PMID- 32402852
OWN - NLM
STAT- MEDLINE
DCOM- 20201027
LR  - 20201027
IS  - 1095-8673 (Electronic)
IS  - 0022-4804 (Linking)
VI  - 253
DP  - 2020 Sep
TI  - Thyroid Function Modulates Lung Fluid and Alveolar Viscoelasticity in 
      Mechanically Ventilated Rat.
PG  - 272-279
LID - S0022-4804(20)30194-3 [pii]
LID - 10.1016/j.jss.2020.03.060 [doi]
AB  - BACKGROUND: Mechanical ventilation (MV) is life saving; yet it may induce severe 
      lung injury and lead to multisystem organ failure and death. Thyroid hormones 
      (THs) promote alveolar fluid clearance and alleviates hypoxia-induced lung 
      injury. Given that the mechanism involved in hypoxia-induced lung injury is 
      different from that of ventilator-induced lung injury, we examined the effects of 
      thyroid function on lung extravascular fluid (LF), aquaporin 5 (AQP 5) 
      expression, and alveolar viscoelasticity (AVE) in mechanically ventilated rat. 
      METHODS: Hypothyroid (hypo) and hyperthyroid (hyper) animals were generated by 
      administration of metimazole and L-thyroxine, respectively. Lung injury was 
      induced by high-tidal volume MV. The LF was estimated by lung wet weight-to-dry 
      weight ratio assessment. Expression of AQP 5 was evaluated by western blotting 
      and in situ immunohistochemistry. The AVE was judged by elastic lung 
      pressure/volume curve recording. RESULTS: Injurious MV significantly reduced lung 
      AQP 5 expression and altered LF and AVE in a thyroid function-dependent manner. 
      Regardless of animals' ventilation mode, hyper state caused significant 
      reductions in LF and lung AQP 5 protein. It also improved AVE irrespective of 
      animals' ventilation mode. The effects of hypo condition on LF, AQP 5 expression, 
      and AVE were in contrast to that of hyper state. CONCLUSIONS: These data indicate 
      that thyroid function has profound effects on LF, AQP 5, and AVE in mechanically 
      ventilated lungs. Given that the effects of thyroidal status were as prominent as 
      that of injurious MV, we suggest that thyroid function should be considered when 
      patients are to be subjected to MV.
CI  - Copyright (c) 2020 Elsevier Inc. All rights reserved.
FAU - Owji, Mohammad S
AU  - Owji MS
AD  - Department of Pathology, School of Medicine, Shiraz University of Medical 
      Sciences, Shiraz, Iran.
FAU - Varedi, Masoumeh
AU  - Varedi M
AD  - Department of Physiology, School of Medicine, Shiraz University of Medical 
      Sciences, Shiraz, Iran. Electronic address: varedim@sums.ac.ir.
FAU - Naghibalhossaini, Fakhraddin
AU  - Naghibalhossaini F
AD  - Department of Biochemistry, School of Medicine, Shiraz University of Medical 
      Sciences, Shiraz, Iran.
FAU - Pajouhi, Nasser
AU  - Pajouhi N
AD  - Department of Physiology, Faculty of Medicine, Lorestan University of Medical 
      Sciences, Khorramabad, Lorestan, Iran.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20200508
PL  - United States
TA  - J Surg Res
JT  - The Journal of surgical research
JID - 0376340
RN  - 0 (Antithyroid Agents)
RN  - 0 (Aqp5 protein, rat)
RN  - 0 (Aquaporin 5)
RN  - 0 (Thyroid Hormones)
RN  - 554Z48XN5E (Methimazole)
RN  - Q51BO43MG4 (Thyroxine)
SB  - IM
MH  - Animals
MH  - Antithyroid Agents/administration & dosage
MH  - Aquaporin 5/analysis/metabolism
MH  - Disease Models, Animal
MH  - Elasticity
MH  - Humans
MH  - Male
MH  - Methimazole/administration & dosage
MH  - Pulmonary Alveoli/*physiopathology
MH  - Rats
MH  - Respiration, Artificial/*adverse effects
MH  - Thyroid Gland/drug effects/*metabolism
MH  - Thyroid Hormones/*metabolism
MH  - Thyroxine/administration & dosage
MH  - Tidal Volume
MH  - Ventilator-Induced Lung Injury/etiology/*metabolism/physiopathology
MH  - Viscosity
OTO - NOTNLM
OT  - AQP 5
OT  - Lung fluid and compliance
OT  - Thyroid hormone
OT  - Ventilator-induced lung injury
EDAT- 2020/05/14 06:00
MHDA- 2020/10/28 06:00
CRDT- 2020/05/14 06:00
PHST- 2019/08/14 00:00 [received]
PHST- 2020/02/23 00:00 [revised]
PHST- 2020/03/30 00:00 [accepted]
PHST- 2020/05/14 06:00 [pubmed]
PHST- 2020/10/28 06:00 [medline]
PHST- 2020/05/14 06:00 [entrez]
AID - S0022-4804(20)30194-3 [pii]
AID - 10.1016/j.jss.2020.03.060 [doi]
PST - ppublish
SO  - J Surg Res. 2020 Sep;253:272-279. doi: 10.1016/j.jss.2020.03.060. Epub 2020 May 
      8.