PMID- 32394017
OWN - NLM
STAT- MEDLINE
DCOM- 20210317
LR  - 20210317
IS  - 1432-1459 (Electronic)
IS  - 0340-5354 (Linking)
VI  - 267
IP  - 6
DP  - 2020 Jun
TI  - Asymmetry index of Blink Reflex Recovery Cycle differentiates Parkinson's disease 
      from atypical Parkinsonian syndromes.
PG  - 1859-1863
LID - 10.1007/s00415-020-09900-6 [doi]
AB  - BACKGROUND: Differential diagnosis between Parkinson's disease (PD) and atypical 
      Parkinsonian syndromes (APS), such as multiple system atrophy (MSA) and 
      progressive supranuclear palsy (PSP), is often difficult because of overlap of 
      common clinical features. We evaluated R2 Blink Reflex Recovery Cycle (R2BRRC) in 
      drug-naive PD patients and in MSA and PSP patients to differentiate early PD from 
      APS. METHODS: We investigated 43 patients: 15 drug-naive PD patients, 16 MSA 
      patients, and 12 PSP patients. R2BRRC was evaluated bilaterally at interstimulus 
      intervals (ISIs) of 100, 150, 200, 300, 400, 500, and 750 ms. An asymmetry index 
      (AI) of R2BRRC for each ISI was computed. RESULTS: R2BRRC of PD patients showed 
      an increased brainstem excitability for less affected side (LAS) stimulation at 
      ISIs of 100, 150, 200 (p < 0.001), and 300 ms (p = 0.03) compared to more 
      affected side (MAS) stimulation, whereas no differences between LAS and MAS 
      stimulation were found in APS. AI of 0.87 at ISI of 100 ms differentiated PD from 
      MSA with a sensitivity of 86.7% and a specificity of 100%, whereas AI of 0.78 at 
      ISI of 100 ms permitted to discriminate PD from PSP with a sensitivity of 86.7% 
      and a specificity of 91.7%. CONCLUSION: AI of R2BRRC may represent a reliable 
      tool in differentiating PD from APS, especially at the early stage of the 
      disease.
FAU - Sciacca, Giorgia
AU  - Sciacca G
AD  - Department of Medical, Surgical Sciences and Advanced Technologies GF Ingrassia, 
      University of Catania, Via Santa Sofia 78, 95123, Catania, Italy.
FAU - Mostile, Giovanni
AU  - Mostile G
AD  - Department of Medical, Surgical Sciences and Advanced Technologies GF Ingrassia, 
      University of Catania, Via Santa Sofia 78, 95123, Catania, Italy.
FAU - Disilvestro, Ivano
AU  - Disilvestro I
AD  - Department of Medical, Surgical Sciences and Advanced Technologies GF Ingrassia, 
      University of Catania, Via Santa Sofia 78, 95123, Catania, Italy.
FAU - Donzuso, Giulia
AU  - Donzuso G
AD  - Department of Medical, Surgical Sciences and Advanced Technologies GF Ingrassia, 
      University of Catania, Via Santa Sofia 78, 95123, Catania, Italy.
FAU - Manna, Roberta
AU  - Manna R
AD  - Department of Medical, Surgical Sciences and Advanced Technologies GF Ingrassia, 
      University of Catania, Via Santa Sofia 78, 95123, Catania, Italy.
FAU - Portaro, Giacomo
AU  - Portaro G
AD  - Department of Medical, Surgical Sciences and Advanced Technologies GF Ingrassia, 
      University of Catania, Via Santa Sofia 78, 95123, Catania, Italy.
FAU - Rascuna, Cristina
AU  - Rascuna C
AD  - Department of Medical, Surgical Sciences and Advanced Technologies GF Ingrassia, 
      University of Catania, Via Santa Sofia 78, 95123, Catania, Italy.
FAU - Salomone, Salvatore
AU  - Salomone S
AD  - Section of Pharmacology, Department of Biomedical and Biotechnological Sciences, 
      University of Catania, Catania, Italy.
FAU - Drago, Filippo
AU  - Drago F
AD  - Section of Pharmacology, Department of Biomedical and Biotechnological Sciences, 
      University of Catania, Catania, Italy.
FAU - Nicoletti, Alessandra
AU  - Nicoletti A
AD  - Department of Medical, Surgical Sciences and Advanced Technologies GF Ingrassia, 
      University of Catania, Via Santa Sofia 78, 95123, Catania, Italy.
FAU - Zappia, Mario
AU  - Zappia M
AUID- ORCID: 0000-0002-8298-9486
AD  - Department of Medical, Surgical Sciences and Advanced Technologies GF Ingrassia, 
      University of Catania, Via Santa Sofia 78, 95123, Catania, Italy. 
      m.zappia@unict.it.
LA  - eng
PT  - Journal Article
DEP - 20200511
PL  - Germany
TA  - J Neurol
JT  - Journal of neurology
JID - 0423161
SB  - IM
MH  - Aged
MH  - Blinking/*physiology
MH  - Brain Stem/*physiopathology
MH  - Diagnosis, Differential
MH  - Electric Stimulation
MH  - Electromyography
MH  - Facial Muscles/*physiopathology
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Multiple System Atrophy/*diagnosis/physiopathology
MH  - Parkinson Disease/*diagnosis/physiopathology
MH  - Supranuclear Palsy, Progressive/*diagnosis/physiopathology
MH  - Time Factors
OTO - NOTNLM
OT  - Atypical parkinsonism
OT  - Blink Reflex Recovery Cycle
OT  - Multiple system atrophy
OT  - Parkinson's disease
OT  - Progressive supranuclear palsy
EDAT- 2020/05/13 06:00
MHDA- 2021/03/18 06:00
CRDT- 2020/05/13 06:00
PHST- 2020/03/06 00:00 [received]
PHST- 2020/05/07 00:00 [accepted]
PHST- 2020/05/06 00:00 [revised]
PHST- 2020/05/13 06:00 [pubmed]
PHST- 2021/03/18 06:00 [medline]
PHST- 2020/05/13 06:00 [entrez]
AID - 10.1007/s00415-020-09900-6 [pii]
AID - 10.1007/s00415-020-09900-6 [doi]
PST - ppublish
SO  - J Neurol. 2020 Jun;267(6):1859-1863. doi: 10.1007/s00415-020-09900-6. Epub 2020 
      May 11.