PMID- 32428988
OWN - NLM
STAT- MEDLINE
DCOM- 20210621
LR  - 20210621
IS  - 1447-0756 (Electronic)
IS  - 1341-8076 (Linking)
VI  - 46
IP  - 7
DP  - 2020 Jul
TI  - Prenatal nicotine exposure affects cardiovascular function and growth of the 
      developing fetus.
PG  - 1044-1054
LID - 10.1111/jog.14294 [doi]
AB  - AIM: Effects of nicotine on fetal hemodynamics are not well known, especially in 
      the first trimester fetus. We investigated the acute and chronic effects of 
      nicotine on hemodynamics in pregnant mice and their fetuses using ultrasound. 
      Postnatal health status including growth and hemodynamics was also examined. 
      METHODS: To investigate the acute effects of nicotine on fetal hemodynamics, we 
      injected nicotine 0.2 mg/kg subcutaneously into pregnant mice on gestational days 
      (GD) 9.5, 11.5 and 13.5 and compared with saline-injected group. To determine the 
      chronic effects of nicotine on fetal hemodynamics, we administered nicotine in 
      drinking water (0.1 mg/mL) to pregnant mice from GD 6.5 until they gave birth and 
      compared hemodynamics with water-administered mice. RESULTS: Regarding the acute 
      effects of nicotine, we found no intergroup difference in maternal hemodynamics; 
      however, fetal blood flow through the dorsal aorta, carotid artery and umbilical 
      artery tended to decrease, particularly on GD 11.5. Regarding the chronic effects 
      of nicotine, we observed no intergroup difference in maternal body weight changes 
      and hemodynamics; however, blood flow to all fetal organs tended to be lower in 
      the nicotine water group than in the water group with significant difference on 
      GD 13.5. The offspring of the nicotine water group had significantly low birth 
      weights and continued to have low body weight until 9 weeks of age. In addition, 
      these offspring developed postnatal cardiac hypertrophy. CONCLUSION: Nicotine 
      adversely affects fetal hemodynamics acutely and chronically in early pregnancy, 
      potentially leading to fetal tissue hypoxia, intrauterine growth restriction and 
      adverse postnatal health effects.
CI  - (c) 2020 Japan Society of Obstetrics and Gynecology.
FAU - Aoyagi, Yoshimichi
AU  - Aoyagi Y
AUID- ORCID: 0000-0003-0801-8603
AD  - Department of Pediatrics, Fukushima Medical University, Fukushima, Japan.
FAU - Momoi, Nobuo
AU  - Momoi N
AD  - Department of Pediatrics, Fukushima Medical University, Fukushima, Japan.
FAU - Kanai, Yuji
AU  - Kanai Y
AD  - Department of Pediatrics, Fukushima Medical University, Fukushima, Japan.
FAU - Go, Hayato
AU  - Go H
AD  - Department of Pediatrics, Fukushima Medical University, Fukushima, Japan.
FAU - Abe, Yusaku
AU  - Abe Y
AD  - Department of Pediatrics, Fukushima Medical University, Fukushima, Japan.
FAU - Miyazaki, Kyohei
AU  - Miyazaki K
AD  - Department of Pediatrics, Fukushima Medical University, Fukushima, Japan.
FAU - Tomita, Yoichi
AU  - Tomita Y
AD  - Department of Pediatrics, Fukushima Medical University, Fukushima, Japan.
FAU - Hayashi, Mariko
AU  - Hayashi M
AD  - Department of Pediatrics, Fukushima Medical University, Fukushima, Japan.
FAU - Endo, Kisei
AU  - Endo K
AD  - Department of Pediatrics, Fukushima Medical University, Fukushima, Japan.
FAU - Mitomo, Masaki
AU  - Mitomo M
AD  - Department of Pediatrics, Fukushima Medical University, Fukushima, Japan.
FAU - Hosoya, Mitsuaki
AU  - Hosoya M
AD  - Department of Pediatrics, Fukushima Medical University, Fukushima, Japan.
LA  - eng
PT  - Journal Article
DEP - 20200519
PL  - Australia
TA  - J Obstet Gynaecol Res
JT  - The journal of obstetrics and gynaecology research
JID - 9612761
RN  - 6M3C89ZY6R (Nicotine)
SB  - IM
MH  - Animals
MH  - Female
MH  - Fetal Growth Retardation/chemically induced
MH  - *Fetus
MH  - Hemodynamics
MH  - Mice
MH  - *Nicotine
MH  - Pregnancy
MH  - Umbilical Arteries
OTO - NOTNLM
OT  - fetus
OT  - hemodynamics
OT  - neonate
OT  - nicotine
EDAT- 2020/05/20 06:00
MHDA- 2021/06/22 06:00
CRDT- 2020/05/20 06:00
PHST- 2019/11/30 00:00 [received]
PHST- 2020/03/29 00:00 [revised]
PHST- 2020/04/19 00:00 [accepted]
PHST- 2020/05/20 06:00 [pubmed]
PHST- 2021/06/22 06:00 [medline]
PHST- 2020/05/20 06:00 [entrez]
AID - 10.1111/jog.14294 [doi]
PST - ppublish
SO  - J Obstet Gynaecol Res. 2020 Jul;46(7):1044-1054. doi: 10.1111/jog.14294. Epub 
      2020 May 19.