PMID- 32419454
OWN - NLM
STAT- MEDLINE
DCOM- 20210111
LR  - 20210111
IS  - 1520-5118 (Electronic)
IS  - 0021-8561 (Linking)
VI  - 68
IP  - 23
DP  - 2020 Jun 10
TI  - Prebiotic Properties of Green and Dark Tea Contribute to Protective Effects in 
      Chemical-Induced Colitis in Mice: A Fecal Microbiota Transplantation Study.
PG  - 6368-6380
LID - 10.1021/acs.jafc.0c02336 [doi]
AB  - Green and dark tea extract (GTE/DTE) ameliorate chemical-induced colitis in mice; 
      however, the role of gut microbiota in the anticolitis effects of green and dark 
      tea in mice remains unclear. This study aims to explore the role of modulations 
      in gut microbes mediated by green and dark tea in colitis mice by fecal 
      microbiota transplantation (FMT). Our results indicated that GTE and DTE (5 mg/kg 
      bodyweight/day for 4 weeks) exhibited prebiotic effects on the donor mice. 
      Moreover, the FMT treatments (transferring the microbiota daily from the 1 g/kg 
      bodyweight fecal sample to each recipient) indicated that, compared with the 
      fecal microbiota from the normal diet-treated donor mice, the fecal microbiota 
      from the GTE- and DTE-treated donor mice significantly ameliorate colitis-related 
      symptoms (e.g., loss of bodyweight, colonic inflammation, loss of barrier 
      integrity, and gut microbiota dysbiosis) and downregulated the TLR4/MyD88/NF-kappaB 
      pathway. Collectively, GTE and DTE ameliorate chemical-induced colitis by 
      modulating gut microbiota.
FAU - Liu, Yan
AU  - Liu Y
AUID- ORCID: 0000-0003-3677-9290
AD  - College of Food Science, Southwest University, Beibei, Chongqing 400715, People's 
      Republic of China.
FAU - Luo, Liyong
AU  - Luo L
AD  - College of Food Science, Southwest University, Beibei, Chongqing 400715, People's 
      Republic of China.
AD  - Tea Research Institute, Southwest University, Beibei, Chongqing 400715, People's 
      Republic of China.
FAU - Luo, Yakun
AU  - Luo Y
AD  - Tea Research Institute of Puer, Puer, Yunnan 665000, People's Republic of China.
FAU - Zhang, Jun
AU  - Zhang J
AD  - Tea Research Institute of Puer, Puer, Yunnan 665000, People's Republic of China.
FAU - Wang, Xinghua
AU  - Wang X
AD  - Tea Research Institute of Puer, Puer, Yunnan 665000, People's Republic of China.
FAU - Sun, Kang
AU  - Sun K
AD  - College of Food Science, Southwest University, Beibei, Chongqing 400715, People's 
      Republic of China.
AD  - Tea Research Institute, Southwest University, Beibei, Chongqing 400715, People's 
      Republic of China.
FAU - Zeng, Liang
AU  - Zeng L
AUID- ORCID: 0000-0003-3860-7724
AD  - College of Food Science, Southwest University, Beibei, Chongqing 400715, People's 
      Republic of China.
AD  - Tea Research Institute, Southwest University, Beibei, Chongqing 400715, People's 
      Republic of China.
LA  - eng
PT  - Journal Article
DEP - 20200528
PL  - United States
TA  - J Agric Food Chem
JT  - Journal of agricultural and food chemistry
JID - 0374755
RN  - 0 (Plant Extracts)
RN  - 0 (Prebiotics)
RN  - 0 (Tea)
SB  - IM
MH  - Animals
MH  - Camellia sinensis/*chemistry
MH  - Colitis/drug therapy/etiology/*therapy
MH  - *Fecal Microbiota Transplantation
MH  - Gastrointestinal Microbiome/drug effects
MH  - Humans
MH  - Mice
MH  - Plant Extracts/*administration & dosage
MH  - Prebiotics/administration & dosage
MH  - Tea/chemistry
OTO - NOTNLM
OT  - Camellia sinensis
OT  - colitis
OT  - dark tea
OT  - fecal microbiota transplantation
OT  - green tea
EDAT- 2020/05/19 06:00
MHDA- 2021/01/12 06:00
CRDT- 2020/05/19 06:00
PHST- 2020/05/19 06:00 [pubmed]
PHST- 2021/01/12 06:00 [medline]
PHST- 2020/05/19 06:00 [entrez]
AID - 10.1021/acs.jafc.0c02336 [doi]
PST - ppublish
SO  - J Agric Food Chem. 2020 Jun 10;68(23):6368-6380. doi: 10.1021/acs.jafc.0c02336. 
      Epub 2020 May 28.