PMID- 32410550
OWN - NLM
STAT- MEDLINE
DCOM- 20210504
LR  - 20210504
IS  - 1875-533X (Electronic)
IS  - 0929-8673 (Linking)
VI  - 28
IP  - 8
DP  - 2021
TI  - Curcumin: A Dietary Phytochemical for Targeting the Phenotype and Function of 
      Dendritic Cells.
PG  - 1549-1564
LID - 10.2174/0929867327666200515101228 [doi]
AB  - Dendritic cells (DCs) are the most powerful antigen-presenting cells which link 
      the innate and adaptive immune responses. Depending on the context, DCs initiate 
      the immune responses or contribute to immune tolerance. Any disturbance in their 
      phenotypes and functions may initiate inflammatory or autoimmune diseases. Hence, 
      dysregulated DCs are the most attractive pharmacological target for the 
      development of new therapies aiming at reducing their immunogenicity and at 
      enhancing their tolerogenicity. Curcumin is the polyphenolic phytochemical 
      component of the spice turmeric with a wide range of pharmacological activities. 
      It acts in several ways as a modulator of DCs and converts them into tolerogenic 
      DCs. Tolerogenic DCs possess anti-inflammatory and immunomodulatory activities 
      that regulate the immune responses in health and disease. Curcumin by blocking 
      maturation markers, cytokines and chemokines expression, and disrupting the 
      antigen-presenting machinery of DCs render them non- or hypo-responsive to 
      immunostimulants. It also reduces the expression of co-stimulatory and adhesion 
      molecules on DCs and prevents them from both migration and antigen presentation 
      but enhances their endocytosis capacity. Hence, curcumin causes DCs-inducing 
      regulatory T cells and dampens CD4+ T helper 1 (Th1), Th2, and Th17 polarization. 
      Inhibition of transcription factors such as NF-kappaB, AP-1, MAPKs (p38, JNK, ERK) 
      and other intracellular signaling molecules such as JAK/STAT/SOCS provide a 
      plausible explanation for most of these observations. In this review, we 
      summarize the potential effects of curcumin on the phenotypes and functions of 
      DCs as the key players in orchestration, stimulation, and modulation of the 
      immune responses.
CI  - Copyright(c) Bentham Science Publishers; For any queries, please email at 
      epub@benthamscience.net.
FAU - Rahimi, Kaveh
AU  - Rahimi K
AD  - Cellular and Molecular Research Center, Research Institute for Health 
      Development, Kurdistan University of Medical Sciences, Sanandaj, Iran.
FAU - Hassanzadeh, Kambiz
AU  - Hassanzadeh K
AD  - Cellular and Molecular Research Center, Research Institute for Health 
      Development, Kurdistan University of Medical Sciences, Sanandaj, Iran.
FAU - Khanbabaei, Hashem
AU  - Khanbabaei H
AD  - Medical Physics Department, Faculty of Medicine, Ahvaz Jundishapur University of 
      Medical Sciences, Ahvaz, Iran.
FAU - Haftcheshmeh, Saeed M
AU  - Haftcheshmeh SM
AD  - Department of Medical Immunology, Faculty of Medicine, Mashhad University of 
      Medical Sciences, Mashhad 91766-99199, Iran.
FAU - Ahmadi, Abbas
AU  - Ahmadi A
AD  - Cellular and Molecular Research Center, Research Institute for Health 
      Development, Kurdistan University of Medical Sciences, Sanandaj, Iran.
FAU - Izadpanah, Esmael
AU  - Izadpanah E
AD  - Cellular and Molecular Research Center, Research Institute for Health 
      Development, Kurdistan University of Medical Sciences, Sanandaj, Iran.
FAU - Mohammadi, Asadollah
AU  - Mohammadi A
AD  - Cellular and Molecular Research Center, Research Institute for Health 
      Development, Kurdistan University of Medical Sciences, Sanandaj, Iran.
FAU - Sahebkar, Amirhossein
AU  - Sahebkar A
AD  - Halal Research Center of IRI, FDA, Tehran, Iran.
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United Arab Emirates
TA  - Curr Med Chem
JT  - Current medicinal chemistry
JID - 9440157
RN  - 0 (Phytochemicals)
RN  - IT942ZTH98 (Curcumin)
SB  - IM
MH  - *Curcumin/pharmacology
MH  - Dendritic Cells
MH  - Immune Tolerance
MH  - Phenotype
MH  - Phytochemicals
OTO - NOTNLM
OT  - Curcumin
OT  - autoimmunity
OT  - dendritic cells
OT  - diatery phytochemical
OT  - immunomodulator
OT  - inflammation
EDAT- 2020/05/16 06:00
MHDA- 2021/05/05 06:00
CRDT- 2020/05/16 06:00
PHST- 2019/11/13 00:00 [received]
PHST- 2020/04/05 00:00 [revised]
PHST- 2020/04/19 00:00 [accepted]
PHST- 2020/05/16 06:00 [pubmed]
PHST- 2021/05/05 06:00 [medline]
PHST- 2020/05/16 06:00 [entrez]
AID - CMC-EPUB-106647 [pii]
AID - 10.2174/0929867327666200515101228 [doi]
PST - ppublish
SO  - Curr Med Chem. 2021;28(8):1549-1564. doi: 10.2174/0929867327666200515101228.