PMID- 32400115
OWN - NLM
STAT- MEDLINE
DCOM- 20210809
LR  - 20210809
IS  - 1522-726X (Electronic)
IS  - 1522-1946 (Linking)
VI  - 96
IP  - 7
DP  - 2020 Dec
TI  - Effect of concomitant aortic regurgitation on early hypo-attenuated leaflet 
      thickening after transcatheter aortic valve replacement in patients with 
      symptomatic severe aortic stenosis.
PG  - 1491-1497
LID - 10.1002/ccd.28903 [doi]
AB  - OBJECTIVE: We hypothesize that different degree of pre-existing aortic 
      regurgitation (AR) may affect the presence of hypo-attenuated leaflet thickening 
      (HALT) after transcatheter aortic valve replacement (TAVR). BACKGROUND: The 
      mechanism of the presence of HALT post-TAVR is not fully understood. METHODS: We 
      retrospectively evaluated the post-procedural multi-slice computed tomography 
      (MSCT) before discharge for evidence of HALT. Patients were grouped according to 
      the degree of pre-existing AR. Baseline, native anatomy and procedure details 
      were compared, then multivariate regression was performed. RESULTS: MSCT analyzed 
      was performed at a median of 6 days post-TAVR in 179 patients. HALT was detected 
      in 10.6% of patients. After adjusting for variables that were significantly 
      different between groups, pre-existing >/= moderate AR was protective to the risk 
      of HALT (OR 0.15, 95% CI 0.03-0.84, p = .03). Stratifying for factors that might 
      explain the impact of pre-existing AR on HALT, patients with a small Sinus of 
      Valsalva, non-eccentric remodeling and receiving a large bioprosthesis 
      experienced a sevenfold higher risk for HALT (OR 7.16, 95% CI 2.05-25.08, p = 
      .002). CONCLUSIONS: Patients underwent TAVR with pre-existing >/= moderate AR 
      appeared to experience a lower incidence of early HALT compared to those patients 
      with less than moderate AR, which may be explained by a larger Sinus of Valsalva 
      and a higher proportion of LV eccentric remodeling.
CI  - (c) 2020 Wiley Periodicals, Inc.
FAU - Xiong, Tian-Yuan
AU  - Xiong TY
AUID- ORCID: 0000-0001-8054-3512
AD  - Department of Cardiology, West China Hospital, Sichuan University, Chengdu, PR 
      China.
FAU - Liao, Yan-Biao
AU  - Liao YB
AD  - Department of Cardiology, West China Hospital, Sichuan University, Chengdu, PR 
      China.
FAU - Li, Yi-Jian
AU  - Li YJ
AUID- ORCID: 0000-0002-3755-5961
AD  - Department of Cardiology, West China Hospital, Sichuan University, Chengdu, PR 
      China.
FAU - Chen, Fei
AU  - Chen F
AD  - Department of Cardiology, West China Hospital, Sichuan University, Chengdu, PR 
      China.
FAU - Li, Xi
AU  - Li X
AUID- ORCID: 0000-0002-3018-618X
AD  - Department of Cardiology, West China Hospital, Sichuan University, Chengdu, PR 
      China.
FAU - Wang, Zi-Jie
AU  - Wang ZJ
AD  - Department of Cardiology, West China Hospital, Sichuan University, Chengdu, PR 
      China.
FAU - Wang, Xi
AU  - Wang X
AD  - Department of Cardiology, West China Hospital, Sichuan University, Chengdu, PR 
      China.
FAU - Ou, Yuanweixiang
AU  - Ou Y
AD  - Department of Cardiology, West China Hospital, Sichuan University, Chengdu, PR 
      China.
FAU - Li, Qiao
AU  - Li Q
AD  - Department of Cardiology, West China Hospital, Sichuan University, Chengdu, PR 
      China.
FAU - Wei, Jia-Fu
AU  - Wei JF
AD  - Department of Cardiology, West China Hospital, Sichuan University, Chengdu, PR 
      China.
FAU - Peng, Yong
AU  - Peng Y
AD  - Department of Cardiology, West China Hospital, Sichuan University, Chengdu, PR 
      China.
FAU - Meng, Wei
AU  - Meng W
AD  - Department of Cardiovascular Surgery, West China Hospital, Sichuan University, 
      Chengdu, PR China.
FAU - Feng, Yuan
AU  - Feng Y
AD  - Department of Cardiology, West China Hospital, Sichuan University, Chengdu, PR 
      China.
FAU - Chen, Mao
AU  - Chen M
AD  - Department of Cardiology, West China Hospital, Sichuan University, Chengdu, PR 
      China.
LA  - eng
PT  - Journal Article
DEP - 20200513
PL  - United States
TA  - Catheter Cardiovasc Interv
JT  - Catheterization and cardiovascular interventions : official journal of the 
      Society for Cardiac Angiography & Interventions
JID - 100884139
SB  - IM
CIN - Catheter Cardiovasc Interv. 2020 Dec;96(7):1498-1499. PMID: 33306885
MH  - Aged
MH  - Aged, 80 and over
MH  - Aortic Valve/diagnostic imaging/physiopathology/*surgery
MH  - Aortic Valve Insufficiency/diagnostic imaging/physiopathology/*surgery
MH  - Aortic Valve Stenosis/diagnostic imaging/physiopathology/*surgery
MH  - Female
MH  - Hemodynamics
MH  - Humans
MH  - Male
MH  - Retrospective Studies
MH  - Severity of Illness Index
MH  - Time Factors
MH  - *Transcatheter Aortic Valve Replacement/adverse effects
MH  - Treatment Outcome
MH  - Ventricular Function, Left
MH  - Ventricular Remodeling
OTO - NOTNLM
OT  - aortic regurgitation
OT  - aortic stenosis
OT  - hypo-attenuated leaflet thickening
OT  - transcatheter aortic valve implantation
EDAT- 2020/05/14 06:00
MHDA- 2021/08/10 06:00
CRDT- 2020/05/14 06:00
PHST- 2020/01/21 00:00 [received]
PHST- 2020/03/12 00:00 [revised]
PHST- 2020/03/30 00:00 [accepted]
PHST- 2020/05/14 06:00 [pubmed]
PHST- 2021/08/10 06:00 [medline]
PHST- 2020/05/14 06:00 [entrez]
AID - 10.1002/ccd.28903 [doi]
PST - ppublish
SO  - Catheter Cardiovasc Interv. 2020 Dec;96(7):1491-1497. doi: 10.1002/ccd.28903. 
      Epub 2020 May 13.