PMID- 32420867
OWN - NLM
STAT- MEDLINE
DCOM- 20210317
LR  - 20210317
IS  - 2050-084X (Electronic)
IS  - 2050-084X (Linking)
VI  - 9
DP  - 2020 May 18
TI  - Retrieval practice facilitates memory updating by enhancing and differentiating 
      medial prefrontal cortex representations.
LID - 10.7554/eLife.57023 [doi]
LID - e57023
AB  - Updating old memories with new, more current information is critical for human 
      survival, yet the neural mechanisms for memory updating in general and the effect 
      of retrieval practice in particular are poorly understood. Using a three-day 
      A-B/A-C memory updating paradigm, we found that compared to restudy, retrieval 
      practice could strengthen new A-C memories and reduce old A-B memory intrusion, 
      but did not suppress A-B memories. Neural activation pattern analysis revealed 
      that compared to restudy, retrieval practice led to stronger target 
      representation in the medial prefrontal cortex (MPFC) during the final test. 
      Critically, it was only under the retrieval practice condition that the MPFC 
      showed strong and comparable competitor evidence for both correct and incorrect 
      trials during final test, and that the MPFC target representation during updating 
      was predictive of subsequent memory. These results suggest that retrieval 
      practice is able to facilitate memory updating by strongly engaging MPFC 
      mechanisms in memory integration, differentiation and consolidation.
CI  - (c) 2020, Ye et al.
FAU - Ye, Zhifang
AU  - Ye Z
AUID- ORCID: 0000-0003-0489-2619
AD  - State Key Laboratory of Cognitive Neuroscience and Learning & IDG/McGovern 
      Institute of Brain Research, Beijing Normal University, Beijing, China.
FAU - Shi, Liang
AU  - Shi L
AD  - State Key Laboratory of Cognitive Neuroscience and Learning & IDG/McGovern 
      Institute of Brain Research, Beijing Normal University, Beijing, China.
FAU - Li, Anqi
AU  - Li A
AD  - State Key Laboratory of Cognitive Neuroscience and Learning & IDG/McGovern 
      Institute of Brain Research, Beijing Normal University, Beijing, China.
FAU - Chen, Chuansheng
AU  - Chen C
AD  - Department of Psychological Science, University of California, Irvine, Irvine, 
      United States.
FAU - Xue, Gui
AU  - Xue G
AUID- ORCID: 0000-0001-7891-8151
AD  - State Key Laboratory of Cognitive Neuroscience and Learning & IDG/McGovern 
      Institute of Brain Research, Beijing Normal University, Beijing, China.
LA  - eng
GR  - 31730038/National Science Foundation of China/International
GR  - 31861143040/The NSFC and the Israel Science Foundation joint 
      project/International
GR  - 61621136008/National Science Foundation of China/International
GR  - TRR-169/German Research Foundation/International
GR  - 2016ZT06S220/Guangdong Pearl River Talents Plan Innovative and Entrepreneurial 
      Team grant/International
GR  - 31861143040/The NSFC and the Israel Science Foundation (ISF) joint 
      project/International
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20200518
PL  - England
TA  - Elife
JT  - eLife
JID - 101579614
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Association Learning/physiology
MH  - Female
MH  - Hippocampus/*physiology
MH  - Humans
MH  - Male
MH  - Memory Consolidation/*physiology
MH  - Mental Recall/*physiology
MH  - Prefrontal Cortex/*physiology
MH  - Young Adult
PMC - PMC7272192
OTO - NOTNLM
OT  - human
OT  - memory reactivation
OT  - memory updating
OT  - neuroscience
OT  - retrieval practice effect
COIS- ZY, LS, AL, CC, GX No competing interests declared
EDAT- 2020/05/19 06:00
MHDA- 2021/03/18 06:00
PMCR- 2020/05/18
CRDT- 2020/05/19 06:00
PHST- 2020/03/18 00:00 [received]
PHST- 2020/05/18 00:00 [accepted]
PHST- 2020/05/19 06:00 [pubmed]
PHST- 2021/03/18 06:00 [medline]
PHST- 2020/05/19 06:00 [entrez]
PHST- 2020/05/18 00:00 [pmc-release]
AID - 57023 [pii]
AID - 10.7554/eLife.57023 [doi]
PST - epublish
SO  - Elife. 2020 May 18;9:e57023. doi: 10.7554/eLife.57023.