PMID- 32419214
OWN - NLM
STAT- MEDLINE
DCOM- 20210818
LR  - 20210818
IS  - 1365-2265 (Electronic)
IS  - 0300-0664 (Linking)
VI  - 93
IP  - 4
DP  - 2020 Oct
TI  - The clinical expression and impact of multiple endocrine neoplasia 1 during 
      pregnancy.
PG  - 429-438
LID - 10.1111/cen.14252 [doi]
AB  - CONTEXT: Multiple endocrine neoplasia type 1 (MEN 1) is characterized by 
      multisystem neoplasia including primary hyperparathyroidism and pituitary 
      adenoma. Despite the adolescent onset of endocrinopathies, information regarding 
      the impact of maternal MEN 1 on pregnancy is limited to case reports. OBJECTIVE: 
      To explore pregnancy outcomes in MEN 1 positive women. METHODS: Retrospective 
      case series of maternofoetal outcomes MEN 1 positive mothers managed at the Royal 
      Hobart Hospital between 1967 and 2018. Data were retrieved from medical records 
      and Australian averages calculated based on the Australian Institute of Health 
      and Welfare data. RESULTS: Twenty-six women with MEN 1 were identified accounting 
      for 96 pregnancies and 76 live born infants. Hyperparathyroidism was evident in 
      16 pregnancies. A significant increase in serum calcium in the second trimester 
      (beta = 0.14, P < .001) occurred that was not mediated by parathyroid hormone. 
      Hypercalcaemia was mild-moderate with parathyroidectomy or medical management 
      required in one and four pregnancies, respectively. Compared to the Australian 
      average, women with MEN 1 were more likely to develop gestational diabetes (56% 
      vs 8.9%, P = .001), hypertensive disorders (25.9% vs 7.6, P = .018), have shorter 
      gestations (38.1 vs 38.7 weeks, P = .015) and have low birthweight infants (30.1% 
      vs 6.5%, P = .001). However, emergency caesarean deliveries (63.2% vs 52.3%) and 
      miscarriage rate (20.8% vs 20%) were not significantly different. CONCLUSION: 
      Maternal MEN 1 is associated with an increased risk of gestational diabetes, 
      hypertensive disorders and low neonatal birthweight, but not with an increased 
      miscarriage rate. Whilst hypercalcaemia worsens during the second trimester, most 
      pregnancies progressed without overt complications or requirement for 
      intervention.
CI  - (c) 2020 John Wiley & Sons Ltd.
FAU - Hogg, Prudence
AU  - Hogg P
AUID- ORCID: 0000-0002-6225-9240
AD  - Department of General Medicine, Royal Hobart Hospital, Hobart, Tasmania, 
      Australia.
FAU - Thompson, Michael
AU  - Thompson M
AUID- ORCID: 0000-0003-1425-5808
AD  - Department of Diabetes and Endocrinology, Royal Hobart Hospital, Hobart, 
      Tasmania, Australia.
AD  - School of Medicine, University of Tasmania, Hobart, Tasmania, Australia.
FAU - Burgess, John
AU  - Burgess J
AD  - Department of Diabetes and Endocrinology, Royal Hobart Hospital, Hobart, 
      Tasmania, Australia.
AD  - School of Medicine, University of Tasmania, Hobart, Tasmania, Australia.
LA  - eng
PT  - Journal Article
DEP - 20200611
PL  - England
TA  - Clin Endocrinol (Oxf)
JT  - Clinical endocrinology
JID - 0346653
SB  - IM
MH  - Adolescent
MH  - Australia
MH  - Cesarean Section
MH  - Female
MH  - Humans
MH  - Infant
MH  - Infant, Newborn
MH  - *Multiple Endocrine Neoplasia Type 1
MH  - Pregnancy
MH  - *Pregnancy Outcome
MH  - Retrospective Studies
OTO - NOTNLM
OT  - MEN 1
OT  - clinical management
OT  - multiple endocrine neoplasia type 1
OT  - phenotype
OT  - pregnancy
OT  - young adult
EDAT- 2020/05/19 06:00
MHDA- 2021/08/19 06:00
CRDT- 2020/05/19 06:00
PHST- 2020/03/21 00:00 [received]
PHST- 2020/04/29 00:00 [revised]
PHST- 2020/05/08 00:00 [accepted]
PHST- 2020/05/19 06:00 [pubmed]
PHST- 2021/08/19 06:00 [medline]
PHST- 2020/05/19 06:00 [entrez]
AID - 10.1111/cen.14252 [doi]
PST - ppublish
SO  - Clin Endocrinol (Oxf). 2020 Oct;93(4):429-438. doi: 10.1111/cen.14252. Epub 2020 
      Jun 11.