PMID- 32395809 OWN - NLM STAT- MEDLINE DCOM- 20201001 LR - 20201001 IS - 2724-7031 (Electronic) IS - 0041-4131 (Linking) VI - 98 IP - 2 DP - 2020 Feb TI - Mammary analogue secretory carcinoma: A case report. PG - 168-171 AB - BACKGROUND: Mammary analogue secretory carcinoma is a rare new entity of low-grade malignant tumor of salivary glands. It shared the same histologic features and the chromosomal translocation t(12;15)(p13;q25) as secretory carcinoma of the breast. AIM: To highlight the diagnosis approaches and the attitude of management in a case of MASC which is the first case reported in Tunisia. Reported case: A case of MASC of the lower left jugal mucosa was reviewed for its microscopic and immunohistochemical features. Fluorescence in situ hybridization (FISH) for the ETV6-NTRK3 translocation was performed. Surgery was the only treatment required in this case. No signs of local or regional recurrence during the one-year follow-up were noticed. COMMENTARIES: Secretory carcinoma was confused with other salivary gland tumors especially acinic cell carcinoma due to their morphological similarities, making diagnosis dilemma. Fluorescence in-situ hybridization (FISH) is the one definitive finding to confirm the diagnosis of MASC and to differentiate it from the other types of salivary gland tumor. At the present time, no specific therapy is available for patients with MASC. FAU - Hedhli, Fatma AU - Hedhli F FAU - Ouertani, Hend AU - Ouertani H FAU - Gargouri, Faten AU - Gargouri F FAU - Naija, Sonia AU - Naija S FAU - Casiraghi, Odile AU - Casiraghi O FAU - Valent, Alexander AU - Valent A FAU - Khatteche, Bassem AU - Khatteche B LA - eng PT - Case Reports PT - Journal Article PL - Tunisia TA - Tunis Med JT - La Tunisie medicale JID - 0413766 RN - 0 (ANO1 protein, human) RN - 0 (Anoctamin-1) RN - 0 (ETV6-NTRK3 fusion protein, human) RN - 0 (Mammaglobin A) RN - 0 (Neoplasm Proteins) RN - 0 (Oncogene Proteins, Fusion) RN - 0 (S100 Proteins) SB - IM MH - Anoctamin-1/analysis/metabolism MH - Cheek/pathology MH - Cytogenetic Analysis MH - Diagnosis, Differential MH - Female MH - Humans MH - Immunohistochemistry MH - In Situ Hybridization, Fluorescence MH - Mammaglobin A/analysis/metabolism MH - Mammary Analogue Secretory Carcinoma/*diagnosis/genetics/surgery MH - Mouth Mucosa/metabolism/pathology MH - Neoplasm Proteins/analysis/metabolism MH - Oncogene Proteins, Fusion/analysis/genetics MH - S100 Proteins/analysis/metabolism MH - Tunisia EDAT- 2020/05/13 06:00 MHDA- 2020/10/02 06:00 CRDT- 2020/05/13 06:00 PHST- 2020/05/13 06:00 [entrez] PHST- 2020/05/13 06:00 [pubmed] PHST- 2020/10/02 06:00 [medline] AID - /article-medicale-tunisie.php?article=3692 [pii] PST - ppublish SO - Tunis Med. 2020 Feb;98(2):168-171.