PMID- 32421816
OWN - NLM
STAT- MEDLINE
DCOM- 20201007
LR  - 20240427
IS  - 1362-4962 (Electronic)
IS  - 0305-1048 (Print)
IS  - 0305-1048 (Linking)
VI  - 48
IP  - W1
DP  - 2020 Jul 2
TI  - FGviewer: an online visualization tool for functional features of human fusion 
      genes.
PG  - W313-W320
LID - 10.1093/nar/gkaa364 [doi]
AB  - Among the diverse location of the breakpoints (BPs) of structural variants (SVs), 
      the breakpoints of fusion genes (FGs) are located in the gene bodies. This broken 
      gene context provided the aberrant functional clues to study disease genesis. 
      Many tumorigenic fusion genes have retained or lost functional or regulatory 
      domains and these features impacted tumorigenesis. Full annotation of fusion 
      genes aided by the visualization tool based on two gene bodies will be helpful to 
      study the functional aspect of fusion genes. To date, a specialized tool with 
      effective visualization of the functional features of fusion genes is not 
      available. In this study, we built FGviewer, a tool for visualizing functional 
      features of human fusion genes, which is available at 
      https://ccsmweb.uth.edu/FGviewer. FGviewer gets the input of fusion gene symbols, 
      breakpoint information, or structural variants from whole-genome sequence (WGS) 
      data. For any combination of gene pairs/breakpoints to be involved in fusion 
      genes, the users can search the functional/regulatory aspect of the fusion gene 
      in the three bio-molecular levels (DNA-, RNA-, and protein-levels) and one 
      clinical level (pathogenic-level). FGviewer will be a unique online tool in 
      disease research communities.
CI  - (c) The Author(s) 2020. Published by Oxford University Press on behalf of Nucleic 
      Acids Research.
FAU - Kim, Pora
AU  - Kim P
AD  - School of Biomedical Informatics, The University of Texas Health Science Center 
      at Houston, Houston, TX 77030, USA.
FAU - Yiya, Ke
AU  - Yiya K
AD  - College of Electronic and Information Engineering, Tongji University, Shanghai, 
      China.
FAU - Zhou, Xiaobo
AU  - Zhou X
AD  - School of Biomedical Informatics, The University of Texas Health Science Center 
      at Houston, Houston, TX 77030, USA.
AD  - McGovern Medical School, The University of Texas Health Science Center at 
      Houston, Houston, TX 77030, USA.
AD  - School of Dentistry, The University of Texas Health Science Center at Houston, 
      Houston, TX 77030, USA.
LA  - eng
GR  - R01 CA241930/CA/NCI NIH HHS/United States
GR  - R01 GM123037/GM/NIGMS NIH HHS/United States
GR  - R35 GM138184/GM/NIGMS NIH HHS/United States
GR  - U01 AR069395/AR/NIAMS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PL  - England
TA  - Nucleic Acids Res
JT  - Nucleic acids research
JID - 0411011
RN  - 0 (Transcription Factors)
SB  - IM
MH  - Amino Acid Sequence
MH  - Computer Graphics
MH  - Disease/genetics
MH  - *Gene Fusion
MH  - Humans
MH  - *Software
MH  - Transcription Factors/metabolism
MH  - Whole Genome Sequencing
PMC - PMC7319540
EDAT- 2020/05/19 06:00
MHDA- 2020/10/08 06:00
PMCR- 2020/05/18
CRDT- 2020/05/19 06:00
PHST- 2020/04/27 00:00 [accepted]
PHST- 2020/04/17 00:00 [revised]
PHST- 2020/03/16 00:00 [received]
PHST- 2020/05/19 06:00 [pubmed]
PHST- 2020/10/08 06:00 [medline]
PHST- 2020/05/19 06:00 [entrez]
PHST- 2020/05/18 00:00 [pmc-release]
AID - 5838863 [pii]
AID - gkaa364 [pii]
AID - 10.1093/nar/gkaa364 [doi]
PST - ppublish
SO  - Nucleic Acids Res. 2020 Jul 2;48(W1):W313-W320. doi: 10.1093/nar/gkaa364.