PMID- 32398083
OWN - NLM
STAT- MEDLINE
DCOM- 20200911
LR  - 20200911
IS  - 1477-7525 (Electronic)
IS  - 1477-7525 (Linking)
VI  - 18
IP  - 1
DP  - 2020 May 12
TI  - How is the minimal clinically important difference established in health-related 
      quality of life instruments? Review of anchors and methods.
PG  - 136
LID - 10.1186/s12955-020-01344-w [doi]
LID - 136
AB  - BACKGROUND: The aim of this systematic review is to describe the different types 
      of anchors and statistical methods used in estimating the Minimal Clinically 
      Important Difference (MCID) for Health-Related Quality of Life (HRQoL) 
      instruments. METHODS: PubMed and Google scholar were searched for English and 
      French language studies published from 2010 to 2018 using selected keywords. We 
      included original articles (reviews, meta-analysis, commentaries and research 
      letters were not considered) that described anchors and statistical methods used 
      to estimate the MCID in HRQoL instruments. RESULTS: Forty-seven papers satisfied 
      the inclusion criteria. The MCID was estimated for 6 generic and 18 
      disease-specific instruments. Most studies in our review used anchor-based 
      methods (n = 41), either alone or in combination with distribution-based methods. 
      The most common applied anchors were non-clinical, from the viewpoint of 
      patients. Different statistical methods for anchor-based methods were applied and 
      the Change Difference (CD) was the most used one. Most distributional methods 
      included 0.2 standard deviations (SD), 0.3 SD, 0.5 SD and 1 standard error of 
      measurement (SEM). MCID values were very variable depending on methods applied, 
      and also on clinical context of the study. CONCLUSION: Multiple anchors and 
      methods were applied in the included studies, which lead to different estimations 
      of MCID. Using several methods enables to assess the robustness of the results. 
      This corresponds to a sensitivity analysis of the methods. Close collaboration 
      between statisticians and clinicians is recommended to integrate an agreement 
      regarding the appropriate method to determine MCID for a specific context.
FAU - Mouelhi, Yosra
AU  - Mouelhi Y
AD  - Laboratoire de Sante Publique, Faculte de Medecine, Universite Aix-Marseille, 
      3279, Marseille, EA, France.
FAU - Jouve, Elisabeth
AU  - Jouve E
AD  - Service d'Evaluation Medicale, Assistance Publique - Hopitaux de Marseille, 
      Marseille, France.
FAU - Castelli, Christel
AU  - Castelli C
AD  - Service Biostatistique Epidemiologie Sante Publique Innovation et Methodologie 
      (BESPIM), CHU Nimes, Nimes, France.
AD  - UPRES EA 2415 Aide a la decision medicale personnalisee, Faculte de Medecine, 
      Universite de Montpellier, Montpellier, France.
FAU - Gentile, Stephanie
AU  - Gentile S
AD  - Laboratoire de Sante Publique, Faculte de Medecine, Universite Aix-Marseille, 
      3279, Marseille, EA, France. StephanieMarie.GENTILE@ap-hm.fr.
AD  - Service d'Evaluation Medicale, Assistance Publique - Hopitaux de Marseille, 
      Marseille, France. StephanieMarie.GENTILE@ap-hm.fr.
LA  - eng
PT  - Journal Article
PT  - Systematic Review
DEP - 20200512
PL  - England
TA  - Health Qual Life Outcomes
JT  - Health and quality of life outcomes
JID - 101153626
SB  - IM
MH  - Adult
MH  - Aged
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - *Minimal Clinically Important Difference
MH  - Psychometrics/instrumentation
MH  - *Quality of Life
PMC - PMC7218583
OTO - NOTNLM
OT  - Anchors-based methods
OT  - Distribution-based methods
OT  - Health-related-quality of life
OT  - Minimal clinically important difference
COIS- The authors declare they have no competing interest.
EDAT- 2020/05/14 06:00
MHDA- 2020/09/12 06:00
PMCR- 2020/05/12
CRDT- 2020/05/14 06:00
PHST- 2019/03/27 00:00 [received]
PHST- 2020/04/01 00:00 [accepted]
PHST- 2020/05/14 06:00 [entrez]
PHST- 2020/05/14 06:00 [pubmed]
PHST- 2020/09/12 06:00 [medline]
PHST- 2020/05/12 00:00 [pmc-release]
AID - 10.1186/s12955-020-01344-w [pii]
AID - 1344 [pii]
AID - 10.1186/s12955-020-01344-w [doi]
PST - epublish
SO  - Health Qual Life Outcomes. 2020 May 12;18(1):136. doi: 
      10.1186/s12955-020-01344-w.