PMID- 32425978
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200928
IS  - 1664-8021 (Print)
IS  - 1664-8021 (Electronic)
IS  - 1664-8021 (Linking)
VI  - 11
DP  - 2020
TI  - High-Resolution HLA Typing of HLA-A, -B, -C, -DRB1, and -DQB1 in Kinh Vietnamese 
      by Using Next-Generation Sequencing.
PG  - 383
LID - 10.3389/fgene.2020.00383 [doi]
LID - 383
AB  - Human leukocyte antigen (HLA) genotyping displays the particular characteristics 
      of HLA alleles and haplotype frequencies in each population. Although it is 
      considered the current gold standard for HLA typing, high-resolution 
      sequence-based HLA typing is currently unavailable in Kinh Vietnamese 
      populations. In this study, high-resolution sequence-based HLA typing (3-field) 
      was performed using an amplicon-based next-generation sequencing platform to 
      identify the HLA-A, -B, -C, -DRB1, and -DQB1 alleles of 101 unrelated healthy 
      Kinh Vietnamese individuals from southern Vietnam. A total of 28 HLA-A, 41 HLA-B, 
      21 HLA-C, 26 HLA-DRB1, and 25 HLA-DQB1 alleles were identified. The most 
      frequently occurring HLA alleles were A( *)11:01:01, B( *)15:02:01, C( *)07:02:01, 
      DRB1( *)12:02:01, and DQB1( *)03:01:01. Haplotype calculation showed that 
      A( *)29:01:01 approximately B( *)07:05:01, DRB1( *)12:02:01 approximately DQB1( *)3:01:01, 
      A( *)29:01:01 approximately C( *)15:05:02 approximately B( *)07:05:01, 
      A( *)33:03:01 approximately B( *)58:01:01 approximately DRB1( *)03:01:01, and 
      A( *)29:01:01 approximately C( *)15:05:02 approximately B( *)07:05:01 approximately DRB1( *)10:01:01 approximately DQB1( *)05:01:01 were the 
      most common haplotypes in the southern Kinh Vietnamese population. Allele 
      distribution and haplotype analyses demonstrated that the Vietnamese population 
      shares HLA features with South-East Asians but retains unique characteristics. 
      Data from this study will be potentially applicable in medicine and anthropology.
CI  - Copyright (c) 2020 Do, Le, Nguyen, Dang, Nguyen, Vu and Mai.
FAU - Do, Minh Duc
AU  - Do MD
AD  - Center for Molecular Biomedicine, University of Medicine and Pharmacy at Ho Chi 
      Minh City, Ho Chi Minh City, Vietnam.
FAU - Le, Linh Gia Hoang
AU  - Le LGH
AD  - Center for Molecular Biomedicine, University of Medicine and Pharmacy at Ho Chi 
      Minh City, Ho Chi Minh City, Vietnam.
FAU - Nguyen, Vinh The
AU  - Nguyen VT
AD  - Center for Molecular Biomedicine, University of Medicine and Pharmacy at Ho Chi 
      Minh City, Ho Chi Minh City, Vietnam.
FAU - Dang, Tran Ngoc
AU  - Dang TN
AD  - Faculty of Public Health, University of Medicine and Pharmacy at Ho Chi Minh 
      City, Ho Chi Minh City, Vietnam.
FAU - Nguyen, Nghia Hoai
AU  - Nguyen NH
AD  - Center for Molecular Biomedicine, University of Medicine and Pharmacy at Ho Chi 
      Minh City, Ho Chi Minh City, Vietnam.
FAU - Vu, Hoang Anh
AU  - Vu HA
AD  - Center for Molecular Biomedicine, University of Medicine and Pharmacy at Ho Chi 
      Minh City, Ho Chi Minh City, Vietnam.
FAU - Mai, Thao Phuong
AU  - Mai TP
AD  - Department of Physiology, Pathophysiology and Immunology, Faculty of Medicine, 
      University of Medicine and Pharmacy at Ho Chi Minh City, Ho Chi Minh City, 
      Vietnam.
LA  - eng
PT  - Journal Article
DEP - 20200430
PL  - Switzerland
TA  - Front Genet
JT  - Frontiers in genetics
JID - 101560621
PMC - PMC7204072
OTO - NOTNLM
OT  - HLA typing
OT  - Kinh Vietnamese
OT  - allele frequency
OT  - haplotype frequency
OT  - high-resolution
OT  - next-generation sequencing
EDAT- 2020/05/20 06:00
MHDA- 2020/05/20 06:01
PMCR- 2020/04/30
CRDT- 2020/05/20 06:00
PHST- 2019/11/07 00:00 [received]
PHST- 2020/03/27 00:00 [accepted]
PHST- 2020/05/20 06:00 [entrez]
PHST- 2020/05/20 06:00 [pubmed]
PHST- 2020/05/20 06:01 [medline]
PHST- 2020/04/30 00:00 [pmc-release]
AID - 10.3389/fgene.2020.00383 [doi]
PST - epublish
SO  - Front Genet. 2020 Apr 30;11:383. doi: 10.3389/fgene.2020.00383. eCollection 2020.