PMID- 32408235
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20210110
IS  - 2210-2612 (Print)
IS  - 2210-2612 (Electronic)
IS  - 2210-2612 (Linking)
VI  - 70
DP  - 2020
TI  - First ever case report of co-occurrence of hobnail variant of papillary thyroid 
      carcinoma and intrathyroid parathyroid adenoma in the same thyroid lobe.
PG  - 40-52
LID - S2210-2612(20)30217-0 [pii]
LID - 10.1016/j.ijscr.2020.04.025 [doi]
AB  - INTRODUCTION: The hobnail variant of papillary thyroid cancer (PTC) is rare. 
      Intrathyroid parathyroid adenoma (ITPA) is also rare. Co-ocurrence of PTC and 
      ITPA in the same thyroid lobe is extremely rare. Likewise, primary 
      hyperparathyroidism with such non-medullary thyroid carcinoma is rare. The 
      specific molecular profile of hobnail PTC (HPTC) is different from the classic, 
      poorly differentiated and anaplastic variants and may contribute to its 
      aggressive behavior. HPTC's genetic profile remains unclear. PRESENTATION OF 
      CASE: A 61-year-old woman presented to our endocrine clinic with generalized 
      aches, bone pain, polyuria, and right neck swelling of a few months' duration. 
      Laboratory findings revealed hypercalcemia and hyperparathyroidism. Ultrasound of 
      the neck showed 4.6 cm complex nodule within the right thyroid lobe. Sestamibi 
      scan suggested parathyroid adenoma in the right thyroid lobe. Fine-needle 
      aspiration (FNA) revealed atypical follicular lesion of undetermined 
      significance. She underwent right lobectomy, which normalized the intraoperative 
      intact parathyroid hormone levels. Final pathology with immunohistochemical 
      stains demonstrated HPTC and IPTA (2 cm each). Next-generation sequencing 
      investigated the mutation spectrum of HPTC and detected BRAFV600E mutation. 
      CONCLUSIONS: A parathyroid adenoma should not exclude the diagnosis of thyroid 
      carcinoma. Thyroid evaluation is needed for patients with primary 
      hyperparathyroidism to prevent missing concurrent thyroid cancers. 
      Cytomorphologic features to distinguish thyroid from parathyroid cells on FNA 
      cytology must be considered. Immunohistochemical stains are important. BRAFV600E 
      is the most common mutation in HPTC. This is possibly the first reported case of 
      HPTC and ITPA co-occurring within the same thyroid lobe. Studies that define 
      other molecular abnormalities may be useful as therapeutic targets.
CI  - Copyright (c) 2020 The Author(s). Published by Elsevier Ltd.. All rights reserved.
FAU - Al-Yahri, Omer
AU  - Al-Yahri O
AD  - Department of General Surgery, Hamad General Hospital, Doha, Qatar.
FAU - Abdelaal, Abdelrahman
AU  - Abdelaal A
AD  - Department of General Surgery, Hamad General Hospital, Doha, Qatar.
FAU - El Ansari, Walid
AU  - El Ansari W
AD  - Department of Surgery, Hamad General Hospital, Doha, Qatar; College of Medicine, 
      Qatar University, Doha, Qatar; School of Health and Education, University of 
      Skovde, Skovde, Sweden. Electronic address: welansari9@gmail.com.
FAU - Farghaly, Hanan
AU  - Farghaly H
AD  - Department of Lab Medicine & Pathology, Hamad General Hospital, Doha, Qatar.
FAU - Murshed, Khaled
AU  - Murshed K
AD  - Department of Lab Medicine & Pathology, Hamad General Hospital, Doha, Qatar.
FAU - Zirie, Mahmoud A
AU  - Zirie MA
AD  - Department of Endocrinology, Hamad General Hospital, Doha, Qatar.
FAU - Al Hassan, Mohamed S
AU  - Al Hassan MS
AD  - Department of General Surgery, Hamad General Hospital, Doha, Qatar.
LA  - eng
PT  - Case Reports
DEP - 20200505
PL  - Netherlands
TA  - Int J Surg Case Rep
JT  - International journal of surgery case reports
JID - 101529872
PMC - PMC7218145
OTO - NOTNLM
OT  - BRAF(V600E) mutation
OT  - Hobnail papillary thyroid carcinoma
OT  - Molecular profile
OT  - Neck mass
OT  - Parathyroid adenoma
EDAT- 2020/05/15 06:00
MHDA- 2020/05/15 06:01
PMCR- 2020/05/05
CRDT- 2020/05/15 06:00
PHST- 2020/02/21 00:00 [received]
PHST- 2020/04/16 00:00 [revised]
PHST- 2020/04/18 00:00 [accepted]
PHST- 2020/05/15 06:00 [pubmed]
PHST- 2020/05/15 06:01 [medline]
PHST- 2020/05/15 06:00 [entrez]
PHST- 2020/05/05 00:00 [pmc-release]
AID - S2210-2612(20)30217-0 [pii]
AID - 10.1016/j.ijscr.2020.04.025 [doi]
PST - ppublish
SO  - Int J Surg Case Rep. 2020;70:40-52. doi: 10.1016/j.ijscr.2020.04.025. Epub 2020 
      May 5.