PMID- 32411441
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220414
IS  - 2090-8016 (Print)
IS  - 2090-0597 (Electronic)
IS  - 2090-0597 (Linking)
VI  - 2020
DP  - 2020
TI  - Combination of Left Ventricular End-Diastolic Diameter and QRS Duration Strongly 
      Predicts Good Response to and Prognosis of Cardiac Resynchronization Therapy.
PG  - 1257578
LID - 10.1155/2020/1257578 [doi]
LID - 1257578
AB  - BACKGROUND: Approximately 20-40% of recipients of cardiac resynchronization 
      therapy (CRT) do not respond to it based on the current patient selection 
      criteria. The purpose of this study was to identify baseline parameters that can 
      predict CRT response and to evaluate the effect of those predictive parameters on 
      long-term prognosis. METHODS: This was a retrospective, nonrandomized, 
      noncontrolled cohort study. Patients who received CRT in our centre were divided 
      into responders and nonresponders by the definition of CRT response (an increase 
      in left ventricular ejection fraction (LVEF) of >/=5% and improvement of >/=1 New 
      York Heart Association (NYHA) class from baseline to the 6-month follow-up). 
      RESULTS: Of the 101 patients, 68 were responders and 33 were nonresponders. Left 
      ventricular end-diastolic diameter (LVEDD; OR: 0.88, 95% CI: 0.81-0.95, P=0.001) 
      and QRS duration (OR: 1.07, 95% CI: 1.04-1.10, P < 0.001) were independent 
      predictors of CRT response. The combination of LVEDD and QRS duration was more 
      valuable for predicting CRT response (AUC 0.836; 95% CI: 0.76-0.91; P < 0.001). 
      Moreover, the combination of LVEDD </= 71 mm and QRS duration >/= 170 ms had a low 
      incidence of all-cause mortality, HF hospitalisation, and the composite endpoint. 
      In addition, baseline LVEDD had a positive correlation with QRS duration 
      (R=0.199, P=0.046). Responders to CRT had better LV reverse remodeling. 
      CONCLUSION: The combination of LVEDD and QRS duration provided more robust 
      prediction of CRT response. Moreover, the combination of LVEDD </= 71 mm and QRS 
      duration >/= 170 ms was associated with a low incidence of all-cause mortality, HF 
      hospitalisation, and the composite endpoint. Our results may be useful to provide 
      individualized patient selection for CRT.
CI  - Copyright (c) 2020 Zhinian Guo et al.
FAU - Guo, Zhinian
AU  - Guo Z
AD  - Institute of Cardiovascular Diseases, Xinqiao Hospital, Army Medical University 
      (Third Military Medical University), 183 Xinqiao Street, Chongqing 400037, China.
FAU - Liu, Xiaoyan
AU  - Liu X
AD  - Institute of Cardiovascular Diseases, Xinqiao Hospital, Army Medical University 
      (Third Military Medical University), 183 Xinqiao Street, Chongqing 400037, China.
FAU - Cheng, Xiaofeng
AU  - Cheng X
AD  - Institute of Cardiovascular Diseases, Xinqiao Hospital, Army Medical University 
      (Third Military Medical University), 183 Xinqiao Street, Chongqing 400037, China.
FAU - Liu, Chuan
AU  - Liu C
AD  - Institute of Cardiovascular Diseases, Xinqiao Hospital, Army Medical University 
      (Third Military Medical University), 183 Xinqiao Street, Chongqing 400037, China.
FAU - Li, Ping
AU  - Li P
AD  - Institute of Cardiovascular Diseases, Xinqiao Hospital, Army Medical University 
      (Third Military Medical University), 183 Xinqiao Street, Chongqing 400037, China.
FAU - He, Yongming
AU  - He Y
AD  - Institute of Cardiovascular Diseases, Xinqiao Hospital, Army Medical University 
      (Third Military Medical University), 183 Xinqiao Street, Chongqing 400037, China.
FAU - Rao, Rongsheng
AU  - Rao R
AD  - Institute of Cardiovascular Diseases, Xinqiao Hospital, Army Medical University 
      (Third Military Medical University), 183 Xinqiao Street, Chongqing 400037, China.
FAU - Li, Chun
AU  - Li C
AD  - Institute of Cardiovascular Diseases, Xinqiao Hospital, Army Medical University 
      (Third Military Medical University), 183 Xinqiao Street, Chongqing 400037, China.
FAU - Chen, Yunlong
AU  - Chen Y
AD  - Institute of Cardiovascular Diseases, Xinqiao Hospital, Army Medical University 
      (Third Military Medical University), 183 Xinqiao Street, Chongqing 400037, China.
FAU - Zhang, Yong
AU  - Zhang Y
AD  - Institute of Cardiovascular Diseases, Xinqiao Hospital, Army Medical University 
      (Third Military Medical University), 183 Xinqiao Street, Chongqing 400037, China.
FAU - Luo, Xiaoyu
AU  - Luo X
AD  - Institute of Cardiovascular Diseases, Xinqiao Hospital, Army Medical University 
      (Third Military Medical University), 183 Xinqiao Street, Chongqing 400037, China.
FAU - Wang, Jiang
AU  - Wang J
AUID- ORCID: 0000-0002-2018-4228
AD  - Institute of Cardiovascular Diseases, Xinqiao Hospital, Army Medical University 
      (Third Military Medical University), 183 Xinqiao Street, Chongqing 400037, China.
LA  - eng
PT  - Journal Article
DEP - 20200117
PL  - United States
TA  - Cardiol Res Pract
JT  - Cardiology research and practice
JID - 101516542
PMC - PMC7201746
COIS- The authors declare that they have no conflicts of interest.
EDAT- 2020/05/16 06:00
MHDA- 2020/05/16 06:01
PMCR- 2020/01/17
CRDT- 2020/05/16 06:00
PHST- 2019/10/10 00:00 [received]
PHST- 2019/12/26 00:00 [accepted]
PHST- 2020/05/16 06:00 [entrez]
PHST- 2020/05/16 06:00 [pubmed]
PHST- 2020/05/16 06:01 [medline]
PHST- 2020/01/17 00:00 [pmc-release]
AID - 10.1155/2020/1257578 [doi]
PST - epublish
SO  - Cardiol Res Pract. 2020 Jan 17;2020:1257578. doi: 10.1155/2020/1257578. 
      eCollection 2020.