PMID- 32396562
OWN - NLM
STAT- MEDLINE
DCOM- 20200805
LR  - 20200805
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 15
IP  - 5
DP  - 2020
TI  - Possible risk factors for poor asthma control assessed in a cross-sectional 
      population-based study from Telemark, Norway.
PG  - e0232621
LID - 10.1371/journal.pone.0232621 [doi]
LID - e0232621
AB  - This cross-sectional study of the general population of Telemark County, Norway, 
      aimed to identify risk factors associated with poor asthma control as defined by 
      the Asthma Control Test (ACT), and to determine the proportions of patients with 
      poorly controlled asthma who had undergone spirometry, used asthma medication, or 
      been examined by a pulmonary physician. In 2014-2015, the study recruited 326 
      subjects aged 16-50 years who had self-reported physician-diagnosed asthma and 
      presence of respiratory symptoms during the previous 12 months. The clinical 
      outcome measures were body mass index (BMI), forced vital capacity (FVC) and 
      forced expiratory volume in one second (FEV1), fractional exhaled nitric oxide 
      (FeNO), immunoglobulin E (IgE) in serum and serum C-reactive protein (CRP). An 
      ACT score </= 19 was defined as poorly controlled asthma. Overall, 113 subjects 
      (35%) reported poor asthma control. The odds ratios (ORs) and 95% confidence 
      intervals (CIs) for factors associated with poorly controlled asthma were: 
      self-reported occupational exposure to vapor, gas, dust, or fumes during the 
      previous 12 months (OR 2.0; 95% CI 1.1-3.6), body mass index >/= 30 kg/m2 (OR 2.2; 
      95% CI 1.2-4.1), female sex (OR 2.6; 95% CI 1.5-4.7), current smoking (OR 2.8; 
      95% CI 1.5-5.3), and past smoking (OR 2.3; 95% CI 1.3-4.0). Poor asthma control 
      was also associated with reduced FEV1 after bronchodilation (beta -3.6; 95% CI -7.0 
      to -0.2). Moreover, 13% of the participants with poor asthma control reported no 
      use of asthma medication, 51% had not been assessed by a pulmonary physician, and 
      20% had never undergone spirometry. Because these data are cross-sectional, 
      further studies assessing possible risk factors in general and objectively 
      measured occupational exposure in particular are needed. However, our results 
      suggest that there is room for improvement with regards to use of spirometry and 
      pulmonary physician referrals when a patient's asthma is inadequately controlled.
FAU - Abrahamsen, Regine
AU  - Abrahamsen R
AD  - Department of Occupational and Environmental Medicine, Telemark Hospital, Skien, 
      Norway.
FAU - Gundersen, Golin Finckenhagen
AU  - Gundersen GF
AD  - Department of Occupational and Environmental Medicine, Telemark Hospital, Skien, 
      Norway.
FAU - Svendsen, Martin Veel
AU  - Svendsen MV
AD  - Department of Occupational and Environmental Medicine, Telemark Hospital, Skien, 
      Norway.
FAU - Klepaker, Geir
AU  - Klepaker G
AD  - Department of Occupational and Environmental Medicine, Telemark Hospital, Skien, 
      Norway.
AD  - Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, 
      Norway.
FAU - Kongerud, Johny
AU  - Kongerud J
AD  - Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, 
      Norway.
AD  - Department of Respiratory Medicine, Oslo University Hospital, Oslo, Norway.
FAU - Fell, Anne Kristin Moller
AU  - Fell AKM
AUID- ORCID: 0000-0003-1160-8380
AD  - Department of Occupational and Environmental Medicine, Telemark Hospital, Skien, 
      Norway.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20200512
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Asthma/*epidemiology/*therapy
MH  - Cross-Sectional Studies
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Norway/epidemiology
MH  - Occupational Exposure/adverse effects
MH  - Referral and Consultation/statistics & numerical data
MH  - Risk Factors
MH  - Spirometry/statistics & numerical data
MH  - Young Adult
PMC - PMC7217450
COIS- The authors have declared that no competing interests exist.
EDAT- 2020/05/13 06:00
MHDA- 2020/08/06 06:00
PMCR- 2020/05/12
CRDT- 2020/05/13 06:00
PHST- 2019/12/11 00:00 [received]
PHST- 2020/04/17 00:00 [accepted]
PHST- 2020/05/13 06:00 [entrez]
PHST- 2020/05/13 06:00 [pubmed]
PHST- 2020/08/06 06:00 [medline]
PHST- 2020/05/12 00:00 [pmc-release]
AID - PONE-D-19-34283 [pii]
AID - 10.1371/journal.pone.0232621 [doi]
PST - epublish
SO  - PLoS One. 2020 May 12;15(5):e0232621. doi: 10.1371/journal.pone.0232621. 
      eCollection 2020.