PMID- 32416843
OWN - NLM
STAT- MEDLINE
DCOM- 20210105
LR  - 20240229
IS  - 1525-3171 (Electronic)
IS  - 0032-5791 (Print)
IS  - 0032-5791 (Linking)
VI  - 99
IP  - 1
DP  - 2020 Jan
TI  - Effect of heat stress on mitogen-activated protein kinases in the 
      hypothalamic-pituitary-gonadal axis of developing Wenchang chicks.
PG  - 567-577
LID - S0032-5791(19)57901-9 [pii]
LID - 10.3382/ps/pez499 [doi]
AB  - The regulatory roles of mitogen-activated protein kinase (MAPK) signaling 
      pathways on the hypothalamic-pituitary-gonadal axis (HPG axis) of Wenchang chicks 
      under heat stress (HS) were investigated. Additionally, the crosstalk between 
      these signaling pathways was explored. Immunohistochemical experiments and 
      Western blotting were employed to quantify extracellular regulated protein 
      kinases (ERK), c-Jun N-terminal kinases (JNK), and p38MAPK (P38). In female 
      chicks, hypothalamic ERKs were upregulated in Weeks 1 and 2 in the HS group 
      compared with the control group (CK), while JNK and p38 were downregulated (P < 
      0.05). Pituitary MAPKs were all downregulated in the HS group compared with the 
      CK group in Week 3, but p38 was upregulated in Week 4 (P < 0.01). In the HS 
      group, ovarian MAPKs were all upregulated compared with the CK group during Week 
      5, whereas ERK was downregulated in Week 6 (P < 0.01). In contrast to the 
      patterns of MAPK expression in female chicks in the HS and CK groups, ERK in male 
      chicks showed a completely opposite pattern in Weeks 1, 2, and 5, while p38 and 
      JNK were downregulated in both female and male chicks under HS during Weeks 2 and 
      3. In the HS group, pituitary and testis MAPKs showed a pattern opposite to that 
      observed in female chicks under HS in Week 5; MAPKs were all downregulated (P < 
      0.05). Thus, there are gender differences in the MAPK signaling pathways in the 
      HPG axis in chicks, and these pathways showed plasticity. Early HS can enhance 
      chick growth and development as well as promote developing in the MAPK signaling 
      pathways in the HPG axis. However, after heated brooding was discontinued in 
      chicks, long-term HS obstructed chick development and caused tissue and function 
      injury to the HPG axis.
CI  - Copyright (c) 2019 The Author(s). Published by Elsevier Inc. All rights reserved.
FAU - Li, Q H
AU  - Li QH
AD  - College of Life Science, Hainan Normal University, Haikou 571158, China.
FAU - Yu, Z Q
AU  - Yu ZQ
AD  - College of Life Science, Hainan Normal University, Haikou 571158, China.
FAU - Chen, Z
AU  - Chen Z
AD  - College of Life Science, Hainan Normal University, Haikou 571158, China. 
      Electronic address: zh.chen@hainnu.edu.cn.
LA  - eng
PT  - Journal Article
DEP - 20191230
PL  - England
TA  - Poult Sci
JT  - Poultry science
JID - 0401150
RN  - 0 (Avian Proteins)
RN  - EC 2.7.11.24 (JNK Mitogen-Activated Protein Kinases)
RN  - EC 2.7.11.24 (Mitogen-Activated Protein Kinases)
RN  - EC 2.7.11.24 (p38 Mitogen-Activated Protein Kinases)
SB  - IM
MH  - Animals
MH  - Avian Proteins/*genetics/metabolism
MH  - Chickens/genetics/growth & development/*physiology
MH  - Female
MH  - Heat-Shock Response/*genetics
MH  - JNK Mitogen-Activated Protein Kinases/genetics/metabolism
MH  - *MAP Kinase Signaling System
MH  - Male
MH  - Mitogen-Activated Protein Kinases/*genetics/metabolism
MH  - p38 Mitogen-Activated Protein Kinases/genetics/metabolism
PMC - PMC7587847
OTO - NOTNLM
OT  - HPG axis
OT  - MAPKs
OT  - Wenchang chick
OT  - heat stress
EDAT- 2020/05/18 06:00
MHDA- 2021/01/06 06:00
PMCR- 2019/12/30
CRDT- 2020/05/18 06:00
PHST- 2019/06/14 00:00 [received]
PHST- 2019/08/12 00:00 [accepted]
PHST- 2020/05/18 06:00 [entrez]
PHST- 2020/05/18 06:00 [pubmed]
PHST- 2021/01/06 06:00 [medline]
PHST- 2019/12/30 00:00 [pmc-release]
AID - S0032-5791(19)57901-9 [pii]
AID - 10.3382/ps/pez499 [doi]
PST - ppublish
SO  - Poult Sci. 2020 Jan;99(1):567-577. doi: 10.3382/ps/pez499. Epub 2019 Dec 30.