomized 
      in a 1ratio1 ratio to receive 16-treatment sessions of LIPUS in group A and group B, 
      applied 3 times per week and 2 times per week, respectively. End-point 
      assessments were made at 8th week after treatment. Efficacy were evaluated using 
      International Index of Erectile Function-Erectile Function domain score 
      (IIEF-EF), Erectile Hardness Score (EHS), Self-Esteem and Relationship 
      Questionnaire (SEAR), Sexual Encounter Profile (SEP), Global Assessment Question 
      (GAQ), and pain were assessed by Visual Analogue Score (VAS).Treatment response 
      was confirmed by a minimal clinically importance difference (MCID) at 8th week. 
      Results: Compared with baseline, IIEF-EF score [(17.1+/-5.48 vs 23.4+/-3.75, P<0.05) 
      and (18.9+/-4.34 vs 24.1+/-4.32, P<0.05)], proportion of EHS 4 [(0 vs 40%, P<0.05) 
      and (16.7% vs 55.6%, P<0.05)], and Overall Relationship score [(50.6 vs 67.5, 
      P<0.05) and (44.4 vs 70.1, P<0.05)] were significantly improved at 8th week in 
      two groups, respectively. Compared with baseline, the positive responses to SEP-3 
      increased significantly at 8th week in two groups (50.0% vs 80.0%,P<0.05) and 
      (44.4% vs 88.9%, P<0.05), respectively. The positive responses to GAQ-2 were 
      90.0% and 88.9% at 8th week in two groups, respectively. There were no 
      significant differences in IIEF-EF, EHS, SEAR, SEP and GAQ at 8th week between 
      two groups. There was no significant difference in treatment response using MCID 
      between two groups at end-point (80.5% vs 77.5%). The treatment duration for full 
      sessions were 2.5 weeks less in group A than group B. No adverse effects were 
      reported in all cases. Conclusion: LIPUS at two different intervals is effective 
      and safe for mild to moderate ED, and the regimen at 3 times per week can achieve 
      quite good effect in relatively short duration,while the long-term effects is 
      still be clarified in further study.
FAU - Xia, S J
AU  - Xia SJ
AD  - Urologic Medical Center, Institute of Urology, Shanghai General Hospital, 
      Shanghai Jiao Tong University, Shanghai 200080, China.
FAU - Chen, H R
AU  - Chen HR
AD  - Urologic Medical Center, Institute of Urology, Shanghai General Hospital, 
      Shanghai Jiao Tong University, Shanghai 200080, China.
FAU - Li, Z
AU  - Li Z
AD  - Urologic Medical Center, Institute of Urology, Shanghai General Hospital, 
      Shanghai Jiao Tong University, Shanghai 200080, China.
FAU - Li, X C
AU  - Li XC
AD  - Clinical Research Center, Shanghai General Hospital, Shanghai 200080, China.
FAU - Zhi, E L
AU  - Zhi EL
AD  - Urologic Medical Center, Institute of Urology, Shanghai General Hospital, 
      Shanghai Jiao Tong University, Shanghai 200080, China.
FAU - Tian, R H
AU  - Tian RH
AD  - Urologic Medical Center, Institute of Urology, Shanghai General Hospital, 
      Shanghai Jiao Tong University, Shanghai 200080, China.
FAU - Li, P
AU  - Li P
AD  - Urologic Medical Center, Institute of Urology, Shanghai General Hospital, 
      Shanghai Jiao Tong University, Shanghai 200080, China.
FAU - Huang, Y H
AU  - Huang YH
AD  - Urologic Medical Center, Institute of Urology, Shanghai General Hospital, 
      Shanghai Jiao Tong University, Shanghai 200080, China.
FAU - Hu, J L
AU  - Hu JL
AD  - Urologic Medical Center, Institute of Urology, Shanghai General Hospital, 
      Shanghai Jiao Tong University, Shanghai 200080, China.
FAU - Qiu, Y
AU  - Qiu Y
AD  - Clinical Research Center, Shanghai General Hospital, Shanghai 200080, China.
LA  - chi
PT  - Journal Article
PT  - Randomized Controlled Trial
PL  - China
TA  - Zhonghua Yi Xue Za Zhi
JT  - Zhonghua yi xue za zhi
JID - 7511141
SB  - IM
MH  - Double-Blind Method
MH  - *Erectile Dysfunction/therapy
MH  - Humans
MH  - Male
MH  - Penile Erection
MH  - Treatment Outcome
MH  - Ultrasonic Therapy
MH  - *Ultrasonic Waves
OTO - NOTNLM
OT  - Erectile Dysfunction
OT  - Low-intensity pulsed ultrasound
OT  - Mechanical force
OT  - Treatment
EDAT- 2020/05/13 06:00
MHDA- 2020/07/22 06:00
CRDT- 2020/05/13 06:00
PHST- 2020/05/13 06:00 [entrez]
PHST- 2020/05/13 06:00 [pubmed]
PHST- 2020/07/22 06:00 [medline]
AID - 10.3760/cma.j.cn112137-20191207-02679 [doi]
PST - ppublish
SO  - Zhonghua Yi Xue Za Zhi. 2020 May 12;100(18):1432-1436. doi: 
      10.3760/cma.j.cn112137-20191207-02679.