PMID- 32410132
OWN - NLM
STAT- MEDLINE
DCOM- 20210913
LR  - 20210913
IS  - 1936-0568 (Electronic)
IS  - 1936-055X (Print)
IS  - 1936-055X (Linking)
VI  - 14
IP  - 4
DP  - 2020 Dec
TI  - Well-Differentiated/Dedifferentiated Liposarcoma Arising in the Upper 
      Aerodigestive Tract: 8 Cases Mimicking Non-adipocytic Lesions.
PG  - 974-981
LID - 10.1007/s12105-020-01171-x [doi]
AB  - Well-differentiated (WDL) and dedifferentiated liposarcomas (DL) of the pharynx, 
      larynx and oral cavity are rare, often mimicking benign lipomatous neoplasms or 
      non-lipogenic mesenchymal tumors. Cases of WDL/DL arising in the upper 
      aerodigestive tract, exclusive of the cervical esophagus, were reviewed. 
      Morphologic features, ancillary studies, including fluorescence in situ 
      hybridization (FISH) studies for CPM/MDM2, and clinical data was catalogued. 
      Eight WDL/DL (4 WDL, 4 DL); were identified in patients ranging from 32 to 77 
      years (median 52.5 years; 6 males, 2 females) with sites of origin including 
      hypopharynx (5 cases), larynx (2 cases) and oral cavity (1 case). Six of the 8 
      cases were received for expert consultation, and the remaining 2 cases were 
      initially misdiagnosed as benign lymphangiomatous or fibroepithelial polyps. 
      Morphologically, 4 tumors had areas mimicking various non-lipomatous soft tissue 
      tumors including nodular fasciitis, mammary-type myofibroblastoma, low-grade 
      myofibroblastic sarcoma and undifferentiated pleomorphic sarcoma, 2 cases 
      simulated benign hypopharyngeal polyps, and 1 lesion was notable for a dense 
      lymphoplasmacytic infiltrate suggestive of hematolymphoid neoplasm or 
      IgG4-related sclerosing disease. FISH showed amplification of CPM/MDM2 (8/8 
      cases). All cases (4/4) with longer than 1-year of follow-up recurred (45-118 
      months) with 1 tumor showing progression to DL. WDL/DL presenting in the upper 
      aerodigestive tract are rare and diagnostically challenging. Awareness of the 
      morphologic spectrum of WDL/DL coupled with appropriate use of MDM2 FISH is 
      essential for accurate classification and management, as these tumors appear to 
      have a high risk for local recurrence and eventual dedifferentiation in these 
      anatomical locations.
FAU - Fritchie, Karen
AU  - Fritchie K
AUID- ORCID: 0000-0003-2336-3691
AD  - Anatomic Pathology - Department of Laboratory Medicine and Pathology, Mayo 
      Clinic, 200 First Street, SW, Rochester, MN, 55905, USA. Fritchie.Karen@mayo.edu.
FAU - Ghosh, Toshi
AU  - Ghosh T
AD  - Anatomic Pathology - Department of Laboratory Medicine and Pathology, Mayo 
      Clinic, 200 First Street, SW, Rochester, MN, 55905, USA.
FAU - Graham, Rondell P
AU  - Graham RP
AD  - Anatomic Pathology - Department of Laboratory Medicine and Pathology, Mayo 
      Clinic, 200 First Street, SW, Rochester, MN, 55905, USA.
FAU - Roden, Anja C
AU  - Roden AC
AD  - Anatomic Pathology - Department of Laboratory Medicine and Pathology, Mayo 
      Clinic, 200 First Street, SW, Rochester, MN, 55905, USA.
FAU - Schembri-Wismayer, David
AU  - Schembri-Wismayer D
AD  - Anatomic Pathology - Department of Laboratory Medicine and Pathology, Mayo 
      Clinic, 200 First Street, SW, Rochester, MN, 55905, USA.
FAU - Folpe, Andrew
AU  - Folpe A
AD  - Anatomic Pathology - Department of Laboratory Medicine and Pathology, Mayo 
      Clinic, 200 First Street, SW, Rochester, MN, 55905, USA.
FAU - Rivera, Michael
AU  - Rivera M
AD  - Anatomic Pathology - Department of Laboratory Medicine and Pathology, Mayo 
      Clinic, 200 First Street, SW, Rochester, MN, 55905, USA.
LA  - eng
PT  - Journal Article
DEP - 20200514
PL  - United States
TA  - Head Neck Pathol
JT  - Head and neck pathology
JID - 101304010
SB  - IM
MH  - Adult
MH  - Aged
MH  - Diagnosis, Differential
MH  - Female
MH  - Humans
MH  - Laryngeal Neoplasms/diagnosis/*pathology
MH  - Liposarcoma/diagnosis/*pathology
MH  - Male
MH  - Middle Aged
MH  - Mouth Neoplasms/diagnosis/*pathology
MH  - Pharyngeal Neoplasms/diagnosis/*pathology
PMC - PMC7669978
OTO - NOTNLM
OT  - Hypopharynx
OT  - Larynx
OT  - Liposarcoma
OT  - MDM2
OT  - Upper aerodigestive tract
COIS- The authors declare that they have no conflict of interest.
EDAT- 2020/05/16 06:00
MHDA- 2021/09/14 06:00
PMCR- 2021/05/14
CRDT- 2020/05/16 06:00
PHST- 2020/03/25 00:00 [received]
PHST- 2020/05/03 00:00 [accepted]
PHST- 2020/04/28 00:00 [revised]
PHST- 2020/05/16 06:00 [pubmed]
PHST- 2021/09/14 06:00 [medline]
PHST- 2020/05/16 06:00 [entrez]
PHST- 2021/05/14 00:00 [pmc-release]
AID - 10.1007/s12105-020-01171-x [pii]
AID - 1171 [pii]
AID - 10.1007/s12105-020-01171-x [doi]
PST - ppublish
SO  - Head Neck Pathol. 2020 Dec;14(4):974-981. doi: 10.1007/s12105-020-01171-x. Epub 
      2020 May 14.