PMID- 32395767
OWN - NLM
STAT- MEDLINE
DCOM- 20210330
LR  - 20210330
IS  - 1573-4935 (Electronic)
IS  - 0144-8463 (Print)
IS  - 0144-8463 (Linking)
VI  - 40
IP  - 6
DP  - 2020 Jun 26
TI  - Protective effect of Asarum sieboldii essential oil on ovalbumin induced allergic 
      rhinitis in rat.
LID - 10.1042/BSR20191370 [doi]
LID - BSR20191370
AB  - BACKGROUND: The study was aimed to investigate the protective effect of Asarum 
      sieboldii Miq. essential oil (AEO) on ovalbumin (OVA)-induced allergic rhinitis 
      (AR) in rats. METHODS AND RESULTS: Sixty Sprague-Dawley male rats were randomly 
      divided into six groups (n=10): control, model, cetirizine (Cet, 4.65 g/kg), and 
      AEO (0.5, 1.5, 3 g/kg) groups. All animals except the control group received 
      repeated intranasal instillation with 20 mul of 20% OVA in Al(OH)3 saline solvent 
      for 15 days. The control group was intranasally instilled with 5 mg/ml of Al(OH)3 
      instead of the same procedure. In the 15 days, Cet and AEO were orally 
      administrated for 28 days. At the end of the drug administration, 20 mul of 5% OVA 
      was given to animals to stimulate allergic reaction, then the rat behavioral 
      detection, assessment of the patho-morphological changes in nasal mucosa, and the 
      serum biomarkers were determined. The result showed that AEO could significantly 
      reduce the amount of nasal secretions, sneezing, and the degree of nasal 
      scratching in AR rats with EC50 = 1.5 and 2.8 g/kg, respectively. The degree of 
      nasal mucosal inflammation in AEO group improved, the levels of immunoglobulin E 
      (IgE), histamine, IL-4, IL-5, IL-17 were decreased, and the level of IFN-gamma was 
      increased obviously with EC50 = 2 g/kg. CONCLUSION: The study suggested that the 
      possible mechanism might be related with the inhibition of histamine release and 
      regulation of the cytokine levels, which plays an important role in the treatment 
      of AR.
CI  - (c) 2020 The Author(s).
FAU - Zhang, Zhicheng
AU  - Zhang Z
AD  - Department of Otorhinolaryngology, The First Affiliated Hospital of Henan 
      University of Chinese Medicine, Zhengzhou 450000, People's Republic of China.
FAU - Kang, Haoran
AU  - Kang H
AD  - Department of Otorhinolaryngology, The First Affiliated Hospital of Henan 
      University of Chinese Medicine, Zhengzhou 450000, People's Republic of China.
LA  - eng
PT  - Journal Article
PL  - England
TA  - Biosci Rep
JT  - Bioscience reports
JID - 8102797
RN  - 0 (Anti-Allergic Agents)
RN  - 0 (Cytokines)
RN  - 0 (Drugs, Chinese Herbal)
RN  - 0 (Oils, Volatile)
RN  - 0 (Plant Oils)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - 8016-69-1 (asarum oil)
RN  - 820484N8I3 (Histamine)
RN  - 9006-59-1 (Ovalbumin)
SB  - IM
ECI - Biosci Rep. 2020 Jun 26;40(6):. PMID: 32568382
MH  - Animals
MH  - Anti-Allergic Agents/isolation & purification/*pharmacology
MH  - *Asarum/chemistry
MH  - Behavior, Animal/drug effects
MH  - Cytokines/blood
MH  - Disease Models, Animal
MH  - Drugs, Chinese Herbal/isolation & purification/*pharmacology
MH  - Histamine/blood
MH  - Immunoglobulin E/blood
MH  - Male
MH  - Nasal Mucosa/*drug effects/immunology/metabolism
MH  - Oils, Volatile/isolation & purification/*pharmacology
MH  - Ovalbumin
MH  - Plant Oils/isolation & purification/*pharmacology
MH  - Rats, Sprague-Dawley
MH  - Rhinitis, Allergic/blood/chemically induced/immunology/*prevention & control
PMC - PMC7268255
OTO - NOTNLM
OT  - Nasal mucosa
OT  - cytokines
OT  - histamine
OT  - nasal scratching
OT  - sneezing
COIS- The authors declare that there are no competing interests associated with the 
      manuscript.
EDAT- 2020/05/13 06:00
MHDA- 2021/03/31 06:00
PMCR- 2020/06/02
CRDT- 2020/05/13 06:00
PHST- 2019/05/07 00:00 [received]
PHST- 2020/04/24 00:00 [revised]
PHST- 2020/05/07 00:00 [accepted]
PHST- 2020/05/13 06:00 [pubmed]
PHST- 2021/03/31 06:00 [medline]
PHST- 2020/05/13 06:00 [entrez]
PHST- 2020/06/02 00:00 [pmc-release]
AID - 224117 [pii]
AID - BSR20191370 [pii]
AID - 10.1042/BSR20191370 [doi]
PST - ppublish
SO  - Biosci Rep. 2020 Jun 26;40(6):BSR20191370. doi: 10.1042/BSR20191370.