PMID- 32408168
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20210110
IS  - 2589-0042 (Electronic)
IS  - 2589-0042 (Linking)
VI  - 23
IP  - 5
DP  - 2020 May 22
TI  - Contribution of Prostaglandin Transporter OATP2A1/SLCO2A1 to Placenta-to-Maternal 
      Hormone Signaling and Labor Induction.
PG  - 101098
LID - S2589-0042(20)30283-2 [pii]
LID - 10.1016/j.isci.2020.101098 [doi]
LID - 101098
AB  - We evaluated the contribution of organic anion transporting polypeptide 2A1 
      (OATP2A1/SLCO2A1), a high-affinity carrier for prostaglandins (PGs), to the 
      parturition process. At gestational day (GD) 15.5, OATP2A1 is co-localized with 
      15-hydroxy-PG dehydrogenase in the mouse placental junctional zone and 
      facilitates PG degradation by delivering PGs to the cytoplasm. Slco2a1 (+/-) 
      females mated with Slco2a1 (-/-) males frequently showed elevated circulating 
      progesterone at GD18.5 and delayed parturition. Progesterone receptor inhibition 
      by RU486 treatment at GD18.5 blocked the delay of parturition. In the junctional 
      zone, PGE(2) stimulated placental lactogen II (PL-II) production, resulting in 
      higher expression of PL-II in Slco2a1 (-/-) placenta at GD18.5. Indomethacin 
      treatment at GD15.5 suppressed the PL-II overproduction at GD18.5 in Slco2a1 
      (-/-) embryo-bearing dams, which promoted progesterone withdrawal and corrected 
      the delayed parturition. These results suggest that extracellular PGE(2) 
      reduction by OATP2A1 at mid-pregnancy would be associated with progesterone 
      withdrawal by suppressing PL-II production, triggering parturition onset.
CI  - Copyright (c) 2020 The Author(s). Published by Elsevier Inc. All rights reserved.
FAU - Inagaki, Mai
AU  - Inagaki M
AD  - Faculty of Pharmacy, Keio University, Minato-ku, Tokyo 105-8512, Japan.
FAU - Nishimura, Tomohiro
AU  - Nishimura T
AD  - Faculty of Pharmacy, Keio University, Minato-ku, Tokyo 105-8512, Japan.
FAU - Nakanishi, Takeo
AU  - Nakanishi T
AD  - Faculty of Pharmacy, Takasaki University of Health and Welfare, Takasaki, Gunma 
      370-0033, Japan; Faculty of Pharmaceutical Sciences, Institute of Medical, 
      Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, Ishikawa 
      920-1192, Japan.
FAU - Shimada, Hiroaki
AU  - Shimada H
AD  - Faculty of Pharmacy, Kindai University, Higashiosaka, Osaka 577-8502, Japan.
FAU - Noguchi, Saki
AU  - Noguchi S
AD  - Faculty of Pharmacy, Keio University, Minato-ku, Tokyo 105-8512, Japan.
FAU - Akanuma, Shin-Ichi
AU  - Akanuma SI
AD  - Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, 
      Toyama 930-0194, Japan.
FAU - Tachikawa, Masanori
AU  - Tachikawa M
AD  - Graduate School of Biomedical Sciences, Tokushima University, Tokushima 770-8505, 
      Japan.
FAU - Hosoya, Ken-Ichi
AU  - Hosoya KI
AD  - Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, 
      Toyama 930-0194, Japan.
FAU - Tamai, Ikumi
AU  - Tamai I
AD  - Faculty of Pharmaceutical Sciences, Institute of Medical, Pharmaceutical and 
      Health Sciences, Kanazawa University, Kanazawa, Ishikawa 920-1192, Japan.
FAU - Nakashima, Emi
AU  - Nakashima E
AD  - Faculty of Pharmacy, Keio University, Minato-ku, Tokyo 105-8512, Japan.
FAU - Tomi, Masatoshi
AU  - Tomi M
AD  - Faculty of Pharmacy, Keio University, Minato-ku, Tokyo 105-8512, Japan. 
      Electronic address: tomi-ms@pha.keio.ac.jp.
LA  - eng
PT  - Journal Article
DEP - 20200427
PL  - United States
TA  - iScience
JT  - iScience
JID - 101724038
PMC - PMC7225742
OTO - NOTNLM
OT  - Endocrinology
OT  - Molecular Biology
COIS- Declaration of Interests The authors declare no conflict of interest.
EDAT- 2020/05/15 06:00
MHDA- 2020/05/15 06:01
PMCR- 2020/04/27
CRDT- 2020/05/15 06:00
PHST- 2020/01/15 00:00 [received]
PHST- 2020/03/22 00:00 [revised]
PHST- 2020/04/21 00:00 [accepted]
PHST- 2020/05/15 06:00 [pubmed]
PHST- 2020/05/15 06:01 [medline]
PHST- 2020/05/15 06:00 [entrez]
PHST- 2020/04/27 00:00 [pmc-release]
AID - S2589-0042(20)30283-2 [pii]
AID - 101098 [pii]
AID - 10.1016/j.isci.2020.101098 [doi]
PST - ppublish
SO  - iScience. 2020 May 22;23(5):101098. doi: 10.1016/j.isci.2020.101098. Epub 2020 
      Apr 27.