PMID- 32420383
OWN - NLM
STAT- MEDLINE
DCOM- 20210210
LR  - 20221207
IS  - 2314-6141 (Electronic)
IS  - 2314-6133 (Print)
VI  - 2020
DP  - 2020
TI  - Prevalence of Hyperhomocysteinaemia and Associated Factors among Ethiopian Adult 
      Population in a 2015 National Survey.
PG  - 9210261
LID - 10.1155/2020/9210261 [doi]
LID - 9210261
AB  - Hyperhomocysteinaemia (HHcy) is an independent risk factor for major 
      cardiovascular diseases, but data on the prevalence and predictors of HHcy in 
      low- and middle-income countries like Ethiopia are scant. The aim of this study 
      was to estimate the prevalence of HHcy and associated risk factors in the 
      Ethiopian adult population. A cross-sectional survey on risks of noncommunicable 
      diseases (NCDs) using the STEPwise approach to surveillance (STEPS) survey was 
      conducted between April and June 2015. A total of 4,175 study participants were 
      surveyed. Serum homocysteine (Hcy) and metabolic profile were determined using 
      Cobas Integra 400 Plus and CardioChek PA analyzer, respectively. Factors 
      associated with HHcy were determined using logistic regression. The mean serum 
      tHcy concentration was 14.6 mumol/L, with 16.4 mumol/L in males and 13.4 mumol/L in 
      females. Overall, 38% had HHcy, with figures in males (49%) higher than females 
      (30%). Increased age, being male, and high blood pressure and/or taking blood 
      pressure medication, as well as low consumption of fruit and/or vegetables, were 
      independent risk factors for HHcy. In conclusion, the prevalence of HHcy among 
      the adult Ethiopian population is alarmingly high. Improving diets through the 
      promotion of fruit and vegetable consumption is needed to reduce the risk of 
      NCDs.
CI  - Copyright (c) 2020 Feyissa Challa et al.
FAU - Challa, Feyissa
AU  - Challa F
AUID- ORCID: 0000-0002-2624-6661
AD  - National References Laboratory for Clinical Chemistry, Ethiopian Public Health 
      Institute, Addis Ababa, Ethiopia.
FAU - Getahun, Tigist
AU  - Getahun T
AD  - National References Laboratory for Clinical Chemistry, Ethiopian Public Health 
      Institute, Addis Ababa, Ethiopia.
FAU - Sileshi, Meron
AU  - Sileshi M
AD  - National References Laboratory for Clinical Chemistry, Ethiopian Public Health 
      Institute, Addis Ababa, Ethiopia.
FAU - Nigassie, Bikila
AU  - Nigassie B
AUID- ORCID: 0000-0001-5419-9770
AD  - National References Laboratory for Clinical Chemistry, Ethiopian Public Health 
      Institute, Addis Ababa, Ethiopia.
FAU - Geto, Zeleke
AU  - Geto Z
AUID- ORCID: 0000-0001-8332-8885
AD  - National References Laboratory for Clinical Chemistry, Ethiopian Public Health 
      Institute, Addis Ababa, Ethiopia.
FAU - Ashibire, Genet
AU  - Ashibire G
AD  - National References Laboratory for Clinical Chemistry, Ethiopian Public Health 
      Institute, Addis Ababa, Ethiopia.
FAU - Gelibo, Terefe
AU  - Gelibo T
AUID- ORCID: 0000-0001-7591-9669
AD  - ICAP-CU, Addis Ababa, Ethiopia.
FAU - Teferra, Solomon
AU  - Teferra S
AD  - Department of Psychiatry, School of Medicine, College of Health Sciences, Addis 
      Ababa University, Addis Ababa, Ethiopia.
FAU - Seifu, Daniel
AU  - Seifu D
AD  - Department of Biochemistry, School of Medicine, College of Health Sciences, Addis 
      Ababa University, Addis Ababa, Ethiopia.
FAU - Sitotaw, Yohannes
AU  - Sitotaw Y
AD  - Ethiopian Biotechnology Institute, Addis Ababa, Ethiopia.
FAU - Bekele, Abebe
AU  - Bekele A
AD  - Health System and Reproductive Health Research Directorate, Ethiopian Public 
      Health Institute, Addis Ababa, Ethiopia.
FAU - Abate, Ebba
AU  - Abate E
AD  - National References Laboratory for Clinical Chemistry, Ethiopian Public Health 
      Institute, Addis Ababa, Ethiopia.
FAU - Baye, Kaleab
AU  - Baye K
AD  - Center for Food Science and Nutrition, College of Natural Sciences, Addis Ababa 
      University, Addis Ababa, Ethiopia.
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PT  - Multicenter Study
DEP - 20200111
PL  - United States
TA  - Biomed Res Int
JT  - BioMed research international
JID - 101600173
RN  - 0LVT1QZ0BA (Homocysteine)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Age Factors
MH  - Aged
MH  - Black People
MH  - Cross-Sectional Studies
MH  - Ethiopia/epidemiology
MH  - Female
MH  - Food Preferences
MH  - Homocysteine/blood
MH  - Humans
MH  - Hyperhomocysteinemia/blood/*epidemiology
MH  - Hypertension/blood/*epidemiology
MH  - Male
MH  - Middle Aged
MH  - Prevalence
MH  - Risk Factors
MH  - Sex Factors
PMC - PMC7201487
COIS- The authors declare that they have no conflicts of interest.
EDAT- 2020/05/19 06:00
MHDA- 2021/02/11 06:00
PMCR- 2020/01/11
CRDT- 2020/05/19 06:00
PHST- 2019/07/22 00:00 [received]
PHST- 2019/12/16 00:00 [accepted]
PHST- 2020/05/19 06:00 [entrez]
PHST- 2020/05/19 06:00 [pubmed]
PHST- 2021/02/11 06:00 [medline]
PHST- 2020/01/11 00:00 [pmc-release]
AID - 10.1155/2020/9210261 [doi]
PST - epublish
SO  - Biomed Res Int. 2020 Jan 11;2020:9210261. doi: 10.1155/2020/9210261. eCollection 
      2020.