PMID- 32421184
OWN - NLM
STAT- MEDLINE
DCOM- 20201026
LR  - 20201026
IS  - 2574-3805 (Electronic)
IS  - 2574-3805 (Linking)
VI  - 3
IP  - 5
DP  - 2020 May 1
TI  - Association of Prenatal Exposure to Ambient Air Pollution With Circulating 
      Histone Levels in Maternal Cord Blood.
PG  - e205156
LID - 10.1001/jamanetworkopen.2020.5156 [doi]
LID - e205156
AB  - IMPORTANCE: Exposure to ambient air pollution has been associated with the risk 
      of carcinogenesis in later life. Changes in histone modifications might have 
      long-term adverse health effects. OBJECTIVE: To investigate the association of 
      prenatal exposure to ambient air pollution with levels of circulating total 
      histone H3 and specific trimethylation marks (ie, H3 lysine 4, H3 lysine 36) in 
      maternal cord blood. DESIGN, SETTING, AND PARTICIPANTS: The Environmental 
      Influence on Aging (ENVIRONAGE) birth cohort study included 609 mothers and their 
      newborns. Participants were recruited when mothers entered the Hospital East 
      Limburg (Genk, Belgium) for delivery between February 2010 and January 2017. The 
      inclusion criteria were singleton pregnancies and the ability to fill out 
      questionnaires in Dutch. Data analysis was conducted from March to August 2019. 
      EXPOSURES: Exposure to particulate matter with a diameter less than 2.5 mum 
      (PM2.5), black carbon, and nitrogen dioxide during pregnancy was modeled with a 
      high-resolution air pollution model on the basis of maternal address for each 
      trimester of pregnancy as well as for the entire pregnancy. MAIN OUTCOMES AND 
      MEASURES: Circulating total histone H3 levels and specific trimethylation marks 
      (ie, trimethylated H3 lysine 4 and trimethylated H3 lysine 36) in cord blood. 
      RESULTS: A total of 609 mother-newborn pairs were included in the study. Mean 
      (SD) maternal age was 29.3 (4.6) years, 391 mothers (64.2%) never smoked, and 314 
      (51.3%) had a high education level. Overall, 322 newborns (52.4%) were boys, and 
      mean (SD) birth weight was 3414 (485) g. Participants experienced mean (SD) 
      exposure to PM2.5, black carbon, and nitrogen dioxide of 13.4 (2.6) mug/m3, 1.29 
      (0.31) mug/m3, and 17.98 (4.57) mug/m3, respectively, during their entire 
      pregnancies. Trimethylated H3 lysine 4 and total histone H3 were positively 
      associated with gestational PM2.5 exposure, with a 74.4% increment (95% CI, 26.7% 
      to 140.2%, P < .001) and a 40.2% increment (95% CI, 24.1% to 58.3%, P < .001), 
      respectively, observed for each 5-mug/m3 increase in PM2.5 exposure during the 
      entire pregnancy. For the same exposure window, trimethylated H3 lysine 36 levels 
      were inversely associated with PM2.5 exposure (-34.4%; 95% CI, -50.1% to -13.7%; 
      P = .003). Exposure to black carbon during the entire pregnancy was positively 
      associated with trimethylated H3 lysine 4 (38.4%; 95% CI, 6.2% to 80.3%; 
      P = .003). CONCLUSIONS AND RELEVANCE: Associations of ambient air pollution with 
      cord plasma histone H3 modifications during early life might indicate that 
      circulating histones are a risk factor in the development of air 
      pollution-associated disease later in life. Additional study is required to 
      correctly estimate the long-term consequences of our findings.
FAU - Vrijens, Karen
AU  - Vrijens K
AD  - Center for Environmental Sciences, Hasselt University, Diepenbeek, Belgium.
FAU - Trippas, Ann-Julie
AU  - Trippas AJ
AD  - Center for Environmental Sciences, Hasselt University, Diepenbeek, Belgium.
FAU - Lefebvre, Wouter
AU  - Lefebvre W
AD  - Flemish Institute for Technological Research (VITO), Mol, Belgium.
FAU - Vanpoucke, Charlotte
AU  - Vanpoucke C
AD  - Belgian Interregional Environment Agency (IRCELINE), Brussels, Belgium.
FAU - Penders, Joris
AU  - Penders J
AD  - Hospital East Limburg, Genk, Belgium.
FAU - Janssen, Bram G
AU  - Janssen BG
AD  - Center for Environmental Sciences, Hasselt University, Diepenbeek, Belgium.
FAU - Nawrot, Tim S
AU  - Nawrot TS
AD  - Center for Environmental Sciences, Hasselt University, Diepenbeek, Belgium.
AD  - Department of Public Health, Environment and Health Unit, Leuven University (KU 
      Leuven), Leuven, Belgium.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20200501
PL  - United States
TA  - JAMA Netw Open
JT  - JAMA network open
JID - 101729235
RN  - 0 (Histones)
SB  - IM
MH  - Adult
MH  - Air Pollution/*adverse effects
MH  - Belgium
MH  - Female
MH  - Fetal Blood/*chemistry
MH  - Histones/*blood
MH  - Humans
MH  - *Maternal Exposure
MH  - Pregnancy
MH  - Prenatal Exposure Delayed Effects
MH  - Risk Factors
PMC - PMC7235690
COIS- Conflict of Interest Disclosures: None reported.
EDAT- 2020/05/19 06:00
MHDA- 2020/10/27 06:00
PMCR- 2020/05/18
CRDT- 2020/05/19 06:00
PHST- 2020/05/19 06:00 [entrez]
PHST- 2020/05/19 06:00 [pubmed]
PHST- 2020/10/27 06:00 [medline]
PHST- 2020/05/18 00:00 [pmc-release]
AID - 2765997 [pii]
AID - zoi200244 [pii]
AID - 10.1001/jamanetworkopen.2020.5156 [doi]
PST - epublish
SO  - JAMA Netw Open. 2020 May 1;3(5):e205156. doi: 10.1001/jamanetworkopen.2020.5156.