PMID- 32413788
OWN - NLM
STAT- MEDLINE
DCOM- 20200818
LR  - 20200818
IS  - 1872-9142 (Electronic)
IS  - 0161-5890 (Linking)
VI  - 123
DP  - 2020 Jul
TI  - The quest for faithful in vitro models of human dendritic cells types.
PG  - 40-59
LID - S0161-5890(19)30917-4 [pii]
LID - 10.1016/j.molimm.2020.04.018 [doi]
AB  - Dendritic cells (DCs) are mononuclear phagocytes that are specialized in the 
      induction and functional polarization of effector lymphocytes, thus orchestrating 
      immune defenses against infections and cancer. The population of DC encompasses 
      distinct cell types that vary in their efficacy for complementary functions and 
      are thus likely involved in defending the body against different threats. 
      Plasmacytoid DCs specialize in the production of high levels of the antiviral 
      cytokines type I interferons. Type 1 conventional DCs (cDC1s) excel in the 
      activation of cytotoxic CD8(+) T cells (CTLs) which are critical for defense 
      against cancer and infections by intracellular pathogens. Type 2 conventional DCs 
      (cDC2s) prime helper CD4(+) T cells for the production of type 2 cytokines 
      underpinning immune defenses against worms or of IL-17 promoting control of 
      infections by extracellular bacteria or fungi. Hence, clinically manipulating the 
      development and functions of DC types could have a major impact for improving 
      treatments against many diseases. However, the rarity and fragility of human DC 
      types is impeding advancement towards this goal. To overcome this roadblock, 
      major efforts are ongoing to generate in vitro large numbers of distinct human DC 
      types. We review here the current state of this research field, emphasizing 
      recent breakthrough and proposing future priorities. We also pinpoint the 
      necessity to develop a consensus nomenclature and rigorous methodologies to 
      ensure proper identification and characterization of human DC types. Finally, we 
      elaborate on how faithful in vitro models of human DC types can accelerate our 
      understanding of the biology of these cells and the engineering of next 
      generation vaccines or immunotherapies against viral infections or cancer.
CI  - Copyright (c) 2020 Elsevier Ltd. All rights reserved.
FAU - Luo, Xin-Long
AU  - Luo XL
AD  - Aix Marseille Univ, CNRS, INSERM, CIML, Centre d'Immunologie de Marseille-Luminy, 
      Turing Center for Living Systems, Marseille, France.
FAU - Dalod, Marc
AU  - Dalod M
AD  - Aix Marseille Univ, CNRS, INSERM, CIML, Centre d'Immunologie de Marseille-Luminy, 
      Turing Center for Living Systems, Marseille, France. Electronic address: 
      dalod@ciml.univ-mrs.fr.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20200513
PL  - England
TA  - Mol Immunol
JT  - Molecular immunology
JID - 7905289
RN  - 0 (Cytokines)
SB  - IM
MH  - Animals
MH  - Antigen Presentation/physiology
MH  - CD8-Positive T-Lymphocytes/immunology
MH  - Cytokines/metabolism
MH  - Dendritic Cells/*cytology/pathology/*physiology
MH  - Humans
MH  - Lymphocyte Activation
MH  - *Models, Theoretical
MH  - Reproducibility of Results
OTO - NOTNLM
OT  - Cancer
OT  - Hematopoiesis
OT  - Plasmacytoid dendritic cells
OT  - Type 1 conventional dendritic cells
OT  - Viral infection
EDAT- 2020/05/16 06:00
MHDA- 2020/08/19 06:00
CRDT- 2020/05/16 06:00
PHST- 2019/12/19 00:00 [received]
PHST- 2020/04/06 00:00 [revised]
PHST- 2020/04/16 00:00 [accepted]
PHST- 2020/05/16 06:00 [pubmed]
PHST- 2020/08/19 06:00 [medline]
PHST- 2020/05/16 06:00 [entrez]
AID - S0161-5890(19)30917-4 [pii]
AID - 10.1016/j.molimm.2020.04.018 [doi]
PST - ppublish
SO  - Mol Immunol. 2020 Jul;123:40-59. doi: 10.1016/j.molimm.2020.04.018. Epub 2020 May 
      13.