PMID- 32421987
OWN - NLM
STAT- MEDLINE
DCOM- 20210714
LR  - 20210714
IS  - 1045-4403 (Print)
IS  - 1045-4403 (Linking)
VI  - 30
IP  - 1
DP  - 2020
TI  - Identification of Potential Core Genes in Immunoglobulin-Resistant Kawasaki 
      Disease Using Bioinformatics Analysis.
PG  - 85-91
LID - 10.1615/CritRevEukaryotGeneExpr.2020028702 [doi]
AB  - Intravenous immunoglobulin (IVIG)-resistant Kawasaki disease (KD) is a complex 
      disease, leading to the damage of multiple systems. The pathogen that triggers 
      this sophisticated disease is still unknown. The aim of this study was to 
      identify gene signatures during IVIG-resistant KD and uncover their potential 
      mechanisms. The gene expression profiles of GSE18606 were downloaded from the GEO 
      database. The GSE18606 dataset contained eight IVIG-resistant KD samples and nine 
      healthy age-appropriate controls. The gene ontology (GO) and Kyoto Encyclopedia 
      of Genes and Genomes pathway analyses were performed, and protein-protein 
      interaction (PPI) network of the differentially expressed genes (DEGs) was 
      constructed by Cytoscape software. In total, 73 DEGs were identified in 
      IVIG-resistant KD, including 58 upregulated genes and 15 downregulated genes. GO 
      analysis results showed that DEGs were significantly enriched in biological 
      processes of neutrophil degranulation, neutrophil mediated immunity, and 
      neutrophil activation involved in immune response. Among them, 10 hub genes 
      (S100A8, S100A9, S100A12, HGF, LCN2, LY96, CTGF, MMP8, IRAK3, and SLPI) with a 
      high degree of connectivity were selected. The present study indicated that the 
      identified DEGs and hub genes promote our understanding of the molecular 
      mechanisms underlying the development of IVIG-resistant KD, and might be used as 
      molecular targets and diagnostic biomarkers for the treatment of IVIG-resistant 
      KD.
FAU - Pan, Yan
AU  - Pan Y
AD  - Department of Pediatrics, The First Affiliated Hospital of Yangtze University, 
      Jingzhou, Hubei Province, China.
FAU - Fan, Qihong
AU  - Fan Q
AD  - Department of Pediatrics, The First Affiliated Hospital of Yangtze University, 
      Jingzhou, Hubei Province, China.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Crit Rev Eukaryot Gene Expr
JT  - Critical reviews in eukaryotic gene expression
JID - 9007261
RN  - 0 (Immunoglobulins, Intravenous)
SB  - IM
MH  - Child, Preschool
MH  - Computational Biology
MH  - Drug Resistance/*genetics
MH  - Female
MH  - Gene Expression Regulation/drug effects/genetics
MH  - Gene Ontology
MH  - Genome, Human/drug effects/genetics
MH  - Humans
MH  - Immunoglobulins, Intravenous/administration & dosage/*adverse effects
MH  - Infant
MH  - Male
MH  - Mucocutaneous Lymph Node Syndrome/*drug therapy/genetics/immunology
MH  - Protein Interaction Maps/drug effects/*genetics/immunology
MH  - Software
MH  - Transcriptome/genetics
EDAT- 2020/05/19 06:00
MHDA- 2021/07/15 06:00
CRDT- 2020/05/19 06:00
PHST- 2020/05/19 06:00 [entrez]
PHST- 2020/05/19 06:00 [pubmed]
PHST- 2021/07/15 06:00 [medline]
AID - 478e880265896a53,1fc0f5a93154e145 [pii]
AID - 10.1615/CritRevEukaryotGeneExpr.2020028702 [doi]
PST - ppublish
SO  - Crit Rev Eukaryot Gene Expr. 2020;30(1):85-91. doi: 
      10.1615/CritRevEukaryotGeneExpr.2020028702.