PMID- 32395440 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20200928 IS - 2287-3732 (Print) IS - 2287-3740 (Electronic) IS - 2287-3732 (Linking) VI - 9 IP - 2 DP - 2020 Apr TI - Effects of Chromium Picolinate Supplementation on Cardiometabolic Biomarkers in Patients with Type 2 Diabetes Mellitus: a Randomized Clinical Trial. PG - 97-106 LID - 10.7762/cnr.2020.9.2.97 [doi] AB - Type 2 diabetes mellitus (T2DM) is a serious public health problem accompanies with several complications. This study was conducted to evaluate the effects of chromium picolinate (CrPic) supplementation on the glycemic status and lipid profile in patients with T2DM. The patients with T2DM (n = 52) were randomly allocated into 2 groups. One group received 400 microg CrPic per day and the other group took placebo; the intervention duration was 8 weeks. Anthropometric indices and metabolic factors were measured at the beginning, and at end of the study. The patients were recommended not to change their normal diet, life style and medication. No significant changes were observed for weight, body mass index, and fasting blood glucose (FBG) in both groups; while intra-groups changes in homeostatic model assessment for insulin resistance (HOMA-IR) value was significant (p < 0.05). Results of analysis of covariance showed that there were significance differences between groups in total cholesterol, low density lipoprotein cholesterol and HOMA-IR at the end of the intervention adjusting for baseline levels (p = 0.035, 0.030 and < 0.001, respectively). In this study, oral supplementation with 400 microg CrPic for eight weeks did not alter FBG concentration as well as anthropometric parameters in individuals with T2DM. However, the modest beneficial effects of chromium supplementation on insulin resistance as indicated by HOMA-IR and lipid profile were found. CI - Copyright (c) 2020. The Korean Society of Clinical Nutrition. FAU - Talab, Aria Tavakoli AU - Talab AT AUID- ORCID: 0000-0001-7542-9424 AD - Be'sat Hospital, Hamadan University of Medical Sciences, Hamadan 6517838678, Iran. FAU - Abdollahzad, Hadi AU - Abdollahzad H AUID- ORCID: 0000-0003-2367-9573 AD - Department of Nutrition, Research Center for Environmental Determinants of Health, Health Institute, Kermanshah University of Medical Sciences, Kermanshah 6719851351, Iran. FAU - Nachvak, Seyyed Mustafa AU - Nachvak SM AUID- ORCID: 0000-0002-7265-3495 AD - Department of Nutrition, Research Center for Environmental Determinants of Health, Health Institute, Kermanshah University of Medical Sciences, Kermanshah 6719851351, Iran. FAU - Pasdar, Yahya AU - Pasdar Y AUID- ORCID: 0000-0001-8682-5721 AD - Department of Nutrition, Research Center for Environmental Determinants of Health, Health Institute, Kermanshah University of Medical Sciences, Kermanshah 6719851351, Iran. FAU - Eghtesadi, Shahryar AU - Eghtesadi S AUID- ORCID: 0000-0002-9112-6391 AD - Islamic Azad University; Tehran Medical Branch and Science & Research Branch, Tehran 1477983855, Iran. FAU - Izadi, Azimeh AU - Izadi A AUID- ORCID: 0000-0002-1038-9369 AD - Students' Research Committee, Faculty of Nutrition, Tabriz University of Medical Sciences, Tabriz 5166614711, Iran. FAU - Aghdashi, Mir Amir AU - Aghdashi MA AUID- ORCID: 0000-0001-8826-4585 AD - Department of Internal Medicine, Faculty of Medicine, Urmia University of Medical Sciences, Urmia 5714783734, Iran. FAU - Mohammad Hossseini Azar, Mohammad Reza AU - Mohammad Hossseini Azar MR AUID- ORCID: 0000-0002-9720-8267 AD - Department of Internal Medicine, Faculty of Medicine, Urmia University of Medical Sciences, Urmia 5714783734, Iran. FAU - Moradi, Sedighe AU - Moradi S AUID- ORCID: 0000-0002-1840-6186 AD - Endocrine Research Center, Institute of Endocrinology and Metabolism, Iran University of Medical Sciences, Tehran 1593716615, Iran. FAU - Mehaki, Behzad AU - Mehaki B AUID- ORCID: 0000-0001-7062-6971 AD - Department of Biostatistics, Research Center for Environmental Determinants of Health, Health Institute, Kermanshah University of Medical Sciences, Kermanshah 6715847141, Iran. FAU - Moradi, Shima AU - Moradi S AUID- ORCID: 0000-0002-6507-7928 AD - Department of Nutrition, Research Center for Environmental Determinants of Health, Health Institute, Kermanshah University of Medical Sciences, Kermanshah 6719851351, Iran. LA - eng PT - Journal Article DEP - 20200424 PL - Korea (South) TA - Clin Nutr Res JT - Clinical nutrition research JID - 101592483 PMC - PMC7192664 OTO - NOTNLM OT - Blood glucose OT - Chromium OT - Dyslipidemia OT - Type 2 diabetes mellitus COIS- Conflict of Interest: The authors declare that they have no competing interests. EDAT- 2020/05/13 06:00 MHDA- 2020/05/13 06:01 PMCR- 2020/04/01 CRDT- 2020/05/13 06:00 PHST- 2020/02/05 00:00 [received] PHST- 2020/04/17 00:00 [revised] PHST- 2020/04/19 00:00 [accepted] PHST- 2020/05/13 06:00 [entrez] PHST- 2020/05/13 06:00 [pubmed] PHST- 2020/05/13 06:01 [medline] PHST- 2020/04/01 00:00 [pmc-release] AID - 10.7762/cnr.2020.9.2.97 [doi] PST - epublish SO - Clin Nutr Res. 2020 Apr 24;9(2):97-106. doi: 10.7762/cnr.2020.9.2.97. eCollection 2020 Apr.