PMID- 32417596
OWN - NLM
STAT- MEDLINE
DCOM- 20201111
LR  - 20221207
IS  - 1872-8421 (Electronic)
IS  - 0165-5728 (Linking)
VI  - 344
DP  - 2020 Jul 15
TI  - Novel findings of HLA association with anti-LGI1 encephalitis: HLA-DRB1*03:01 and 
      HLA-DQB1*02:01.
PG  - 577243
LID - S0165-5728(19)30657-5 [pii]
LID - 10.1016/j.jneuroim.2020.577243 [doi]
AB  - This study was to investigate whether autoimmune encephalitis is associated with 
      the human leukocyte antigen (HLA) genotypes in Chinese Han population. We 
      compared and analyzed the HLA genotypes of 101 patients with autoimmune 
      encephalitis (77 anti-NMDAR, 11 anti-LGI1 and 13 anti-GABA(B)R antibody, 
      respectively) to the 200 healthy control groups. Our results showed that the 
      DRB1*03:01 or DQB1*02:01 allele and the extended DRB1*03:01 ~ DQB1*02:01 
      haplotype represented the strong susceptibility locus for anti-LGI1 encephalitis 
      (OR = 18.84, 95% CI = 5.01-70.89, Pc = 0.004; OR = 18.84, 95% CI = 5.01-70.89, 
      Pc = 0.004; OR = 18.84, 95% CI = 5.01-70.89, Pc = 0.001). Additionally, the 
      DRB1*08:03 ~ DQB1*06:01 or B*08:01 ~ C*07:02 haplotype was likely to be 
      associated with anti-LGI1 encephalitis (OR = 10.23, 95% CI = 2.87-36.42, 
      Pc = 0.039; OR = 74.62, 95% CI = 6.97-799.06, Pc = 0.043). No statistically 
      significant differences were found for HLA association between patients with 
      anti-NMDAR or anti-GABA(B)R encephalitis and healthy controls. These results 
      indicated that HLA subtypes were only associated with anti-LGI1 encephalitis.
CI  - Copyright (c) 2020. Published by Elsevier B.V.
FAU - Hu, Fayun
AU  - Hu F
AD  - Department of Neurology, West China Hospital, Sichuan University, Chengdu, 
      Sichuan 610041, People's Republic of China.
FAU - Liu, Xu
AU  - Liu X
AD  - Department of Neurology, West China Hospital, Sichuan University, Chengdu, 
      Sichuan 610041, People's Republic of China.
FAU - Zhang, Le
AU  - Zhang L
AD  - Department of Neurology, West China Hospital, Sichuan University, Chengdu, 
      Sichuan 610041, People's Republic of China.
FAU - Chen, Chu
AU  - Chen C
AD  - Department of Neurology, West China Hospital, Sichuan University, Chengdu, 
      Sichuan 610041, People's Republic of China.
FAU - Gong, Xue
AU  - Gong X
AD  - Department of Neurology, West China Hospital, Sichuan University, Chengdu, 
      Sichuan 610041, People's Republic of China.
FAU - Lin, Jingfang
AU  - Lin J
AD  - Department of Neurology, West China Hospital, Sichuan University, Chengdu, 
      Sichuan 610041, People's Republic of China.
FAU - An, Dongmei
AU  - An D
AD  - Department of Neurology, West China Hospital, Sichuan University, Chengdu, 
      Sichuan 610041, People's Republic of China.
FAU - Zhou, Dong
AU  - Zhou D
AD  - Department of Neurology, West China Hospital, Sichuan University, Chengdu, 
      Sichuan 610041, People's Republic of China. Electronic address: 
      zhoudong66@yahoo.de.
FAU - Hong, Zhen
AU  - Hong Z
AD  - Department of Neurology, West China Hospital, Sichuan University, Chengdu, 
      Sichuan 610041, People's Republic of China. Electronic address: 
      hongzhengoog@aliyun.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20200415
PL  - Netherlands
TA  - J Neuroimmunol
JT  - Journal of neuroimmunology
JID - 8109498
RN  - 0 (HLA-DQ beta-Chains)
RN  - 0 (HLA-DQB1 antigen)
RN  - 0 (HLA-DRB1 Chains)
RN  - 0 (HLA-DRB1*03:01 antigen)
RN  - 0 (Intracellular Signaling Peptides and Proteins)
RN  - 0 (LGI1 protein, human)
RN  - Hashimoto's encephalitis
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Asian People/*genetics
MH  - Encephalitis/*diagnosis/*genetics
MH  - Female
MH  - HLA-DQ beta-Chains/*genetics
MH  - HLA-DRB1 Chains/*genetics
MH  - Hashimoto Disease/*diagnosis/*genetics
MH  - Humans
MH  - Intracellular Signaling Peptides and Proteins/*genetics
MH  - Male
MH  - Middle Aged
MH  - Prospective Studies
MH  - Retrospective Studies
MH  - Young Adult
OTO - NOTNLM
OT  - Anti-GABA(B) antibody
OT  - Anti-LGI1 antibody
OT  - Anti-NMDAR antibody
OT  - Autoimmune encephalitis
OT  - HLA gene
EDAT- 2020/05/18 06:00
MHDA- 2020/11/12 06:00
CRDT- 2020/05/18 06:00
PHST- 2019/12/12 00:00 [received]
PHST- 2020/04/04 00:00 [revised]
PHST- 2020/04/14 00:00 [accepted]
PHST- 2020/05/18 06:00 [pubmed]
PHST- 2020/11/12 06:00 [medline]
PHST- 2020/05/18 06:00 [entrez]
AID - S0165-5728(19)30657-5 [pii]
AID - 10.1016/j.jneuroim.2020.577243 [doi]
PST - ppublish
SO  - J Neuroimmunol. 2020 Jul 15;344:577243. doi: 10.1016/j.jneuroim.2020.577243. Epub 
      2020 Apr 15.