PMID- 32423495
OWN - NLM
STAT- MEDLINE
DCOM- 20220110
LR  - 20220110
IS  - 1092-8529 (Print)
IS  - 1092-8529 (Linking)
VI  - 26
IP  - 4
DP  - 2021 Aug
TI  - Plasma redox and inflammatory patterns during major depressive episodes: a 
      cross-sectional investigation in elderly patients with mood disorders.
PG  - 416-426
LID - 10.1017/S1092852920001443 [doi]
AB  - BACKGROUND: While both depression and aging have been associated with oxidative 
      stress and impaired immune response, little is known about redox patterns in 
      elderly depressed subjects. This study investigates the relationship between 
      redox/inflammatory patterns and depression in a sample of elderly adults. 
      METHODS: The plasma levels of the advanced products of protein oxidation (AOPP), 
      catalase (CAT), ferric reducing antioxidant power (FRAP), glutathione transferase 
      (GST), interleukin 6 (IL-6), superoxide dismutase (SOD), total thiols (TT), and 
      uric acid (UA) were evaluated in 30 patients with mood disorders with a current 
      depressive episode (depressed patients, DP) as well as in 30 healthy controls 
      (HC) aged 65 years and over. Subjects were assessed with the Hamilton Depression 
      Rating Scale (HAM-D), the Hamilton Rating Scale for Anxiety (HAM-A), the 
      Geriatric Depression Rating Scale (GDS), the Scale for Suicide Ideation (SSI), 
      the Reason for Living Inventory (RFL), the Activities of Daily Living (ADL), and 
      the Instrumental Activity of Daily Living (IADL). RESULTS: DP showed higher 
      levels than HC of AOPP and IL-6, while displaying lower levels of FRAP, TT, and 
      CAT. In the DP group, specific correlations were found among biochemical 
      parameters. SOD, FRAP, UA, and TT levels were also significantly related to 
      psychometric scale scores. CONCLUSION: Specific alterations of redox systems are 
      detectable among elderly DP.
FAU - Carpita, Barbara
AU  - Carpita B
AUID- ORCID: 0000-0002-2806-6736
AD  - Department of Clinical and Experimental Medicine, University of Pisa, Pisa, 
      Italy.
FAU - Betti, Laura
AU  - Betti L
AD  - Department of Pharmacy, University of Pisa, Pisa, Italy.
FAU - Palego, Lionella
AU  - Palego L
AD  - Department of Clinical and Experimental Medicine, University of Pisa, Pisa, 
      Italy.
FAU - Bartolommei, Natalia
AU  - Bartolommei N
AD  - Department of Clinical and Experimental Medicine, University of Pisa, Pisa, 
      Italy.
FAU - Chico, Lucia
AU  - Chico L
AD  - Department of Clinical and Experimental Medicine, University of Pisa, Pisa, 
      Italy.
FAU - Pasquali, Livia
AU  - Pasquali L
AD  - Department of Clinical and Experimental Medicine, University of Pisa, Pisa, 
      Italy.
FAU - Siciliano, Gabriele
AU  - Siciliano G
AD  - Department of Clinical and Experimental Medicine, University of Pisa, Pisa, 
      Italy.
FAU - Monzani, Fabio
AU  - Monzani F
AD  - Department of Clinical and Experimental Medicine, University of Pisa, Pisa, 
      Italy.
FAU - Franchi, Riccardo
AU  - Franchi R
AD  - Department of Clinical and Experimental Medicine, University of Pisa, Pisa, 
      Italy.
FAU - Rogani, Sara
AU  - Rogani S
AD  - Department of Clinical and Experimental Medicine, University of Pisa, Pisa, 
      Italy.
FAU - Mucci, Federico
AU  - Mucci F
AD  - Department of Clinical and Experimental Medicine, University of Pisa, Pisa, 
      Italy.
FAU - Elefante, Camilla
AU  - Elefante C
AD  - Department of Clinical and Experimental Medicine, University of Pisa, Pisa, 
      Italy.
FAU - Lattanzi, Lorenzo
AU  - Lattanzi L
AD  - Department of Clinical and Experimental Medicine, University of Pisa, Pisa, 
      Italy.
FAU - Marazziti, Donatella
AU  - Marazziti D
AUID- ORCID: 0000-0002-4021-5829
AD  - Department of Clinical and Experimental Medicine, University of Pisa, Pisa, 
      Italy.
FAU - Giannaccini, Gino
AU  - Giannaccini G
AD  - Department of Pharmacy, University of Pisa, Pisa, Italy.
FAU - Dell'Osso, Liliana
AU  - Dell'Osso L
AD  - Department of Clinical and Experimental Medicine, University of Pisa, Pisa, 
      Italy.
LA  - eng
PT  - Journal Article
DEP - 20200519
PL  - United States
TA  - CNS Spectr
JT  - CNS spectrums
JID - 9702877
RN  - 0 (Interleukin-6)
RN  - EC 1.11.1.6 (Catalase)
RN  - EC 1.15.1.1 (Superoxide Dismutase)
RN  - EC 2.5.1.18 (Glutathione Transferase)
SB  - IM
MH  - Activities of Daily Living/psychology
MH  - Aged
MH  - Aged, 80 and over
MH  - Catalase/*blood
MH  - Depressive Disorder, Major/*blood/psychology
MH  - Female
MH  - Glutathione Transferase/*blood
MH  - Humans
MH  - Inflammation/blood
MH  - Interleukin-6/*blood
MH  - Male
MH  - Oxidation-Reduction
MH  - Psychiatric Status Rating Scales
MH  - Suicidal Ideation
MH  - Superoxide Dismutase/*blood
OTO - NOTNLM
OT  - Depression
OT  - antioxidative systems
OT  - biochemical markers
OT  - biological psychiatry
OT  - geriatric
EDAT- 2020/05/20 06:00
MHDA- 2022/01/11 06:00
CRDT- 2020/05/20 06:00
PHST- 2020/05/20 06:00 [pubmed]
PHST- 2022/01/11 06:00 [medline]
PHST- 2020/05/20 06:00 [entrez]
AID - S1092852920001443 [pii]
AID - 10.1017/S1092852920001443 [doi]
PST - ppublish
SO  - CNS Spectr. 2021 Aug;26(4):416-426. doi: 10.1017/S1092852920001443. Epub 2020 May 
      19.