PMID- 32416680
OWN - NLM
STAT- MEDLINE
DCOM- 20211210
LR  - 20211214
IS  - 1875-6220 (Electronic)
IS  - 1570-1638 (Linking)
VI  - 18
IP  - 2
DP  - 2021
TI  - Immunomodulatory Effects of Medicinal Plants used for Vitiligo in Traditional 
      Persian Medicine.
PG  - 160-178
LID - 10.2174/1570163817666200517115438 [doi]
AB  - BACKGROUND: Vitiligo is a hypopigmentation disorder that affects 1% of the 
      world's population. Vitiligo causes white spots on the skin, mucous membranes, or 
      white hair by destroying skin melanocytes. The pathogenesis of vitiligo is 
      unknown but autoimmune, autocytotoxic, and neural mechanisms are suggested. 
      According to the autoimmune theory, in people with vitiligo, immune cells invade 
      and damage melanocytes. T cells are more commonly present in vitiligo patients' 
      skin and remain in the lesion site, which is composed of CD8 and CD4 T cells. 
      Many studies have been conducted on the presence and role of cytokines such as 
      interleukins and interferongamma (IFN-gamma) in the vitiligo process. AIM: This study 
      aimed to introduce herbs effective against vitiligo from the perspective of 
      Persian medicine and to investigate their possible therapeutic mechanisms with 
      the possible effects of herbs on autoimmune mechanisms. METHODS: For this 
      purpose, keywords were used to extract data from Persian medicine textbooks, and 
      then relevant scientific databases, including Google Scholar, PubMed, Web of 
      Science, and Scopus were examined. RESULTS: It was found that Persian medicine 
      scholars used 50 different medicinal plants to treat and reduce the complications 
      of vitiligo, and recent scientific studies have proven immune-regulating 
      properties and reducing the effect of many of them on cytokines. CONCLUSION: 
      According to scientific evidence on immunomodulatory effects, new research into 
      the effects of these plants on vitiligo can lead to the discovery of new drugs 
      and approaches for treating this disease.
CI  - Copyright(c) Bentham Science Publishers; For any queries, please email at 
      epub@benthamscience.net.
FAU - Ebrahimabadi, Mohsen Haghir
AU  - Ebrahimabadi MH
AD  - Department of Traditional Pharmacy, School of Persian Medicine, Tehran University 
      of Medical Sciences, Tehran, Iran.
FAU - Lamardi, Seyede Nargess Sadati
AU  - Lamardi SNS
AD  - Department of Traditional Pharmacy, School of Persian Medicine, Tehran University 
      of Medical Sciences, Tehran, Iran.
FAU - Shirbeigi, Laila
AU  - Shirbeigi L
AD  - Department of Traditional Medicine, School of Persian Medicine, Tehran University 
      of Medical Sciences, Tehran, Iran.
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United Arab Emirates
TA  - Curr Drug Discov Technol
JT  - Current drug discovery technologies
JID - 101157212
RN  - 0 (Immunologic Factors)
SB  - IM
MH  - Drug Discovery
MH  - Humans
MH  - Immunologic Factors/*pharmacology
MH  - Medicine, Persian/*methods
MH  - Phytotherapy/methods
MH  - Plants, Medicinal/*classification
MH  - *Vitiligo/drug therapy/immunology
OTO - NOTNLM
OT  - Herbal medicine
OT  - interferon-gamma (IFN-gamma)
OT  - interleukins
OT  - persian medicine
OT  - tumor necrosis factor alpha (TNF-alpha)
OT  - vitiligo
EDAT- 2020/05/18 06:00
MHDA- 2021/12/15 06:00
CRDT- 2020/05/18 06:00
PHST- 2019/10/23 00:00 [received]
PHST- 2020/02/14 00:00 [revised]
PHST- 2020/03/09 00:00 [accepted]
PHST- 2020/05/18 06:00 [pubmed]
PHST- 2021/12/15 06:00 [medline]
PHST- 2020/05/18 06:00 [entrez]
AID - CDDT-EPUB-106706 [pii]
AID - 10.2174/1570163817666200517115438 [doi]
PST - ppublish
SO  - Curr Drug Discov Technol. 2021;18(2):160-178. doi: 
      10.2174/1570163817666200517115438.