PMID- 32407973
OWN - NLM
STAT- MEDLINE
DCOM- 20210514
LR  - 20210514
IS  - 1873-7544 (Electronic)
IS  - 0306-4522 (Linking)
VI  - 438
DP  - 2020 Jul 1
TI  - Early Exercise after Intracerebral Hemorrhage Inhibits Inflammation and Promotes 
      Neuroprotection in the Sensorimotor Cortex in Rats.
PG  - 86-99
LID - S0306-4522(20)30298-0 [pii]
LID - 10.1016/j.neuroscience.2020.05.003 [doi]
AB  - The present study examined the effect of early exercise on brain damage and 
      recovery of motor function following intracerebral hemorrhage (ICH) in rats. 
      Subjects were randomly assigned to no training after ICH (ICH), no training after 
      sham surgery (SHAM), early treadmill exercise after ICH (ICH + ET), and late 
      treadmill exercise after ICH (ICH + LT) groups. The ICH + ET and ICH + LT groups 
      were trained for seven consecutive days starting on day 2 and day 9 after 
      surgery, respectively. At post surgery day 16, the brain was surgically excised, 
      and lesion volume, cortical thickness, neuronal number, dendritic length, and 
      dendritic complexity were analyzed. Expression levels of IL-1b, TGF-b1, and IGF-1 
      mRNAs in ipsilateral sensorimotor cortex were measured by RT-PCR. The recovery of 
      motor function in the ICH + ET group was the most accelerated. Cortical thickness 
      and neuronal number were significantly higher in the ICH + ET group than the ICH 
      and ICH + LT groups. The length and complexity of dendrites were also 
      significantly greater in the ICH + ET group compared with the ICH and ICH + LT 
      groups. Expression of IL-1b mRNA was significantly lower in the ICH + ET group 
      than that in the ICH group. Collectively, these results suggest that early 
      treadmill exercise after ICH promotes recovery of sensorimotor function by 
      preventing neuronal death and ensuing cortical atrophy and by preserving 
      dendritic structure compared with late treadmill exercise and no exercise. Early 
      exercise may prevent neurodegeneration and functional loss by inhibiting 
      neuroinflammation.
CI  - Copyright (c) 2020 IBRO. Published by Elsevier Ltd. All rights reserved.
FAU - Tamakoshi, Keigo
AU  - Tamakoshi K
AD  - Department of Physical Therapy, Niigata University of Health and Welfare, Japan; 
      Institute for Human Movement and Medical Sciences, Niigata University of Health 
      and Welfare, Japan. Electronic address: tamakoshi@nuhw.ac.jp.
FAU - Hayao, Keishi
AU  - Hayao K
AD  - Department of Physical Therapy, Niigata University of Health and Welfare, Japan; 
      Institute for Human Movement and Medical Sciences, Niigata University of Health 
      and Welfare, Japan.
FAU - Takahashi, Hideaki
AU  - Takahashi H
AD  - Department of Physical Therapy, Niigata University of Health and Welfare, Japan; 
      Institute for Human Movement and Medical Sciences, Niigata University of Health 
      and Welfare, Japan.
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20200511
PL  - United States
TA  - Neuroscience
JT  - Neuroscience
JID - 7605074
RN  - EC 3.4.24.- (Collagenases)
SB  - IM
MH  - Animals
MH  - Cerebral Hemorrhage/complications
MH  - Collagenases
MH  - Exercise Therapy
MH  - Humans
MH  - Inflammation
MH  - *Neuroprotection
MH  - Rats
MH  - Rats, Wistar
MH  - Recovery of Function
MH  - *Sensorimotor Cortex
OTO - NOTNLM
OT  - early exercise
OT  - intracerebral hemorrhage
OT  - motor functional recovery
OT  - neurodegeneration
OT  - neuroinflammation
OT  - sensorimotor cortex
EDAT- 2020/05/15 06:00
MHDA- 2021/05/15 06:00
CRDT- 2020/05/15 06:00
PHST- 2019/08/22 00:00 [received]
PHST- 2020/05/03 00:00 [revised]
PHST- 2020/05/04 00:00 [accepted]
PHST- 2020/05/15 06:00 [pubmed]
PHST- 2021/05/15 06:00 [medline]
PHST- 2020/05/15 06:00 [entrez]
AID - S0306-4522(20)30298-0 [pii]
AID - 10.1016/j.neuroscience.2020.05.003 [doi]
PST - ppublish
SO  - Neuroscience. 2020 Jul 1;438:86-99. doi: 10.1016/j.neuroscience.2020.05.003. Epub 
      2020 May 11.