PMID- 32401626
OWN - NLM
STAT- MEDLINE
DCOM- 20201007
LR  - 20201007
IS  - 1522-1490 (Electronic)
IS  - 0363-6119 (Linking)
VI  - 318
IP  - 6
DP  - 2020 Jun 1
TI  - Combined effects of moderate exercise and short-term fasting on markers of immune 
      function in healthy human subjects.
PG  - R1103-R1115
LID - 10.1152/ajpregu.00341.2019 [doi]
AB  - This study aimed to investigate the effects of a short-term (36 h) fasting period 
      combined with an acute bout of exercise on markers of immune function and 
      inflammation in healthy human subjects. Fourteen moderately trained male subjects 
      (aged 19-39 yr) participated in a 36-h fasting trial (FA-T), followed by an acute 
      bout of moderate exercise (60% V̇o(2max)). After 1 wk, the same subjects, as 
      their own control, participated in a nonfasting trial (NFA-T) in which they 
      performed an exercise trial of the same duration and intensity. Blood samples 
      were taken before, immediately after, and 1 h after each exercise bout and 
      analyzed for several immunological and metabolic markers. At baseline, fasting 
      subjects showed lower levels of T cell apoptosis, lymphocyte-proliferative 
      responses, IL-6, monocyte chemoattractant protein-1 (MCP-1), insulin, and leptin 
      (P < 0.05) as well as higher levels of neutrophil oxidative burst and 
      thiobarbituric acid reactive substances (TBARS) than those in the NFA-T (P < 
      0.05). After the exercise protocol, fasted subjects revealed higher T cell 
      apoptosis, neutrophil oxidative burst, TBARS, TNFalpha, and MCP-1 levels as well as 
      lower levels of lymphocyte-proliferative response, IL-6, insulin, and leptin than 
      those in the NFA-T (P < 0.05). Short-term fasting aggravates perturbations in 
      markers of immune function, and inflammation was induced by an acute 
      moderate-intensity exercise protocol.
FAU - Mooren, Frank C
AU  - Mooren FC
AD  - Witten/Herdecke University, Faculty of Health/School of Medicine, Witten, 
      Germany.
FAU - Krueger, Karsten
AU  - Krueger K
AD  - Department of Exercise Physiology and Sports Therapy, Justus-Liebig-University, 
      Giessen, Germany.
FAU - Ringseis, Robert
AU  - Ringseis R
AD  - Institute of Animal Nutrition and Nutrition Physiology, Justus-Liebig-University, 
      Giessen, Germany.
FAU - Eder, Klaus
AU  - Eder K
AD  - Institute of Animal Nutrition and Nutrition Physiology, Justus-Liebig-University, 
      Giessen, Germany.
FAU - Liebisch, Gerhard
AU  - Liebisch G
AUID- ORCID: 0000-0003-4886-0811
AD  - Institute of Clinical Chemistry and Laboratory Medicine, University Hospital, 
      Regensburg, Germany.
FAU - Conrad, Kerstin
AU  - Conrad K
AD  - Department of Exercise Physiology and Sports Therapy, Justus-Liebig-University, 
      Giessen, Germany.
FAU - Alack, Katharina
AU  - Alack K
AD  - Department of Exercise Physiology and Sports Therapy, Justus-Liebig-University, 
      Giessen, Germany.
FAU - Hajizadeh Maleki, Behzad
AU  - Hajizadeh Maleki B
AD  - Department of Exercise Physiology and Sports Therapy, Justus-Liebig-University, 
      Giessen, Germany.
LA  - eng
PT  - Journal Article
DEP - 20200513
PL  - United States
TA  - Am J Physiol Regul Integr Comp Physiol
JT  - American journal of physiology. Regulatory, integrative and comparative 
      physiology
JID - 100901230
RN  - 0 (Biomarkers)
RN  - 0 (Chemokine CCL2)
RN  - 0 (Insulin)
RN  - 0 (Interleukin-6)
RN  - 0 (Leptin)
RN  - 0 (Thiobarbituric Acid Reactive Substances)
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Adult
MH  - Apoptosis/physiology
MH  - Biomarkers/blood
MH  - Chemokine CCL2/blood
MH  - Exercise/*physiology
MH  - Fasting/*blood
MH  - Healthy Volunteers
MH  - Humans
MH  - Inflammation/*blood
MH  - Insulin/blood
MH  - Interleukin-6/blood
MH  - Leptin/blood
MH  - Male
MH  - Oxidative Stress/physiology
MH  - Thiobarbituric Acid Reactive Substances/metabolism
MH  - Tumor Necrosis Factor-alpha/blood
MH  - Young Adult
OTO - NOTNLM
OT  - apoptosis
OT  - exercise
OT  - fasting
OT  - immune function
OT  - lymphocyte
EDAT- 2020/05/14 06:00
MHDA- 2020/10/08 06:00
CRDT- 2020/05/14 06:00
PHST- 2020/05/14 06:00 [pubmed]
PHST- 2020/10/08 06:00 [medline]
PHST- 2020/05/14 06:00 [entrez]
AID - 10.1152/ajpregu.00341.2019 [doi]
PST - ppublish
SO  - Am J Physiol Regul Integr Comp Physiol. 2020 Jun 1;318(6):R1103-R1115. doi: 
      10.1152/ajpregu.00341.2019. Epub 2020 May 13.