PMID- 32424689 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20201030 IS - 2193-8261 (Print) IS - 2193-6544 (Electronic) IS - 2193-6544 (Linking) VI - 9 IP - 2 DP - 2020 Dec TI - The Physiologic Basis and Clinical Outcomes of Combined Impella and Veno-Arterial Extracorporeal Membrane Oxygenation Support in Cardiogenic Shock. PG - 245-255 LID - 10.1007/s40119-020-00175-6 [doi] AB - Veno-arterial extracorporeal membrane oxygenation (VA-ECMO) provides effective hemodynamic support in cardiogenic shock, but in some cases may be complicated by left ventricular (LV) distension and pulmonary edema. The Impella, a catheter-mounted microaxial pump has been used to unload the LV. Recent studies have compared the clinical outcomes of VA-ECMO to the combination of Impella and VA-ECMO. The purpose of this review is threefold: firstly, to discuss the physiological effects of Impella support in addition to VA-ECMO, secondly to review published studies on the outcome of this combined support, and thirdly to provide a practical overview of the approach to combining Impella and VA-ECMO. FAU - Lim, Hoong Sern AU - Lim HS AD - University Hospital Birmingham, Edgbaston, Birmingham, UK. sern.lim@uhb.nhs.uk. LA - eng PT - Journal Article PT - Review DEP - 20200518 PL - England TA - Cardiol Ther JT - Cardiology and therapy JID - 101634495 PMC - PMC7584716 OTO - NOTNLM OT - Cardiogenic shock OT - Extracorporeal membrane oxygenation OT - Physiology EDAT- 2020/05/20 06:00 MHDA- 2020/05/20 06:01 PMCR- 2020/05/18 CRDT- 2020/05/20 06:00 PHST- 2020/04/15 00:00 [received] PHST- 2020/05/20 06:00 [pubmed] PHST- 2020/05/20 06:01 [medline] PHST- 2020/05/20 06:00 [entrez] PHST- 2020/05/18 00:00 [pmc-release] AID - 10.1007/s40119-020-00175-6 [pii] AID - 175 [pii] AID - 10.1007/s40119-020-00175-6 [doi] PST - ppublish SO - Cardiol Ther. 2020 Dec;9(2):245-255. doi: 10.1007/s40119-020-00175-6. Epub 2020 May 18.