PMID- 32423050
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200928
IS  - 2218-1989 (Print)
IS  - 2218-1989 (Electronic)
IS  - 2218-1989 (Linking)
VI  - 10
IP  - 5
DP  - 2020 May 14
TI  - Dyslipidemia: A Trigger for Coronary Heart Disease in Romanian Patients with 
      Diabetes.
LID - 10.3390/metabo10050195 [doi]
LID - 195
AB  - Previous studies have reported age and gender disparities in the occurrence and 
      therapeutic approach of dyslipidemia and (or) coronary heart disease (CHD) in 
      patients with type 2 diabetes mellitus (T2DM). We aimed to investigate these 
      differences in Romanian patients with T2DM. A cross-sectional, observational, 
      retrospective study was conducted using the medical records of T2DM patients who 
      attended the outpatient facility of the Internal Medicine Clinic of the Clinical 
      Emergency Hospital of Bucharest, Romania for routine check-ups in a six-month 
      period. We analyzed the records of 217 diabetic patients (mean age 69 +/- 11 years; 
      51.15% women). We found no significant gender differences in the occurrence of 
      dyslipidemia, CHD or CHD + dyslipidemia or in terms of statin prescription. 
      However; patients aged 65 years or older were significantly more affected by 
      dyslipidemia, CHD or CHD + dyslipidemia, versus subjects aged <65 years. Further, 
      they were more likely to be prescribed statin therapy (p < 0.0001 for all). 
      Statins were prescribed to 67.24% of the patients with dyslipidemia; 61.01% of 
      the subjects with CHD; and to 91.48% of the patients who had both conditions. e 
      recorded no gender differences in the occurrence of CHD and (or) dyslipidemia in 
      Romanian T2DM patients. Patients aged 65 years or older had a higher prevalence 
      of CHD and/or dyslipidemia, and were more likely to be prescribed statins, versus 
      younger counterparts. However, many T2DM patients with CHD and (or) dyslipidemia 
      were undertreated: Nearly 33% of the subjects with dyslipidemia, and nearly 40% 
      of the ones with CHD were not prescribed statins.
FAU - Gaman, Mihnea-Alexandru
AU  - Gaman MA
AUID- ORCID: 0000-0001-7133-8875
AD  - Faculty of Medicine, "Carol Davila" University of Medicine and Pharmacy, 8 Eroii 
      Sanitari Boulevard, 050474 Bucharest, Romania.
AD  - Center of Hematology and Bone Marrow Transplantation, Fundeni Clinical Institute, 
      258 Fundeni Road, 022328 Bucharest, Romania.
FAU - Cozma, Matei-Alexandru
AU  - Cozma MA
AUID- ORCID: 0000-0002-4998-0105
AD  - Faculty of Medicine, "Carol Davila" University of Medicine and Pharmacy, 8 Eroii 
      Sanitari Boulevard, 050474 Bucharest, Romania.
FAU - Dobrica, Elena-Codruta
AU  - Dobrica EC
AD  - Faculty of Medicine, "Carol Davila" University of Medicine and Pharmacy, 8 Eroii 
      Sanitari Boulevard, 050474 Bucharest, Romania.
FAU - Bacalbasa, Nicolae
AU  - Bacalbasa N
AD  - Faculty of Medicine, "Carol Davila" University of Medicine and Pharmacy, 8 Eroii 
      Sanitari Boulevard, 050474 Bucharest, Romania.
AD  - Department of Visceral Surgery, Fundeni Clinical Institute, 258 Fundeni Road, 
      022328 Bucharest, Romania.
FAU - Bratu, Ovidiu Gabriel
AU  - Bratu OG
AUID- ORCID: 0000-0001-6837-260X
AD  - Faculty of Medicine, "Carol Davila" University of Medicine and Pharmacy, 8 Eroii 
      Sanitari Boulevard, 050474 Bucharest, Romania.
AD  - Urology Clinic, Carol Davila University Emergency Central Emergency Military 
      Hospital, 88 Mircea Vulcanescu Street, 010825 Bucharest, Romania.
AD  - Academy of Romanian Scientists, 54 Splaiul Independentei, 050085 Bucharest, 
      Romania.
FAU - Diaconu, Camelia Cristina
AU  - Diaconu CC
AD  - Faculty of Medicine, "Carol Davila" University of Medicine and Pharmacy, 8 Eroii 
      Sanitari Boulevard, 050474 Bucharest, Romania.
AD  - Internal Medicine Clinic, Clinical Emergency Hospital of Bucharest, 8 Calea 
      Floreasca, 014461 Bucharest, Romania.
LA  - eng
PT  - Journal Article
DEP - 20200514
PL  - Switzerland
TA  - Metabolites
JT  - Metabolites
JID - 101578790
PMC - PMC7280968
OTO - NOTNLM
OT  - coronary heart disease
OT  - diabetes
OT  - dyslipidemia
OT  - ischemic heart disease
OT  - statins
COIS- The authors declare no conflict of interest.
EDAT- 2020/05/20 06:00
MHDA- 2020/05/20 06:01
PMCR- 2020/05/01
CRDT- 2020/05/20 06:00
PHST- 2020/01/19 00:00 [received]
PHST- 2020/05/10 00:00 [revised]
PHST- 2020/05/12 00:00 [accepted]
PHST- 2020/05/20 06:00 [entrez]
PHST- 2020/05/20 06:00 [pubmed]
PHST- 2020/05/20 06:01 [medline]
PHST- 2020/05/01 00:00 [pmc-release]
AID - metabo10050195 [pii]
AID - metabolites-10-00195 [pii]
AID - 10.3390/metabo10050195 [doi]
PST - epublish
SO  - Metabolites. 2020 May 14;10(5):195. doi: 10.3390/metabo10050195.