PMID- 32410320
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200928
IS  - 1386-6346 (Print)
IS  - 1386-6346 (Linking)
VI  - 50
IP  - 8
DP  - 2020 Aug
TI  - Allele HLA-DQB1*06 reduces fibrosis score in patients with non-alcoholic fatty 
      liver disease.
PG  - 947-954
LID - 10.1111/hepr.13525 [doi]
AB  - AIM: Human leukocyte antigen (HLA) regions were highlighted as important genetic 
      markers for various liver diseases by hepatology-related genome-wide association 
      studies. Replication studies in non-alcoholic fatty liver disease (NAFLD) are 
      limited and none has investigated the association of HLA alleles with 
      non-alcoholic steatohepatitis (NASH) and other histological characteristics. In 
      the current study, we examined the association of HLA-DQA1 and HLA-DQB1 alleles 
      with NAFLD spectrum and its histological characteristics. METHODS: Consecutive 
      biopsy-proven NAFLD patients (n = 191) and healthy controls (n = 188) were 
      enrolled and genotyped for HLA-DQA1 and HLA-DQB1 alleles using the 
      sequence-specific oligonucleotide-polymerase chain reaction method. RESULTS: No 
      association was found between the HLA alleles and NAFLD or NASH in a case-control 
      setting. Nevertheless, among NAFLD patients, the frequency of HLA-DQB1*06 allele 
      was significantly the lowest in NASH with significant fibrosis (10.4%) and 
      approximately similar for NASH without significant fibrosis (22.9%) and NAFL 
      (22.5%) (P = 0.004). It is noteworthy that the association remains significant 
      after correction for multiple comparisons (P(c)  = 0.04). Multivariate analysis 
      revealed that HLA-DQB1*06 allele is also associated with fibrosis score 
      (P = 0.001); the result remains significant after correction for multiple 
      comparisons. CONCLUSION: These findings suggest that HLA-DQB1*06 is associated 
      with lower fibrosis score in NAFLD patients.
CI  - (c) 2020 The Japan Society of Hepatology.
FAU - Tan, Hwa-Li
AU  - Tan HL
AUID- ORCID: 0000-0001-9183-6222
AD  - Department of Pharmacology, Faculty of Medicine, University of Malaya, Kuala 
      Lumpur, Malaysia.
FAU - Zain, Shamsul Mohd
AU  - Zain SM
AUID- ORCID: 0000-0002-3441-6659
AD  - Department of Pharmacology, Faculty of Medicine, University of Malaya, Kuala 
      Lumpur, Malaysia.
FAU - Eng, Hooi-Sian
AU  - Eng HS
AUID- ORCID: 0000-0002-4681-0848
AD  - Nephrology and Transplantation Unit, Department of Medicine, Faculty of Medicine, 
      University of Malaya, Kuala Lumpur, Malaysia.
FAU - Mohamed, Zahurin
AU  - Mohamed Z
AUID- ORCID: 0000-0002-4396-0517
AD  - Department of Pharmacology, Faculty of Medicine, University of Malaya, Kuala 
      Lumpur, Malaysia.
FAU - Mahadeva, Sanjiv
AU  - Mahadeva S
AUID- ORCID: 0000-0001-5824-0590
AD  - Department of Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, 
      Malaysia.
FAU - Chan, Wah-Kheong
AU  - Chan WK
AUID- ORCID: 0000-0002-9105-5837
AD  - Department of Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, 
      Malaysia.
FAU - Lau, Peng-Choong
AU  - Lau PC
AUID- ORCID: 0000-0003-2702-0282
AD  - Department of Surgery, Faculty of Medicine, University of Malaya, Kuala Lumpur, 
      Malaysia.
FAU - Basu, Roma Choudhury
AU  - Basu RC
AUID- ORCID: 0000-0001-5125-4324
AD  - Clinical Investigation Centre, University Malaya Medical Centre, Kuala Lumpur, 
      Malaysia.
FAU - Mohamed, Rosmawati
AU  - Mohamed R
AUID- ORCID: 0000-0001-7595-5045
AD  - Department of Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, 
      Malaysia.
LA  - eng
GR  - BK077-2016 grant/Universiti Malaya/
PT  - Journal Article
DEP - 20200608
PL  - Netherlands
TA  - Hepatol Res
JT  - Hepatology research : the official journal of the Japan Society of Hepatology
JID - 9711801
OTO - NOTNLM
OT  - HLA-DQ
OT  - NAFLD
OT  - NASH
OT  - fatty liver
OT  - fibrosis
OT  - human leukocyte antigen
EDAT- 2020/05/16 06:00
MHDA- 2020/05/16 06:01
CRDT- 2020/05/16 06:00
PHST- 2019/08/08 00:00 [received]
PHST- 2020/05/08 00:00 [revised]
PHST- 2020/05/09 00:00 [accepted]
PHST- 2020/05/16 06:00 [pubmed]
PHST- 2020/05/16 06:01 [medline]
PHST- 2020/05/16 06:00 [entrez]
AID - 10.1111/hepr.13525 [doi]
PST - ppublish
SO  - Hepatol Res. 2020 Aug;50(8):947-954. doi: 10.1111/hepr.13525. Epub 2020 Jun 8.