PMID- 32398715
OWN - NLM
STAT- MEDLINE
DCOM- 20201130
LR  - 20210512
IS  - 2045-2322 (Electronic)
IS  - 2045-2322 (Linking)
VI  - 10
IP  - 1
DP  - 2020 May 12
TI  - Interaction Between Apolipoprotein M Gene Single-Nucleotide Polymorphisms and 
      Obesity and its Effect on Type 2 Diabetes Mellitus Susceptibility.
PG  - 7859
LID - 10.1038/s41598-020-64467-6 [doi]
LID - 7859
AB  - This study investigated the correlation of four single nucleotide polymorphisms 
      (SNPs) in Apolipoprotein M (ApoM) with the risk of type 2 diabetes mellitus 
      (T2DM) and effects of the interactions of this gene and obesity. The effects of 
      SNP and obesity interaction on T2DM was examined by generalized multifactor 
      dimensionality reduction (GMDR) combined with the logistic regression model. T2DM 
      patient-control haplotype was analyzed in silico using the haplotype analysis 
      algorithm SHEsis. The rs805296-C allele or 724-del allele indicted high risk of 
      T2DM. The incidence of T2DM in individuals with rs805296-C allele polymorphism 
      (TC + CC) was higher than those without (TT), adjusted OR (95%CI) = 1.29 
      (1.10-1.66) (p < 0.001). Moreover, the individuals with 724-delallele have a 
      higher risk of T2DM compared to those with 724-ins variants, adjusted OR 
      (95%CI) = 1.66 (1.40-2.06), p < 0.001. GMDR analysis suggested that the 
      interaction model composed of the two factors, rs805296 and obesity, was the best 
      model with statistical significance (P value from sign test [P(sign)]=0.0107). 
      The T2DM risk in obese individuals having TC or CC genotype was higher than 
      non-obese individuals with TT genotype (OR = 2.38, 95% CI = 1.58-3.53). Haplotype 
      analysis suggests that rs805297-C and rs9404941-C alleles haplotype indicate high 
      risk of T2DM, OR (95%CI) = 1.62 (1.29-2.16), p < 0.001. Our results suggested 
      that rs805296 and 724-del minor allele of ApoM gene, interaction of rs805296 and 
      obesity, rs805297-C and rs9404941-C alleles haplotype were indicators of high 
      T2DM risk.
FAU - Liu, Dan
AU  - Liu D
AD  - Department of Endocrinology, The third people's Hospital of Hainan Province, 
      Sanya, China. liudandde16@163.com.
FAU - Pan, Jian-Min
AU  - Pan JM
AD  - Department of general surgery, The third people's Hospital of Hainan Province, 
      Sanya, China.
FAU - Pei, Xiang
AU  - Pei X
AD  - Department of Endocrinology, The third people's Hospital of Hainan Province, 
      Sanya, China.
FAU - Li, Jun-Sen
AU  - Li JS
AD  - Department of Endocrinology, The third people's Hospital of Hainan Province, 
      Sanya, China.
LA  - eng
PT  - Journal Article
DEP - 20200512
PL  - England
TA  - Sci Rep
JT  - Scientific reports
JID - 101563288
RN  - 0 (Apolipoproteins M)
SB  - IM
MH  - Aged
MH  - Alleles
MH  - Apolipoproteins M/*genetics/metabolism
MH  - Diabetes Mellitus, Type 2/diagnosis/*genetics
MH  - Female
MH  - Gene Frequency
MH  - Genetic Predisposition to Disease/*genetics
MH  - Genotype
MH  - Haplotypes
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Obesity/diagnosis/*genetics
MH  - *Polymorphism, Single Nucleotide
MH  - Protein Binding
MH  - Risk Factors
PMC - PMC7217861
COIS- The authors declare no competing interests.
EDAT- 2020/05/14 06:00
MHDA- 2020/12/01 06:00
PMCR- 2020/05/12
CRDT- 2020/05/14 06:00
PHST- 2019/10/08 00:00 [received]
PHST- 2020/03/31 00:00 [accepted]
PHST- 2020/05/14 06:00 [entrez]
PHST- 2020/05/14 06:00 [pubmed]
PHST- 2020/12/01 06:00 [medline]
PHST- 2020/05/12 00:00 [pmc-release]
AID - 10.1038/s41598-020-64467-6 [pii]
AID - 64467 [pii]
AID - 10.1038/s41598-020-64467-6 [doi]
PST - epublish
SO  - Sci Rep. 2020 May 12;10(1):7859. doi: 10.1038/s41598-020-64467-6.