PMID- 32405346
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220414
IS  - 2008-3866 (Print)
IS  - 2008-3874 (Electronic)
IS  - 2008-3866 (Linking)
VI  - 23
IP  - 1
DP  - 2020 Jan
TI  - Therapeutic effects of organic zinc on reproductive hormones, insulin resistance 
      and mTOR expression, as a novel component, in a rat model of Polycystic ovary 
      syndrome.
PG  - 36-45
LID - 10.22038/IJBMS.2019.36004.8586 [doi]
AB  - OBJECTIVES: Zinc is an effective factor in the reproductive system. Insulin 
      resistance (IR) is known as an important disorder in patients with polycystic 
      ovary syndrome (PCOS). Mammalian target of rapamycin (mTOR), which controls key 
      cell activities, in particular, is activated in disorders such as PCOS. The 
      present study was conducted to observe the therapeutic effects of organic zinc on 
      IR, mTOR gene expression, and pathogenesis of PCOS in a rat model induced-PCOS. 
      MATERIALS AND METHODS: Experimental treatments were performed on control and 
      treated groups, consisting of healthy controls (Control, water, and standard feed 
      intake and daily injection of sesame oil alone), Polycystic control (PCO, 
      injection of 4 mg/kg estradiol valerate (EV) for four weeks). Treated groups 
      (PCO-ZM 25, PCO-ZM 75, and PCO-ZM 175) after 4 weeks of receiving EV, were daily 
      given three levels of 25, 75, and 175 mg zinc methionine/kg BW for 15 days, 
      respectively. RESULTS: Injection of EV dramatically increased body and ovarian 
      weights, levels of LH, testosterone, estradiol, triglyceride, fasting insulin, 
      fasting glucose, HOMA-IR, IGF-1, gene expression of mTOR, and number of cysts 
      (P<0.05). It also reduced the level of progesterone, HDL-C, and the number of 
      antral follicles (P<0.05). However, by increasing zinc-methionine application 
      especially at 175 mg/kg BW, the induction effects of EV were improved on ovarian 
      cysts (P<0.05). CONCLUSION: Organic zinc showed beneficial effects in the EV 
      induced PCOS rats via decreased insulin resistance and mTOR expression, restored 
      the hormonal profile, and decreased the number of cysts in the ovaries.
FAU - Fazel Torshizi, Faeze
AU  - Fazel Torshizi F
AD  - Department of Animal Science, Science and Research Branch, Islamic Azad 
      University, Tehran, Iran.
FAU - Chamani, Mohammad
AU  - Chamani M
AD  - Department of Animal Science, Science and Research Branch, Islamic Azad 
      University, Tehran, Iran.
FAU - Khodaei, Hamid Reza
AU  - Khodaei HR
AD  - Department of Animal Sciences, Islamic Azad University, Golpayegan Branch, 
      Isfahan, Iran.
FAU - Sadeghi, Ali Asghar
AU  - Sadeghi AA
AD  - Department of Animal Science, Science and Research Branch, Islamic Azad 
      University, Tehran, Iran.
FAU - Hejazi, Seyed Hossein
AU  - Hejazi SH
AD  - Skin Disease and Leishmaniasis Research Center, Department of Parasitology and 
      Mycology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, 
      Iran.
FAU - Majidzadeh Heravi, Reza
AU  - Majidzadeh Heravi R
AD  - Department of Animal Sciences, Ferdowsi University of Mashhad, Mashhad, Iran.
LA  - eng
PT  - Journal Article
PL  - Iran
TA  - Iran J Basic Med Sci
JT  - Iranian journal of basic medical sciences
JID - 101517966
PMC - PMC7206839
OTO - NOTNLM
OT  - Insulin resistance
OT  - Polycystic ovary syndrome
OT  - Rat
OT  - Zinc-methionine
OT  - mTOR
EDAT- 2020/05/15 06:00
MHDA- 2020/05/15 06:01
PMCR- 2020/01/01
CRDT- 2020/05/15 06:00
PHST- 2020/05/15 06:00 [entrez]
PHST- 2020/05/15 06:00 [pubmed]
PHST- 2020/05/15 06:01 [medline]
PHST- 2020/01/01 00:00 [pmc-release]
AID - 10.22038/IJBMS.2019.36004.8586 [doi]
PST - ppublish
SO  - Iran J Basic Med Sci. 2020 Jan;23(1):36-45. doi: 10.22038/IJBMS.2019.36004.8586.