PMID- 32418670 OWN - NLM STAT- MEDLINE DCOM- 20210331 LR - 20210331 IS - 1365-229X (Electronic) IS - 0009-9260 (Linking) VI - 75 IP - 8 DP - 2020 Aug TI - Quantification of late gadolinium enhancement cardiovascular MRI in patients with coronary artery chronic total occlusion. PG - 643.e19-643.e26 LID - S0009-9260(20)30136-7 [pii] LID - 10.1016/j.crad.2020.03.032 [doi] AB - AIM: To determine the most accurate and reproducible semi-automated greyscale thresholding technique for quantifying late gadolinium enhancement (LGE) in cardiovascular magnetic resonance imaging (CMRI), by using positron-emission tomography (PET) as the reference standard in patients with coronary artery chronic total occlusion (CTO). MATERIALS AND METHODS: LGE in CMRI, single-photon-emission computed tomography (SPECT), and PET were performed within 1 week in each of 63 patients with known CTO. The presence and quantity of LGE were determined with greyscale thresholds of 2, 4, 5, 6, and 8 standard deviations (SDs) above the mean signal intensity for normal remote myocardium and full width at half maximum (FWHM). The infarcted myocardium was delineated by PET. RESULTS: Sixty-three patients and 1,008 segments were analysed. Based on patient analysis, with PET as the reference standard, the 5 SD method yielded the strongest correlation (r=0.85, p<0.0001) compared with the 2 SDs (r=0.42), 4 SDs (r=0.73), 6 SDs (r=0.81), 8 SDs (r=0.71), and FWHM (r=0.69; p<0.001 for all comparisons). The 5 SDs threshold quantification showed high interobserver and intra-observer agreement (intraclass correlation coefficient [ICC]=0.90, p<0.0001; ICC=0.93, p<0.0001, respectively). CONCLUSIONS: Semi-automated LGE CMRI greyscale thresholding with 5 SDs above the mean signal intensity for normal remote myocardium yields the strongest correlation to the extent of LGE identified using PET and is highly reproducible in patients with CTO. CI - Copyright (c) 2020. Published by Elsevier Ltd. FAU - Zhang, L J AU - Zhang LJ AD - Department of Radiology, Beijing Anzhen Hospital, Capital Medical University, Beijing, China. FAU - Dong, W AU - Dong W AD - Department of Nuclear Medicine, Beijing Anzhen Hospital, Capital Medical University, Beijing, China. FAU - Li, J N AU - Li JN AD - Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing, China. FAU - Mi, H Z AU - Mi HZ AD - Department of Nuclear Medicine, Beijing Anzhen Hospital, Capital Medical University, Beijing, China. FAU - Jiao, J AU - Jiao J AD - Department of Nuclear Medicine, Beijing Anzhen Hospital, Capital Medical University, Beijing, China. FAU - Dou, R Y AU - Dou RY AD - Department of Radiology, Beijing Anzhen Hospital, Capital Medical University, Beijing, China. FAU - An, J AU - An J AD - Siemens Shenzhen Magnetic Resonance Ltd, China. FAU - Liu, J L AU - Liu JL AD - Center for Cardiopulmonary Research, Beijing Anzhen Hospital, Capital Medical University, Beijing, China. FAU - He, Y AU - He Y AD - Department of Radiology, Beijing Anzhen Hospital, Capital Medical University, Beijing, China. Electronic address: Heyi139@sina.com. FAU - Song, X T AU - Song XT AD - Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing, China. Electronic address: songxiantao0929@qq.com. LA - eng PT - Journal Article DEP - 20200515 PL - England TA - Clin Radiol JT - Clinical radiology JID - 1306016 RN - 0 (Contrast Media) RN - K2I13DR72L (Gadolinium DTPA) SB - IM MH - Contrast Media/pharmacology MH - Coronary Occlusion/*diagnosis MH - Coronary Vessels/*diagnostic imaging MH - Female MH - Gadolinium DTPA/*pharmacology MH - Humans MH - Image Enhancement/*methods MH - Magnetic Resonance Imaging, Cine/*methods MH - Male MH - Middle Aged MH - Predictive Value of Tests MH - Tomography, Emission-Computed, Single-Photon/methods EDAT- 2020/05/19 06:00 MHDA- 2021/04/01 06:00 CRDT- 2020/05/19 06:00 PHST- 2019/12/30 00:00 [received] PHST- 2020/03/19 00:00 [accepted] PHST- 2020/05/19 06:00 [pubmed] PHST- 2021/04/01 06:00 [medline] PHST- 2020/05/19 06:00 [entrez] AID - S0009-9260(20)30136-7 [pii] AID - 10.1016/j.crad.2020.03.032 [doi] PST - ppublish SO - Clin Radiol. 2020 Aug;75(8):643.e19-643.e26. doi: 10.1016/j.crad.2020.03.032. Epub 2020 May 15.