PMID- 32416676
OWN - NLM
STAT- MEDLINE
DCOM- 20210929
LR  - 20231213
IS  - 1875-5739 (Electronic)
IS  - 1567-2026 (Linking)
VI  - 17
IP  - 3
DP  - 2020
TI  - A Polyphenolic Complex Attenuates Inflammatory Response and Blood- Brain Barrier 
      Disruption.
PG  - 286-293
LID - 10.2174/1567202617666200517105727 [doi]
AB  - BACKGROUND: Cerebral ischemia causes a strong inflammatory response. Neumentix is 
      a dietary supplement containing 14.9% rosmarinic acid and 29.9% total phenolic 
      content, which has been proved to be beneficial against inflammatory response. 
      Therefore, Neumentix's effect on anti-inflammatory and blood brain barrier (BBB) 
      disruption in transient middle cerebral artery occlusion (tMCAO) model mice is 
      investigated in this study. METHODS: After the pretreatment of vehicle or 
      Neumentix 134 mg/kg/d, intraperitoneal injection (i.p.) (containing rosmarinic 
      acid 20 mg/kg/d) for 14 days, mice were subjected to tMCAO for 60 min and kept 
      receiving vehicle or Neumentix daily 5 days afterward. RESULTS: Neumentix 
      treatment ameliorated neurobehavioral impairment in the corner test (5d after 
      tMCAO, **P<0.01), reduced infarct volume (#P<0.05), suppressed expression of 
      ionized calciumbinding adapter molecule-1 (Iba-1), tumor necrosis factor alpha 
      (TNF-alpha) and monocyte chemoattractant protein-1 (MCP-1) (###P<0.001), and improved 
      the integrity of BBB ( section signP<0.05) at 5 days after tMCAO. CONCLUSION: The present 
      study provided an evidence of Neumentix's anti-inflammatory and neuroprotection 
      effect against BBB disruption on experimental tMCAO model mice, suggesting that 
      Neumentix could be a potential therapeutic agent for stroke.
CI  - Copyright(c) Bentham Science Publishers; For any queries, please email at 
      epub@benthamscience.net.
FAU - Bian, Yuting
AU  - Bian Y
AD  - Department of Neurology, Okayama University Graduate School of Medicine, 
      Dentistry and Pharmaceutical Sciences, Okayama, Japan.
FAU - Yamashita, Toru
AU  - Yamashita T
AD  - Department of Neurology, Okayama University Graduate School of Medicine, 
      Dentistry and Pharmaceutical Sciences, Okayama, Japan.
FAU - Taira, Yuki
AU  - Taira Y
AD  - Department of Neurology, Okayama University Graduate School of Medicine, 
      Dentistry and Pharmaceutical Sciences, Okayama, Japan.
FAU - Shang, Jingwei
AU  - Shang J
AD  - Department of Neurology, Okayama University Graduate School of Medicine, 
      Dentistry and Pharmaceutical Sciences, Okayama, Japan.
FAU - Tsunoda, Keiichiro
AU  - Tsunoda K
AD  - Department of Neurology, Okayama University Graduate School of Medicine, 
      Dentistry and Pharmaceutical Sciences, Okayama, Japan.
FAU - Feng, Tian
AU  - Feng T
AD  - Department of Neurology, Okayama University Graduate School of Medicine, 
      Dentistry and Pharmaceutical Sciences, Okayama, Japan.
FAU - Sasaki, Ryo
AU  - Sasaki R
AD  - Department of Neurology, Okayama University Graduate School of Medicine, 
      Dentistry and Pharmaceutical Sciences, Okayama, Japan.
FAU - Liu, Xia
AU  - Liu X
AD  - Department of Neurology, Okayama University Graduate School of Medicine, 
      Dentistry and Pharmaceutical Sciences, Okayama, Japan.
FAU - Shi, Xiaowen
AU  - Shi X
AD  - Department of Neurology, Okayama University Graduate School of Medicine, 
      Dentistry and Pharmaceutical Sciences, Okayama, Japan.
FAU - Tadokoro, Koh
AU  - Tadokoro K
AD  - Department of Neurology, Okayama University Graduate School of Medicine, 
      Dentistry and Pharmaceutical Sciences, Okayama, Japan.
FAU - Nomura, Emi
AU  - Nomura E
AD  - Department of Neurology, Okayama University Graduate School of Medicine, 
      Dentistry and Pharmaceutical Sciences, Okayama, Japan.
FAU - Matsumoto, Namiko
AU  - Matsumoto N
AD  - Department of Neurology, Okayama University Graduate School of Medicine, 
      Dentistry and Pharmaceutical Sciences, Okayama, Japan.
FAU - Osakada, Yusuke
AU  - Osakada Y
AD  - Department of Neurology, Okayama University Graduate School of Medicine, 
      Dentistry and Pharmaceutical Sciences, Okayama, Japan.
FAU - Omote, Yoshio
AU  - Omote Y
AD  - Department of Neurology, Okayama University Graduate School of Medicine, 
      Dentistry and Pharmaceutical Sciences, Okayama, Japan.
FAU - Takemoto, Mami
AU  - Takemoto M
AD  - Department of Neurology, Okayama University Graduate School of Medicine, 
      Dentistry and Pharmaceutical Sciences, Okayama, Japan.
FAU - Hishikawa, Nozomi
AU  - Hishikawa N
AD  - Department of Neurology, Okayama University Graduate School of Medicine, 
      Dentistry and Pharmaceutical Sciences, Okayama, Japan.
FAU - Ohta, Yasuyuki
AU  - Ohta Y
AD  - Department of Neurology, Okayama University Graduate School of Medicine, 
      Dentistry and Pharmaceutical Sciences, Okayama, Japan.
FAU - Abe, Koji
AU  - Abe K
AD  - Department of Neurology, Okayama University Graduate School of Medicine, 
      Dentistry and Pharmaceutical Sciences, Okayama, Japan.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United Arab Emirates
TA  - Curr Neurovasc Res
JT  - Current neurovascular research
JID - 101208439
RN  - 0 (Anti-Inflammatory Agents)
RN  - 0 (Cinnamates)
RN  - 0 (Depsides)
RN  - 0 (Inflammation Mediators)
RN  - 0 (Neuroprotective Agents)
RN  - 0 (Polyphenols)
SB  - IM
MH  - Animals
MH  - Anti-Inflammatory Agents/*administration & dosage
MH  - Blood-Brain Barrier/*drug effects/*metabolism/pathology
MH  - Cinnamates/*administration & dosage
MH  - Depsides/*administration & dosage
MH  - Dietary Supplements
MH  - Infarction, Middle Cerebral Artery/drug therapy/metabolism/pathology
MH  - Inflammation Mediators/antagonists & inhibitors/metabolism
MH  - Male
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Neuroprotective Agents/*administration & dosage
MH  - Polyphenols/*administration & dosage
MH  - Rosmarinic Acid
OTO - NOTNLM
OT  - Ischemic stroke
OT  - anti-inflammation
OT  - blood brain barrier
OT  - middle cerebral artery occlusion
OT  - polyphenolic complex
OT  - rosmarinic acid
EDAT- 2020/05/18 06:00
MHDA- 2021/09/30 06:00
CRDT- 2020/05/18 06:00
PHST- 2020/03/02 00:00 [received]
PHST- 2020/03/09 00:00 [revised]
PHST- 2020/03/13 00:00 [accepted]
PHST- 2020/05/18 06:00 [pubmed]
PHST- 2021/09/30 06:00 [medline]
PHST- 2020/05/18 06:00 [entrez]
AID - CNR-EPUB-106698 [pii]
AID - 10.2174/1567202617666200517105727 [doi]
PST - ppublish
SO  - Curr Neurovasc Res. 2020;17(3):286-293. doi: 10.2174/1567202617666200517105727.