PMID- 32413009
OWN - NLM
STAT- MEDLINE
DCOM- 20210409
LR  - 20221005
IS  - 1538-9235 (Electronic)
IS  - 1040-5488 (Print)
IS  - 1040-5488 (Linking)
VI  - 97
IP  - 5
DP  - 2020 May
TI  - Validation of an Automated Early Treatment Diabetic Retinopathy Study 
      Low-contrast Letter Acuity Test.
PG  - 370-376
LID - 10.1097/OPX.0000000000001506 [doi]
AB  - SIGNIFICANCE: Automated low-contrast letter acuity (LCLA) has several advantages: 
      consistent luminance, reduced chance of individuals memorizing test letters, and 
      convenient and accurate visual acuity reporting functions. Although automated 
      LCLA might report slightly worse acuity than Sloan LCLA chart, considering its 
      advantages, it may be a viable alternative to Sloan LCLA chart in clinical 
      practice and research. PURPOSE: The purpose of this study was to determine the 
      repeatability of an automated LCLA measurement and its agreement with the Sloan 
      LCLA chart test in normal participants and reduced-vision participants. METHODS: 
      Adult participants (n = 49) were measured with both automated Early Treatment 
      Diabetic Retinopathy Study and Sloan LCLA tests, including normal and 
      reduced-vision groups. Low-contrast letter acuity at two contrast levels (2.5 and 
      10%) was measured at 3 m in a random sequence with both LCLA tests. To test 
      repeatability, participants were retested 1 week later. Repeatability of the two 
      tests between two visits and agreement between automated and Sloan LCLA tests 
      were evaluated using 95% limits of agreement. RESULTS: In terms of the 95% limits 
      of agreement, the repeatability of both tests was as follows: automated LCLA at 
      2.5%, +/-0.26; automated LCLA at 10%, +/-0.22; Sloan LCLA at 2.5%, +/-0.23, and Sloan 
      LCLA at 10%, +/-0.16. The agreement of the two tests was as follows: +/-0.19 at 2.5% 
      and +/-0.24 at 10%. The automated LCLA at 2.5 and 10% levels was generally reported 
      one-half to one logMAR line lower than Sloan LCLA (mean differences, -0.04 at 
      2.5% and -0.13 at 10%; paired t test, P < .05). CONCLUSIONS: The automated LCLA 
      test shows fairly good test-retest repeatability at both 2.5 and 10% contrast 
      levels. The agreement between the automated and the Sloan low-contrast letter 
      acuity tests was comparable with test-retest agreement. Although the automated 
      LCLA test reports slightly worse acuity than the Sloan LCLA test, it could be an 
      appropriate alternative to the Sloan LCLA test.
FAU - Pang, Yi
AU  - Pang Y
FAU - Sparschu, Lauren
AU  - Sparschu L
AD  - Illinois College of Optometry, Chicago, Illinois.
FAU - Nylin, Elyse
AU  - Nylin E
AD  - Illinois College of Optometry, Chicago, Illinois.
FAU - Wang, Jingyun
AU  - Wang J
AD  - Salus University Pennsylvania College of Optometry, Elkins Park, Pennsylvania.
LA  - eng
GR  - R21 EY026664/EY/NEI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Validation Study
PL  - United States
TA  - Optom Vis Sci
JT  - Optometry and vision science : official publication of the American Academy of 
      Optometry
JID - 8904931
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Contrast Sensitivity/*physiology
MH  - Diabetic Retinopathy/physiopathology
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Probability
MH  - Reproducibility of Results
MH  - Vision Disorders/*physiopathology
MH  - Vision Tests/*instrumentation
MH  - Visual Acuity/*physiology
MH  - Young Adult
PMC - PMC7370921
MID - NIHMS1578839
EDAT- 2020/05/16 06:00
MHDA- 2021/04/10 06:00
PMCR- 2021/05/01
CRDT- 2020/05/16 06:00
PHST- 2020/05/16 06:00 [entrez]
PHST- 2020/05/16 06:00 [pubmed]
PHST- 2021/04/10 06:00 [medline]
PHST- 2021/05/01 00:00 [pmc-release]
AID - 00006324-202005000-00009 [pii]
AID - 10.1097/OPX.0000000000001506 [doi]
PST - ppublish
SO  - Optom Vis Sci. 2020 May;97(5):370-376. doi: 10.1097/OPX.0000000000001506.