PMID- 32395387
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220414
IS  - 2093-2278 (Print)
IS  - 2093-2286 (Electronic)
IS  - 2093-2278 (Linking)
VI  - 50
IP  - 2
DP  - 2020 Apr
TI  - Efficacy of non-surgical treatment accompanied by professional toothbrushing in 
      the treatment of chronic periodontitis in patients with type 2 diabetes mellitus: 
      a randomized controlled clinical trial.
PG  - 83-96
LID - 10.5051/jpis.2020.50.2.83 [doi]
AB  - PURPOSE: The present study aimed to evaluate the clinical benefit of additional 
      toothbrushing accompanying non-surgical periodontal treatment on oral and general 
      health in patients with type 2 diabetes mellitus (T2DM). METHODS: We conducted a 
      doubled-blind randomized controlled trial in 60 T2DM patients between June 2013 
      and June 2014. The patients were randomly assigned to the scaling and root 
      planing (SRP) group; the scaling and root planing with additional toothbrushing 
      (SRPAT) group, in which additional toothbrushing was performed by toothpick 
      methods; or the control group. Microbiological and oral examinations were 
      performed for up to 12 weeks following treatment. Non-surgical treatment was 
      conducted in the experimental groups. The SRP group received scaling and root 
      planing and the SRPAT group received additional toothbrushing with the Watanabe 
      method once a week from the first visit through the fifth visit. The primary 
      outcomes were changes in haemoglobin A1c (or glycated haemoglobin; HbA1c) levels, 
      serum endotoxin levels, and interleukin-1 beta levels. Periodontal health status 
      was measured by periodontal pocket depth, the calculus index, and bleeding on 
      probing (BOP). RESULTS: Both the SRP and SRPAT groups showed improvements in 
      periodontal health and HbA1c, but the SRPAT group showed significantly less BOP 
      than the SRP group. Furthermore, only the SRPAT group showed a statistically 
      significant decrease in serum endotoxin levels. CONCLUSIONS: Non-surgical 
      periodontal treatment was effective in improving HbA1c and serum endotoxin levels 
      in T2DM patients. Furthermore, non-surgical treatment with additional tooth 
      brushing had a more favourable effect on gingival bleeding management.Trial 
      RegistrationClinical Research Information Service Identifier: KCT000416.
CI  - Copyright (c) 2020. Korean Academy of Periodontology.
FAU - Lee, Jae Young
AU  - Lee JY
AUID- ORCID: 0000-0003-2394-5894
AD  - Department of Preventive and Public Health Dentistry, Seoul National University 
      School of Dentistry, Seoul, Korea.
AD  - Dental Research Institute, Seoul National University School of Dentistry, Seoul, 
      Korea.
FAU - Choi, Yoon Young
AU  - Choi YY
AUID- ORCID: 0000-0001-5141-2062
AD  - Department of Preventive and Public Health Dentistry, Seoul National University 
      School of Dentistry, Seoul, Korea.
FAU - Choi, Youngnim
AU  - Choi Y
AUID- ORCID: 0000-0002-6496-5560
AD  - Department of Immunology and Molecular Microbiology, Seoul National University 
      School of Dentistry, Seoul, Korea.
FAU - Jin, Bo Hyoung
AU  - Jin BH
AUID- ORCID: 0000-0003-3526-6805
AD  - Department of Preventive and Public Health Dentistry, Seoul National University 
      School of Dentistry, Seoul, Korea.
LA  - eng
PT  - Journal Article
DEP - 20200423
PL  - Korea (South)
TA  - J Periodontal Implant Sci
JT  - Journal of periodontal & implant science
JID - 101526931
PMC - PMC7192821
OTO - NOTNLM
OT  - Diabetes mellitus
OT  - Glycated hemoglobin A
OT  - Interleukins
OT  - Periodontitis
OT  - Toothbrushing
COIS- Conflict of Interest: No potential conflict of interest relevant to this article 
      was reported.
EDAT- 2020/05/13 06:00
MHDA- 2020/05/13 06:01
PMCR- 2020/04/01
CRDT- 2020/05/13 06:00
PHST- 2020/03/04 00:00 [received]
PHST- 2020/04/11 00:00 [revised]
PHST- 2020/04/20 00:00 [accepted]
PHST- 2020/05/13 06:00 [entrez]
PHST- 2020/05/13 06:00 [pubmed]
PHST- 2020/05/13 06:01 [medline]
PHST- 2020/04/01 00:00 [pmc-release]
AID - 10.5051/jpis.2020.50.2.83 [doi]
PST - epublish
SO  - J Periodontal Implant Sci. 2020 Apr 23;50(2):83-96. doi: 
      10.5051/jpis.2020.50.2.83. eCollection 2020 Apr.