PMID- 32415898
OWN - NLM
STAT- MEDLINE
DCOM- 20210728
LR  - 20210728
IS  - 1443-1661 (Electronic)
IS  - 0915-5635 (Linking)
VI  - 33
IP  - 3
DP  - 2021 Mar
TI  - Endoscopic treatment of proton pump inhibitor-refractory gastroesophageal reflux 
      disease with anti-reflux mucosectomy: Experience of 109 cases.
PG  - 347-354
LID - 10.1111/den.13727 [doi]
AB  - OBJECTIVES: Some patients with gastroesophageal reflux disease (GERD) are 
      refractory to proton pump inhibitor (PPI) therapy. Anti-reflux mucosectomy (ARMS) 
      is a minimally invasive endoscopic procedure for treatment of GERD. In this 
      study, we retrospectively evaluated the outcomes of ARMS performed in patients 
      with PPI-refractory GERD at our institution. METHODS: A total of 109 patients 
      with PPI-refractory GERD who underwent ARMS were retrospectively reviewed. Pre- 
      and post-ARMS questionnaire scores, acid exposure time (AET), DeMeester score, 
      proximal extent, and PPI discontinuation rate were compared. RESULTS: There was a 
      significant improvement in the symptom score (P < 0.01) and 40-50% of patients 
      were able to discontinue PPI after ARMS. In patients who were followed up for 
      3 years, sustained improvement in subjective symptoms was observed. AET and 
      DeMeester score significantly improved after ARMS (P < 0.01); however, there was 
      no significant improvement in proximal extent (P = 0.0846). CONCLUSIONS: 
      Anti-reflux mucosectomy is an effective minimally invasive therapy for patients 
      with PPI-refractory GERD. The therapeutic efficacy is attributable to suppression 
      of acid backflow due to contraction of the scar tissue in cardia.
CI  - (c) 2020 Japan Gastroenterological Endoscopy Society.
FAU - Sumi, Kazuya
AU  - Sumi K
AUID- ORCID: 0000-0002-5484-8504
AD  - Digestive Diseases Center, Showa University Koto-Toyosu Hospital, Tokyo, Japan.
FAU - Inoue, Haruhiro
AU  - Inoue H
AD  - Digestive Diseases Center, Showa University Koto-Toyosu Hospital, Tokyo, Japan.
FAU - Kobayashi, Yasutoshi
AU  - Kobayashi Y
AD  - Digestive Diseases Center, Showa University Koto-Toyosu Hospital, Tokyo, Japan.
FAU - Iwaya, Yugo
AU  - Iwaya Y
AUID- ORCID: 0000-0002-2269-0132
AD  - Digestive Diseases Center, Showa University Koto-Toyosu Hospital, Tokyo, Japan.
FAU - Abad, Mary Raina Angeli
AU  - Abad MRA
AUID- ORCID: 0000-0002-5860-9164
AD  - Digestive Diseases Center, Showa University Koto-Toyosu Hospital, Tokyo, Japan.
FAU - Fujiyoshi, Yusuke
AU  - Fujiyoshi Y
AUID- ORCID: 0000-0002-5893-6552
AD  - Digestive Diseases Center, Showa University Koto-Toyosu Hospital, Tokyo, Japan.
FAU - Shimamura, Yuto
AU  - Shimamura Y
AUID- ORCID: 0000-0003-4107-9264
AD  - Digestive Diseases Center, Showa University Koto-Toyosu Hospital, Tokyo, Japan.
FAU - Ikeda, Haruo
AU  - Ikeda H
AD  - Digestive Diseases Center, Showa University Koto-Toyosu Hospital, Tokyo, Japan.
FAU - Onimaru, Manabu
AU  - Onimaru M
AD  - Digestive Diseases Center, Showa University Koto-Toyosu Hospital, Tokyo, Japan.
LA  - eng
PT  - Journal Article
DEP - 20200811
PL  - Australia
TA  - Dig Endosc
JT  - Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy 
      Society
JID - 9101419
RN  - 0 (Proton Pump Inhibitors)
SB  - IM
MH  - Cardia
MH  - *Gastroesophageal Reflux/drug therapy/surgery
MH  - Humans
MH  - *Proton Pump Inhibitors/therapeutic use
MH  - Retrospective Studies
MH  - Treatment Outcome
OTO - NOTNLM
OT  - anti-reflux mucosectomy
OT  - endoscopic mucosal resection
OT  - gastroesophageal reflux disease
OT  - proton pump inhibitor
EDAT- 2020/05/18 06:00
MHDA- 2021/07/29 06:00
CRDT- 2020/05/17 06:00
PHST- 2020/02/18 00:00 [received]
PHST- 2020/05/11 00:00 [revised]
PHST- 2020/05/11 00:00 [accepted]
PHST- 2020/05/18 06:00 [pubmed]
PHST- 2021/07/29 06:00 [medline]
PHST- 2020/05/17 06:00 [entrez]
AID - 10.1111/den.13727 [doi]
PST - ppublish
SO  - Dig Endosc. 2021 Mar;33(3):347-354. doi: 10.1111/den.13727. Epub 2020 Aug 11.