PMID- 32403934
OWN - NLM
STAT- MEDLINE
DCOM- 20210427
LR  - 20210427
IS  - 2048-8734 (Electronic)
IS  - 2048-8726 (Print)
IS  - 2048-8726 (Linking)
VI  - 9
IP  - 4
DP  - 2020 Jun
TI  - Pentraxin 3 in primary percutaneous coronary intervention for ST elevation 
      myocardial infarction is associated with early irreversible myocardial damage : 
      Kinetic profile, relationship to interleukin 6 and infarct size.
PG  - 302-312
LID - 10.1177/2048872620923641 [doi]
AB  - BACKGROUND: The inflammatory marker long pentraxin 3 (PTX3) has been shown to be 
      a strong predictor of 30-day and one-year mortality after acute myocardial 
      infarction. The aim of this study was to evaluate the kinetic profile of PTX3 and 
      its relationship with interleukin 6 (IL-6), high-sensitive C-reactive protein 
      (hs-CRP) and infarct size. METHODS: PTX3, IL-6 and hs-CRP were measured at 
      predefined time points, at baseline (before percutaneous coronary intervention 
      (PCI)), at 12 and 72 hours after PCI in 161 patients with first-time ST elevation 
      myocardial infarction (STEMI). RESULTS: PTX3 and IL-6 levels increased in the 
      early phase, followed by a gradual decrease between 12 and 72 hours. There were 
      statistically significant correlations between PTX3 and IL-6 in general, for all 
      time points and for changes over time (0-72 hours). In a linear mixed model, PTX3 
      predicted IL-6 (p < 0.001). PTX3 is also correlated with hs-CRP in general, and 
      at each time point post PCI, except at baseline. PTX3, IL-6 and hs-CRP were all 
      significantly correlated with infarct size in general, and at the peak time point 
      for maximum troponin I. In addition, there was a modest correlation between IL-6 
      levels at baseline and infarct size at 72 hours after PCI (rho = 0.23, p = 0.006). 
      CONCLUSIONS: PTX3 had a similar kinetic profile to IL-6, with an early increase 
      and decline, and was statistically significantly correlated with markers of 
      infarct size in STEMI patients post primary PCI. Baseline levels of IL-6 only 
      predicted infarct size at 72 hours post PCI.
FAU - Butt, Noreen
AU  - Butt N
AD  - Department of Clinical Science, University of Bergen, Norway.
AD  - Department of Cardiology, Stavanger University Hospital, Norway.
FAU - Bache-Mathiesen, L K
AU  - Bache-Mathiesen LK
AD  - Department of Research, Section of Biostatistics Stavanger, University Hospital, 
      Norway.
FAU - Ushakova, A
AU  - Ushakova A
AD  - Department of Research, Section of Biostatistics Stavanger, University Hospital, 
      Norway.
FAU - Nordrehaug, J E
AU  - Nordrehaug JE
AD  - Department of Clinical Science, University of Bergen, Norway.
AD  - Department of Cardiology, Stavanger University Hospital, Norway.
FAU - Jensen, S E
AU  - Jensen SE
AD  - Cardiology, Aalborg University Hospital, Denmark.
FAU - Munk, P S
AU  - Munk PS
AD  - Department of Cardiology, Sorlandet Hospital, Norway.
FAU - Danchin, N
AU  - Danchin N
AD  - Cardiology, Hopital Europeen Georges Pompidou, Universite Paris Descartes, 
      France.
FAU - Dubois-Rande, J L
AU  - Dubois-Rande JL
AD  - Cardiology and Clinical Investigation Center, University Hospital Henri Mondor, 
      France.
FAU - Hansen, H S
AU  - Hansen HS
AD  - Odense University Hospital, Denmark.
FAU - Paganelli, F
AU  - Paganelli F
AD  - Hospital Nord of Marseille, France.
FAU - Corvoisier, P Le
AU  - Corvoisier PL
AD  - Cardiology and Clinical Investigation Center, University Hospital Henri Mondor, 
      France.
FAU - Firat, H
AU  - Firat H
AD  - Firalis SA, France.
FAU - Erlinge, D
AU  - Erlinge D
AD  - Lund University, Sweden.
FAU - Atar, D
AU  - Atar D
AD  - Department of Cardiology, Oslo University Hospital Ulleval and University of 
      Oslo, Norway.
FAU - Larsen, A I
AU  - Larsen AI
AD  - Department of Clinical Science, University of Bergen, Norway.
AD  - Department of Cardiology, Stavanger University Hospital, Norway.
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
PT  - Randomized Controlled Trial
DEP - 20200514
PL  - England
TA  - Eur Heart J Acute Cardiovasc Care
JT  - European heart journal. Acute cardiovascular care
JID - 101591369
RN  - 0 (Biomarkers)
RN  - 0 (Interleukin-6)
RN  - 0 (Serum Amyloid P-Component)
RN  - 0 (Troponin I)
RN  - 0 (Troponin T)
RN  - 148591-49-5 (PTX3 protein)
RN  - 9007-41-4 (C-Reactive Protein)
SB  - IM
MH  - Aged
MH  - Biomarkers/blood
MH  - C-Reactive Protein/*metabolism
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Interleukin-6/*blood
MH  - Male
MH  - Middle Aged
MH  - Myocardium/*metabolism
MH  - *Percutaneous Coronary Intervention
MH  - Retrospective Studies
MH  - ST Elevation Myocardial Infarction/*blood/diagnosis/surgery
MH  - Serum Amyloid P-Component/*metabolism
MH  - Severity of Illness Index
MH  - Troponin I/blood
MH  - Troponin T/blood
PMC - PMC7549329
OTO - NOTNLM
OT  - STEMI
OT  - high-sensitive C-reactive protein
OT  - inflammation
OT  - interleukin 6
OT  - pentraxin 3
OT  - primary percutaneous coronary intervention
EDAT- 2020/05/15 06:00
MHDA- 2021/04/28 06:00
PMCR- 2020/10/12
CRDT- 2020/05/15 06:00
PHST- 2020/05/15 06:00 [pubmed]
PHST- 2021/04/28 06:00 [medline]
PHST- 2020/05/15 06:00 [entrez]
PHST- 2020/10/12 00:00 [pmc-release]
AID - 10.1177_2048872620923641 [pii]
AID - 10.1177/2048872620923641 [doi]
PST - ppublish
SO  - Eur Heart J Acute Cardiovasc Care. 2020 Jun;9(4):302-312. doi: 
      10.1177/2048872620923641. Epub 2020 May 14.