PMID- 32423229
OWN - NLM
STAT- MEDLINE
DCOM- 20210215
LR  - 20210215
IS  - 1600-0455 (Electronic)
IS  - 0284-1851 (Linking)
VI  - 62
IP  - 2
DP  - 2021 Feb
TI  - Abnormal functional connectivity and effective connectivity between the default 
      mode network and attention networks in patients with alcohol-use disorder.
PG  - 251-259
LID - 10.1177/0284185120923270 [doi]
AB  - BACKGROUND: Patients with alcohol-use disorder (AUD) demonstrate dysfunctional 
      cerebral network connectivity. However, limited studies have investigated 
      attention systems in AUD. PURPOSE: To assess functional (FC) and effective 
      connectivity (EC) in the dorsal (DAN) and ventral attention networks (VAN) and 
      default mode network (DMN) in patients with AUD using resting-state functional 
      magnetic resonance imaging (rs-fMRI). MATERIAL AND METHODS: MRI and rs-fMRI data 
      were obtained from 28 men with AUD and 30 age-matched healthy controls. 
      Independent component analysis was used to identify and extract network data, for 
      comparison between the two groups. Effective connectivity was evaluated using 
      Granger causality analysis (GCA) by selecting significantly different brain areas 
      as regions of interest (ROI). Signed-path coefficients between ROIs were computed 
      in bivariate mode. RESULTS: In patients with AUD, FC decreased in the left 
      superior parietal gurus (SPG) and left interparietal sulcus (IPS, in DAN); FC 
      decreased in the right superior frontal gyrus (SPG) and right middle frontal 
      gyrus (MFG, in DMN). GCA values indicated that the DMN exerts a positive causal 
      effect on the DAN (P = 0.007/0.027), which consequently exerts a negative causal 
      effect on the DMN (P = 0.032). Signed-path coefficients from the right MFG to the 
      left IPS correlated negatively with MAST scores (P = 0.015). CONCLUSION: We found 
      novel inter-network connectivity dysfunction in patients with AUD, which 
      indicates abnormal causal relations between resting-state DAN and DMN. Thus, 
      patients with AUD may have abnormal top-down attention modulation and cognition.
FAU - Song, Zhiyan
AU  - Song Z
AUID- ORCID: 0000-0001-9973-858X
AD  - Department of Radiology, Renmin Hospital of 12390Wuhan University, Wuhan, PR 
      China.
FAU - Chen, Jun
AU  - Chen J
AD  - Department of Radiology, Renmin Hospital of 12390Wuhan University, Wuhan, PR 
      China.
FAU - Wen, Zhi
AU  - Wen Z
AD  - Department of Radiology, Renmin Hospital of 12390Wuhan University, Wuhan, PR 
      China.
FAU - Zhang, Lei
AU  - Zhang L
AD  - Department of Radiology, Renmin Hospital of 12390Wuhan University, Wuhan, PR 
      China.
LA  - eng
PT  - Journal Article
DEP - 20200518
PL  - England
TA  - Acta Radiol
JT  - Acta radiologica (Stockholm, Sweden : 1987)
JID - 8706123
SB  - IM
MH  - Adult
MH  - Alcoholism/diagnosis/*physiopathology
MH  - Attention
MH  - Brain/*diagnostic imaging/*physiopathology
MH  - Brain Mapping/methods
MH  - Default Mode Network/*diagnostic imaging/*physiopathology
MH  - Humans
MH  - Magnetic Resonance Imaging/*methods
MH  - Male
MH  - Middle Aged
OTO - NOTNLM
OT  - Central nervous system
OT  - adults
OT  - functional magnetic resonance imaging
EDAT- 2020/05/20 06:00
MHDA- 2021/02/16 06:00
CRDT- 2020/05/20 06:00
PHST- 2020/05/20 06:00 [pubmed]
PHST- 2021/02/16 06:00 [medline]
PHST- 2020/05/20 06:00 [entrez]
AID - 10.1177/0284185120923270 [doi]
PST - ppublish
SO  - Acta Radiol. 2021 Feb;62(2):251-259. doi: 10.1177/0284185120923270. Epub 2020 May 
      18.