PMID- 32397180
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240329
IS  - 2310-2861 (Electronic)
IS  - 2310-2861 (Linking)
VI  - 6
IP  - 2
DP  - 2020 May 8
TI  - Stimuli-Responsive Hydrogels for Local Post-Surgical Drug Delivery.
LID - 10.3390/gels6020014 [doi]
LID - 14
AB  - Currently, surgical operations, followed by systemic drug delivery, are the 
      prevailing treatment modality for most diseases, including cancers and 
      trauma-based injuries. Although effective to some extent, the side effects of 
      surgery include inflammation, pain, a lower rate of tissue regeneration, disease 
      recurrence, and the non-specific toxicity of chemotherapies, which remain 
      significant clinical challenges. The localized delivery of therapeutics has 
      recently emerged as an alternative to systemic therapy, which not only allows the 
      delivery of higher doses of therapeutic agents to the surgical site, but also 
      enables overcoming post-surgical complications, such as infections, 
      inflammations, and pain. Due to the limitations of the current drug delivery 
      systems, and an increasing clinical need for disease-specific drug release 
      systems, hydrogels have attracted considerable interest, due to their unique 
      properties, including a high capacity for drug loading, as well as a sustained 
      release profile. Hydrogels can be used as local drug performance carriers as a 
      means for diminishing the side effects of current systemic drug delivery methods 
      and are suitable for the majority of surgery-based injuries. This work summarizes 
      recent advances in hydrogel-based drug delivery systems (DDSs), including 
      formulations such as implantable, injectable, and sprayable hydrogels, with a 
      particular emphasis on stimuli-responsive materials. Moreover, clinical 
      applications and future opportunities for this type of post-surgery treatment are 
      also highlighted.
FAU - Askari, Esfandyar
AU  - Askari E
AD  - Biomaterials and Tissue Engineering Department, Breast Cancer Research Center, 
      Motamed Cancer Institute, ACECR, Tehran P.O. Box 1517964311, Iran.
FAU - Seyfoori, Amir
AU  - Seyfoori A
AD  - Laboratory for Innovations in Micro Engineering (LiME), Department of Mechanical 
      Engineering, University of Victoria, Victoria, BC V8P 5C2, Canada.
FAU - Amereh, Meitham
AU  - Amereh M
AD  - Laboratory for Innovations in Micro Engineering (LiME), Department of Mechanical 
      Engineering, University of Victoria, Victoria, BC V8P 5C2, Canada.
FAU - Gharaie, Sadaf Samimi
AU  - Gharaie SS
AD  - Laboratory for Innovations in Micro Engineering (LiME), Department of Mechanical 
      Engineering, University of Victoria, Victoria, BC V8P 5C2, Canada.
FAU - Ghazali, Hanieh Sadat
AU  - Ghazali HS
AD  - Nanotechnology Department, School of Advanced Technologies, Iran University of 
      Science and Technology, Tehran P.O. Box 16846-13114, Iran.
FAU - Ghazali, Zahra Sadat
AU  - Ghazali ZS
AD  - Biomedical Engineering Department, Amirkabir University of Technology (AUT), 
      Tehran P.O. Box 158754413, Iran.
FAU - Khunjush, Bardia
AU  - Khunjush B
AD  - Laboratory for Innovations in Micro Engineering (LiME), Department of Mechanical 
      Engineering, University of Victoria, Victoria, BC V8P 5C2, Canada.
FAU - Akbari, Mohsen
AU  - Akbari M
AUID- ORCID: 0000-0003-2902-6557
AD  - Laboratory for Innovations in Micro Engineering (LiME), Department of Mechanical 
      Engineering, University of Victoria, Victoria, BC V8P 5C2, Canada.
AD  - Center for Biomedical Research, University of Victoria, Victoria, BC V8P 5C2, 
      Canada.
AD  - Center for Advanced Materials and Related Technologies, University of Victoria, 
      Victoria, BC V8P 5C2, Canada.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20200508
PL  - Switzerland
TA  - Gels
JT  - Gels (Basel, Switzerland)
JID - 101696925
PMC - PMC7345431
OTO - NOTNLM
OT  - drug delivery systems
OT  - hydrogel
OT  - implantable
OT  - injectable
OT  - sprayable
COIS- The authors declare no conflict of interest.
EDAT- 2020/05/14 06:00
MHDA- 2020/05/14 06:01
PMCR- 2020/05/08
CRDT- 2020/05/14 06:00
PHST- 2020/03/10 00:00 [received]
PHST- 2020/04/28 00:00 [revised]
PHST- 2020/04/30 00:00 [accepted]
PHST- 2020/05/14 06:00 [entrez]
PHST- 2020/05/14 06:00 [pubmed]
PHST- 2020/05/14 06:01 [medline]
PHST- 2020/05/08 00:00 [pmc-release]
AID - gels6020014 [pii]
AID - gels-06-00014 [pii]
AID - 10.3390/gels6020014 [doi]
PST - epublish
SO  - Gels. 2020 May 8;6(2):14. doi: 10.3390/gels6020014.