PMID- 32403259 OWN - NLM STAT- MEDLINE DCOM- 20210204 LR - 20210204 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 12 IP - 5 DP - 2020 May 11 TI - Effects of 120 g/h of Carbohydrates Intake during a Mountain Marathon on Exercise-Induced Muscle Damage in Elite Runners. LID - 10.3390/nu12051367 [doi] LID - 1367 AB - Background-exercise-induced muscle damage (EIMD) and internal exercise load are increased after competing in ultraendurance events such as mountain marathons. Adequate carbohydrate (CHO) intake during exercise optimizes athletic performance and could limit EIMD, reduce internal exercise load and, thus, improve recovery. Therefore, the aim of this study was to research into and compare the effects of high CHO intake (120 g/h) in terms of CHO intake recommendation (90 g/h) and regular CHO intake performed by ultraendurance athletes (60 g/h) during a mountain marathon, on exercise load and EIMD markers (creatine kinase (CK), lactate dehydrogenase (LDH), glutamic oxaloacetic transaminase (GOT), urea and creatinine). Materials and Methods-a randomized trial was carried out on 20 male elite runners who had previously undertaken nutritional and gut training, and who consumed different CHO dosages according to experimental (EXP-120 g/h), control (CON-90 g/h) and low CHO intake (LOW-60 g/h) groups during a ~4000 m cumulative slope mountain marathon. EIMD markers were analyzed before the race and 24 h afterwards. Internal exercise load was calculated based on rate of perceived exertion (RPE) during and after the marathon event. Results-internal exercise load during the mountain marathon was significantly lower (p = 0.019; eta(2)p = 0.471) in EXP (3805 +/- 281 AU) compared to LOW (4688 +/- 705 AU) and CON (4692 +/- 716 AU). Moreover, results revealed that the EXP group evidenced significantly lower CK (p = 0.019; eta(2)p = 0.373), LDH (p < 0.001; eta(2)p = 0.615) and GOT (p = 0.003; eta(2)p = 0.500) values 24 h after the mountain marathon race compared to LOW and CON. Along these lines, EIMD and exercise load evidenced a close correlation (R = 0.742; p < 0.001). Conclusion: High CHO intake (120 g/h) during a mountain marathon could limit the EIMD observed by CK, LDH and GOT and internal exercise load compared to CHO ingestion of 60 and 90 g/h. FAU - Viribay, Aitor AU - Viribay A AD - Glut4Science, Physiology, Nutrition and Sport, 01004 Vitoria-Gasteiz, Spain. FAU - Arribalzaga, Soledad AU - Arribalzaga S AD - Institute of Biomedicine (IBIOMED), Physiotherapy Department, University of Leon, Campus de Vegazana, 24071 Leon, Spain. FAU - Mielgo-Ayuso, Juan AU - Mielgo-Ayuso J AUID- ORCID: 0000-0002-6554-4602 AD - Department of Biochemistry Molecular Biology and Physiology, Faculty of Health Sciences, University of Valladolid, 42004 Soria, Spain. FAU - Castaneda-Babarro, Arkaitz AU - Castaneda-Babarro A AD - Health, Physical Activity and Sports Science Laboratory, Department of Physical Activity and Sports, Faculty of Psychology and Education, University of Deusto, 48007 Bizkaia, Spain. FAU - Seco-Calvo, Jesus AU - Seco-Calvo J AUID- ORCID: 0000-0002-7818-9777 AD - Institute of Biomedicine (IBIOMED), Physiotherapy Department, University of Leon, Researcher at the Basque Country University, Campus de Vegazana, 24071 Leon, Spain. FAU - Urdampilleta, Aritz AU - Urdampilleta A AD - Centro de Investigacion y de Formacion ElikaEsport, 08290 Cerdanyola del Valles, Barcelona, Spain. LA - eng PT - Comparative Study PT - Journal Article PT - Randomized Controlled Trial DEP - 20200511 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 RN - 0 (Dietary Carbohydrates) RN - 8W8T17847W (Urea) RN - AYI8EX34EU (Creatinine) RN - EC 1.1.1.27 (L-Lactate Dehydrogenase) RN - EC 2.6.1.1 (Aspartate Aminotransferases) RN - EC 2.7.3.2 (Creatine Kinase) SB - IM MH - Adult MH - Aspartate Aminotransferases/blood MH - Athletic Performance/physiology MH - Creatine Kinase/blood MH - Creatinine/blood MH - Dietary Carbohydrates/*administration & dosage MH - Exercise/*physiology MH - Humans MH - L-Lactate Dehydrogenase/blood MH - Male MH - Marathon Running/*physiology MH - Middle Aged MH - Muscle, Skeletal/drug effects/physiopathology MH - Muscular Diseases/etiology/physiopathology/*prevention & control MH - Physical Endurance/drug effects/physiology MH - Urea/blood PMC - PMC7284742 OTO - NOTNLM OT - athletic performance OT - dietary intake OT - glycogen OT - muscle recovery COIS- The authors declare no conflict of interest. EDAT- 2020/05/15 06:00 MHDA- 2021/02/05 06:00 PMCR- 2020/05/01 CRDT- 2020/05/15 06:00 PHST- 2020/04/16 00:00 [received] PHST- 2020/05/07 00:00 [revised] PHST- 2020/05/09 00:00 [accepted] PHST- 2020/05/15 06:00 [entrez] PHST- 2020/05/15 06:00 [pubmed] PHST- 2021/02/05 06:00 [medline] PHST- 2020/05/01 00:00 [pmc-release] AID - nu12051367 [pii] AID - nutrients-12-01367 [pii] AID - 10.3390/nu12051367 [doi] PST - epublish SO - Nutrients. 2020 May 11;12(5):1367. doi: 10.3390/nu12051367.