PMID- 32422966
OWN - NLM
STAT- MEDLINE
DCOM- 20210129
LR  - 20210129
IS  - 1648-9144 (Electronic)
IS  - 1010-660X (Print)
IS  - 1010-660X (Linking)
VI  - 56
IP  - 5
DP  - 2020 May 14
TI  - Could FeNO Predict Asthma in Patients with House Dust Mites Allergic Rhinitis?
LID - 10.3390/medicina56050235 [doi]
LID - 235
AB  - Background and Objectives: The evolution of allergic rhinitis to asthma is a part 
      of "atopic march". The aim of this study was to analyze possible predictive 
      markers for asthma occurrence in patients with allergic rhinitis to house dust 
      mites (HDM). Materials and Methods: Fifty-eight patients with persistent allergic 
      rhinitis (PAR) were included. The clinical, biological evaluation and 
      fractionated exhaled nitric oxide (FeNO) measurement were performed at enrolment. 
      The patients were clinically evaluated after one year to determine asthma 
      occurrence. Results: The severity of rhinitis symptoms, levels of total 
      immunoglobulin E (IgE), ICAM-1, VCAM-1, E-selectin and IL-6, but not IL-8 and 
      TNF-alpha were higher in patients with allergic rhinitis who developed asthma 
      compared to non-asthmatics, but the differences were not significant to 
      considered them as predictive factors for asthma occurrence. The risk of asthma 
      was independently influenced by patients aged over 30 years ((OR-3.74; CI95% 
      0.86-16.31; p = 0.07), a duration of allergic rhinitis over 12 months ((OR-4.20; 
      CI95% 0.88-20; p = 0.07) and a basal FeNO over 28 parts per billion (pbb) 
      ((OR-18.68; CI95% 3.79-92.05; p < 0.001). Conclusion: Clinical and biological 
      parameters may predict asthma occurrence in patients with persistent allergic 
      rhinitis to HDM. Adult patients with a longer duration of rhinitis symptoms and a 
      high level of FeNO have a greater risk to develop asthma.
FAU - Muntean, Ioana Adriana
AU  - Muntean IA
AD  - Department of Allergology and Immunology, "Iuliu Hatieganu" University of 
      Medicine and Pharmacy, 400162 Cluj Napoca, Romania.
FAU - Bocsan, Ioana Corina
AU  - Bocsan IC
AD  - Toxicology and Clinical Pharmacology, Department of Pharmacology, "Iuliu 
      Hatieganu" University of Medicine and Pharmacy, 400337 Cluj Napoca, Romania.
FAU - Vesa, Stefan
AU  - Vesa S
AUID- ORCID: 0000-0003-4549-3526
AD  - Toxicology and Clinical Pharmacology, Department of Pharmacology, "Iuliu 
      Hatieganu" University of Medicine and Pharmacy, 400337 Cluj Napoca, Romania.
FAU - Miron, Nicolae
AU  - Miron N
AD  - Department of Clinical Immunology, Sahlgrenska University Hospital, 41346 
      Goteborg, Sweden.
FAU - Nedelea, Irena
AU  - Nedelea I
AD  - Department of Allergology and Immunology, "Iuliu Hatieganu" University of 
      Medicine and Pharmacy, 400162 Cluj Napoca, Romania.
FAU - Buzoianu, Anca Dana
AU  - Buzoianu AD
AD  - Toxicology and Clinical Pharmacology, Department of Pharmacology, "Iuliu 
      Hatieganu" University of Medicine and Pharmacy, 400337 Cluj Napoca, Romania.
FAU - Deleanu, Diana
AU  - Deleanu D
AD  - Department of Allergology and Immunology, "Iuliu Hatieganu" University of 
      Medicine and Pharmacy, 400162 Cluj Napoca, Romania.
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20200514
PL  - Switzerland
TA  - Medicina (Kaunas)
JT  - Medicina (Kaunas, Lithuania)
JID - 9425208
RN  - 0 (Biomarkers)
RN  - 31C4KY9ESH (Nitric Oxide)
SB  - IM
MH  - Adult
MH  - Animals
MH  - Asthma/*diagnosis/etiology/immunology
MH  - Biomarkers/analysis
MH  - Female
MH  - Humans
MH  - Male
MH  - Nitric Oxide/*analysis
MH  - Pyroglyphidae/*immunology
MH  - Rhinitis, Allergic, Perennial/complications/*immunology
MH  - Risk Factors
PMC - PMC7279291
OTO - NOTNLM
OT  - FeNO
OT  - allergic inflammation
OT  - allergic rhinitis
OT  - asthma
OT  - house dust mites
COIS- The authors declare no conflict of interest.
EDAT- 2020/05/20 06:00
MHDA- 2021/01/30 06:00
PMCR- 2020/05/14
CRDT- 2020/05/20 06:00
PHST- 2020/04/13 00:00 [received]
PHST- 2020/04/30 00:00 [revised]
PHST- 2020/05/11 00:00 [accepted]
PHST- 2020/05/20 06:00 [entrez]
PHST- 2020/05/20 06:00 [pubmed]
PHST- 2021/01/30 06:00 [medline]
PHST- 2020/05/14 00:00 [pmc-release]
AID - medicina56050235 [pii]
AID - medicina-56-00235 [pii]
AID - 10.3390/medicina56050235 [doi]
PST - epublish
SO  - Medicina (Kaunas). 2020 May 14;56(5):235. doi: 10.3390/medicina56050235.