PMID- 32405455
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220414
IS  - 2213-4220 (Print)
IS  - 2213-4239 (Electronic)
IS  - 2213-4220 (Linking)
VI  - 9
IP  - 2
DP  - 2020 Jun
TI  - Ephedrae Herba in combination with herbal medicine (Zhizichi decoction and 
      Phellodendri Cortex) for weight reduction: a case series.
PG  - 100408
LID - 10.1016/j.imr.2020.100408 [doi]
LID - 100408
AB  - BACKGROUNDS: Ephedrae Herba is widely used to treat obesity. There is a concern 
      for adverse events (AEs) using it and we need to develop strategies to attenuate 
      it without its effectiveness for weight-reducing potential. We investigated the 
      effects of a combination of Ephedra Herba with Zhizichi decoction and 
      Phellodendri Cortex (Anmyungambi (AMGB) decoction) in reducing the incidence of 
      Ephedra Herba-related AEs. METHODS: We performed a retrospective chart review 
      from a clinical case series of patients visiting the Jaonmi Korean Medicine 
      Clinic (Seoul, Korea). The inclusion criteria was patients who were prescribed 
      AMGB decoction, (containing Ephedrae Herba, Phellodendri Cortex, and Zhizichi 
      decoction [Gardeniae Fructus, and Glycine Semen Preparata] in different 
      proportions) for weight reduction. Exclusion of Phellodendri Cortex in the 
      original AMGB preparation was allowed; conventional medications, acupuncture, and 
      dietary supplements were not allowed. The primary outcome was absolute weight 
      loss at the end of treatment. RESULTS: Twenty-seven patients (6 men and 21 
      women), aged 18-75 years (mean age, 42.6 +/- 11.1 years) and the average treatment 
      duration was 39.4 days. Absolute weight loss at the end of treatment was 
      4.49 +/- 2.40 kg. Fifteen patients lost more than 5% weight (55.6%). Treatment >45 
      days resulted in significantly greater weight loss compared to treatment <30 days 
      (p < 0.001). Not severe AEs were reported in 16 patients including constipation, 
      fatigue, etc. CONCLUSION: A combination of Ephedra Herba with Zhizichi decoction 
      and Phellodendri Cortex may be a safe and effective treatment for weight 
      reduction in obese and overweight patients.
CI  - (c) 2020 Korea Institute of Oriental Medicine. Publishing services by Elsevier B.V.
FAU - Lee, Eunji
AU  - Lee E
AD  - Chung-Yeon Korean Medicine Hospital, Gwangju, Republic of Korea.
AD  - Chung-Yeon Central Institute, Gwangju, Republic of Korea.
FAU - Yoon, Sang-Hoon
AU  - Yoon SH
AD  - Chung-Yeon Korean Medicine Hospital, Gwangju, Republic of Korea.
AD  - Chung-Yeon Central Institute, Gwangju, Republic of Korea.
FAU - Kim, Hyunho
AU  - Kim H
AD  - Chung-Yeon Central Institute, Gwangju, Republic of Korea.
AD  - Dongshin Korean Medicine Hospital, Seoul, Republic of Korea.
FAU - Kim, Young Doo
AU  - Kim YD
AD  - Jaonmi Korean Medicine Clinic, Seoul, Republic of Korea.
FAU - Leem, Jungtae
AU  - Leem J
AD  - Chung-Yeon Central Institute, Gwangju, Republic of Korea.
AD  - Dongshin Korean Medicine Hospital, Seoul, Republic of Korea.
FAU - Park, Jinbong
AU  - Park J
AD  - Department of Pharmacology, College of Korean Medicine, Kyung Hee University, 
      Seoul, Republic of Korea.
LA  - eng
PT  - Case Reports
DEP - 20200329
PL  - Netherlands
TA  - Integr Med Res
JT  - Integrative medicine research
JID - 101612707
PMC - PMC7210583
OTO - NOTNLM
OT  - Case report
OT  - Ephedrae Herba
OT  - Korean traditional medicine
OT  - Obesity
OT  - Safety
EDAT- 2020/05/15 06:00
MHDA- 2020/05/15 06:01
PMCR- 2020/03/29
CRDT- 2020/05/15 06:00
PHST- 2019/12/23 00:00 [received]
PHST- 2020/03/22 00:00 [revised]
PHST- 2020/03/22 00:00 [accepted]
PHST- 2020/05/15 06:00 [entrez]
PHST- 2020/05/15 06:00 [pubmed]
PHST- 2020/05/15 06:01 [medline]
PHST- 2020/03/29 00:00 [pmc-release]
AID - S2213-4220(20)30040-8 [pii]
AID - 100408 [pii]
AID - 10.1016/j.imr.2020.100408 [doi]
PST - ppublish
SO  - Integr Med Res. 2020 Jun;9(2):100408. doi: 10.1016/j.imr.2020.100408. Epub 2020 
      Mar 29.