PMID- 32420179
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200928
IS  - 2223-4691 (Print)
IS  - 2223-4691 (Electronic)
IS  - 2223-4683 (Linking)
VI  - 9
IP  - 2
DP  - 2020 Apr
TI  - Urinary biomarkers in pelvic-ureteric junction obstruction: a systematic review.
PG  - 722-742
LID - 10.21037/tau.2020.01.01 [doi]
AB  - Antenatal hydronephrosis is a common finding detected on prenatal ultrasound. 
      Although hydronephrosis will spontaneously resolve in the majority of newborns, 
      there is a significant amount of cases that will worsen with the risk of a 
      progressive and permanent loss of renal function. There is an increasing concern 
      among experts that the current criteria for evaluation of clinically significant 
      obstructions are limited. Our aim is to provide a systematic review of the 
      available literature on biomarkers of renal injury, potential targets for 
      diagnosis and prognosis of children with hydronephrosis. The main search was 
      conducted in the electronic databases from inception through March 2019 using 
      various combinations of the keywords: pelvic-ureteric [All Fields] AND junction 
      [All Fields] AND obstruction [All Fields] AND "biomarkers" [MeSH Terms] OR 
      "biomarkers" [All Fields] OR "biomarker" [All Fields]. To broaden the research, 
      additional articles were identified through hand-searching review of the 
      references reported in each study previously selected. Histopathological studies, 
      studies with no control group or with participants suffering from concomitant 
      urological diseases and articles published in language other than English were 
      excluded. Data on study design, sample size, average patient age, hydronephrosis 
      definition used, surgical indication, duration and pattern of follow-up, details 
      on biomarker studied, diagnostic test characteristics, area under the curve (AUC) 
      on receiver operating characteristic (ROC) analysis with the best cut-off (BCO) 
      values, sensitivity, specificity and outcomes were all collected. 38 articles 
      analysing 41 biomarkers were selected. The most frequent proteins investigated 
      were neutrophil gelatinase-associated lipocalin (NGAL) (n=9; 23.7%), monocyte 
      chemotactic peptide-1 (MCP1) (n=8; 21.1%), transforming growth factor beta1 (TGFbeta1) 
      (n=7; 18.4%), epidermal growth factor (EGF) (n=6; 15.8%) and kidney injury 
      molecule 1 (KIM 1) (n=6; 15.8%). Twenty-seven (71.1%) studies evaluated the 
      effect of pyeloplasty on voided urine biomarker concentrations, comparing their 
      values before and after surgery. Twelve (31.6%) studies investigated the 
      correlation between preoperative biomarker concentration and the anterior 
      posterior renal pelvis diameter (DAP) while 20 (52.6%) studies investigated the 
      correlation between preoperative biomarker concentration with the split renal 
      function (SRF) measured on nuclear medicine assessments. ROC curves were used to 
      investigate the performance of urinary biomarkers in the total patient data set 
      in 27 (71.1%) studies. Some biomarkers offer promising results. However, a critic 
      analysis of the published studies demonstrates bias and lack of consistency 
      suggesting that larger multicentre and carefully designed prospective studies are 
      still needed to evaluate the clinical usefulness of urinary biomarkers in the 
      diagnosis and follow-up of children with congenital obstructive hydronephrosis.
CI  - 2020 Translational Andrology and Urology. All rights reserved.
FAU - Paraboschi, Irene
AU  - Paraboschi I
AD  - Paediatric Surgery Unit, Istituto Giannina Gaslini, DiNOGMI, University of 
      Genova, Genoa, Italy.
FAU - Mantica, Guglielmo
AU  - Mantica G
AD  - Department of Urology, Policlinico San Martino Hospital, University of Genova, 
      Genova, Italy.
FAU - Dalton, Neil R
AU  - Dalton NR
AD  - WellChild Laboratory, Evelina London Children's Hospital, Guy's and St Thomas' 
      National Health Service Foundation Trust, London, UK.
FAU - Turner, Charles
AU  - Turner C
AD  - WellChild Laboratory, Evelina London Children's Hospital, Guy's and St Thomas' 
      National Health Service Foundation Trust, London, UK.
FAU - Garriboli, Massimo
AU  - Garriboli M
AD  - Paediatric Urology, Evelina London Children's Hospital, London, UK.
LA  - eng
PT  - Journal Article
PT  - Review
PL  - China
TA  - Transl Androl Urol
JT  - Translational andrology and urology
JID - 101581119
PMC - PMC7215034
OTO - NOTNLM
OT  - Pelvic-ureteric junction obstruction (PUJO)
OT  - biomarkers
OT  - hydronephrosis
OT  - kidney injury
COIS- Conflicts of Interest: All authors have completed the ICMJE uniform disclosure 
      form (available at http://dx.doi.org/10.21037/tau.2020.01.01). NRD and CT report 
      other from SpOtOn Clinical Diagnostics Ltd, NRD and CT have a patent Stable 
      isotope albumin peptide internal standard issued. The other authors have no 
      conflicts of interest to declare.
EDAT- 2020/05/19 06:00
MHDA- 2020/05/19 06:01
PMCR- 2020/04/01
CRDT- 2020/05/19 06:00
PHST- 2020/05/19 06:00 [entrez]
PHST- 2020/05/19 06:00 [pubmed]
PHST- 2020/05/19 06:01 [medline]
PHST- 2020/04/01 00:00 [pmc-release]
AID - tau-09-02-722 [pii]
AID - 10.21037/tau.2020.01.01 [doi]
PST - ppublish
SO  - Transl Androl Urol. 2020 Apr;9(2):722-742. doi: 10.21037/tau.2020.01.01.