PMID- 32394676
OWN - NLM
STAT- MEDLINE
DCOM- 20210712
LR  - 20210712
IS  - 1303-6165 (Electronic)
IS  - 1300-0144 (Print)
IS  - 1300-0144 (Linking)
VI  - 50
IP  - 5
DP  - 2020 Aug 26
TI  - The association between chronic spontaneous urticaria and HLA class I and class 
      II antigen.
PG  - 1231-1235
LID - 10.3906/sag-1907-159 [doi]
AB  - BACKGROUND/AIM: Chronic spontaneous urticaria (CSU) is a chronic disease with an 
      unknown etiology. In human leukocyte antigen (HLA) system, the association of 
      class I and class II antigens with autoimmune diseases has been identified and 
      HLA antigens that have a tendency to or can prevent chronic urticaria have been 
      studied. The aim of this study is to investigate the association between chronic 
      spontaneous urticaria and HLA class I and class II antigens. MATERIALS AND 
      METHODS: A total of 80 subjects, 40 patients with CSU and 40 healthy individuals 
      were enrolled in the study. DNA sample isolation from blood was primarily done by 
      the real-time polymerase chain reaction (RT-PCR) technique for the first time. 
      Using HLA SSP Typing Kit (ROSE Cat. No: 800118) PCR technique, HLA-A, B, C, DRB 
      and DQB alleles from DNA samples were analyzed. RESULTS: The mean age was 36.80 +/- 
      9.48 years and the duration of the disease was 4.26 +/- 5.18 years. Among the HLA 
      class I and class II antigens, HLA-A was detected significantly more often in the 
      control group (P = 0.039). HLA-DRB1 was more often detected in the CSU group but 
      no statistical difference (P > 0.05). CONCLUSION: It can be considered that 
      HLA-DRB1 may have a tendency to CSU, while HLA-A might prevent the disease.
CI  - This work is licensed under a Creative Commons Attribution 4.0 International 
      License.
FAU - Dogan, Neslihan
AU  - Dogan N
AUID- ORCID: 0000-0002-6441-7847
AD  - Department of Internal Medicine, Faculty of Medicine, Aydin Adnan Menderes 
      University, Aydin, Turkey
FAU - Cildag, Songul
AU  - Cildag S
AUID- ORCID: 0000-0001-9617-0925
AD  - Department of Immunology and Allergy, Faculty of Medicine, Aydin Adnan Menderes 
      University, Aydin, Turkey
FAU - Yenisey, Cigdem
AU  - Yenisey C
AUID- ORCID: 0000-0001-7693-641X
AD  - Department of Biochemistry, Faculty of Medicine, Aydin Adnan Menderes University, 
      Aydin, Turkey
FAU - Senturk, Taskin
AU  - Senturk T
AUID- ORCID: 0000-0002-1560-6764
AD  - Department of Biochemistry, Faculty of Medicine, Aydin Adnan Menderes University, 
      Aydin, Turkey
LA  - eng
PT  - Journal Article
DEP - 20200826
PL  - Turkey
TA  - Turk J Med Sci
JT  - Turkish journal of medical sciences
JID - 9441758
RN  - 0 (Histocompatibility Antigens Class I)
RN  - 0 (Histocompatibility Antigens Class II)
SB  - IM
MH  - Adult
MH  - *Chronic Urticaria/epidemiology/genetics
MH  - Cross-Sectional Studies
MH  - Female
MH  - Histocompatibility Antigens Class I/*genetics
MH  - Histocompatibility Antigens Class II/*genetics
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Young Adult
PMC - PMC7491287
OTO - NOTNLM
OT  - Chronic spontaneous urticaria
OT  - HLA antigens
OT  - genetic
COIS- All authors report no conflict of interest in this study.
EDAT- 2020/05/13 06:00
MHDA- 2021/07/13 06:00
PMCR- 2020/08/26
CRDT- 2020/05/13 06:00
PHST- 2019/07/25 00:00 [received]
PHST- 2020/05/05 00:00 [accepted]
PHST- 2020/05/13 06:00 [entrez]
PHST- 2020/05/13 06:00 [pubmed]
PHST- 2021/07/13 06:00 [medline]
PHST- 2020/08/26 00:00 [pmc-release]
AID - 10.3906/sag-1907-159 [doi]
PST - epublish
SO  - Turk J Med Sci. 2020 Aug 26;50(5):1231-1235. doi: 10.3906/sag-1907-159.