PMID- 32429361
OWN - NLM
STAT- MEDLINE
DCOM- 20210129
LR  - 20231111
IS  - 1648-9144 (Electronic)
IS  - 1010-660X (Print)
IS  - 1010-660X (Linking)
VI  - 56
IP  - 5
DP  - 2020 May 16
TI  - Determination of Referential Rates for Optical Coherence Tomography and Optical 
      Coherence Tomography Angiography Flow Deficits in the Macular Choriocapillaris in 
      Ophthalmologically Healthy Children.
LID - 10.3390/medicina56050238 [doi]
LID - 238
AB  - Background and Objectives: Despite the growing number of new research 
      publications, normative references for children's optical coherence tomography 
      (OCT) parameters are still not completed. We chose to explore this topic because 
      of the lack of normative parameters that is due to an improvement in different 
      technologies and instruments. Our aim was to determine referential rates of 
      retinal nerve fiber layer (RNFL) thickness and flow deficits (FD%) in the macular 
      choriocapillaris (CC) in normal eyes of ophthalmologically healthy children. 
      Materials and Methods: Ophthalmologically healthy 8- to 14-year-old individuals 
      participated (n = 75) in this study. OCT images were taken using an 
      swept-source-OCT (SS-OCT) instrument (DRI-OCT Triton, Topcon, Tokyo, Japan). The 
      early treatment diabetic retinopathy study (EDTRS) grid (6 x 6 mm) divided the 
      RNFL into the thickness maps. The FD% values of the CC were calculated on the 3 x 
      3-mm scans in a 1-mm circle (C(1)), 1.5-mm rim (R(1.5)), and the entire 2.5-mm 
      circle (C(2.5)), and on the 6 x 6-mm scans in a 1-mm circle (C(1)), 1.5-mm rim 
      (R(1.5)), the entire 2.5-mm circle (C(2.5)), 2.5-mm rim (R(2.5)), and 5-mm circle 
      (C(5)). Results: Both scan quantifications of FD% in the C(1), C(2.5), and R(1.5) 
      sectors were similar, but the 6 x 6-mm scan measurements were statistically 
      significantly smaller than the 3 x 3-mm ones. Significant moderate correlations 
      were found between axial length (AxL) and FD% in the 6 x 6-mm scans, namely C(1) 
      (r = -0.347, p = 0.002), C(2.5) (r = -0.337, p = 0.003), R(1.5) (r = -0.328, p = 
      0.004), R(2.5) (r = -0.306, p = 0.008), and C(5) (r = -0.314, p = 0.006). 
      Conclusions: The thinnest RNFL layers were on the temporal and nasal sides. FD% 
      values in the C(1), C(2.5), and R(1.5) sectors were similar between the 3 x 3-mm 
      and 6 x 6-mm scans. The negative moderate correlations between AxL and FD% were 
      found in all C(1), C(2.5), C(5,) R(1.5), and R(2.5) sectors of the 6 x 6-mm 
      scans. Further prospective studies are needed to determine more accurate 
      normative references for children's OCT parameters.
FAU - Bakstyte, Viktorija
AU  - Bakstyte V
AD  - Faculty of Medicine, Medical Academy, Lithuanian University of Health Sciences, 
      LT-44307 Kaunas, Lithuania.
FAU - Sniureviciute, Liveta
AU  - Sniureviciute L
AD  - Faculty of Medicine, Medical Academy, Lithuanian University of Health Sciences, 
      LT-44307 Kaunas, Lithuania.
FAU - Simiene, Evelina
AU  - Simiene E
AD  - Department of Ophthalmology, Hospital of Lithuanian University of Health Sciences 
      Kaunas Clinics, LT-50162 Kaunas, Lithuania.
FAU - Skruodyte, Justina
AU  - Skruodyte J
AD  - Department of Ophthalmology, Hospital of Lithuanian University of Health Sciences 
      Kaunas Clinics, LT-50162 Kaunas, Lithuania.
FAU - Januleviciene, Ingrida
AU  - Januleviciene I
AD  - Department of Ophthalmology, Hospital of Lithuanian University of Health Sciences 
      Kaunas Clinics, LT-50162 Kaunas, Lithuania.
LA  - eng
PT  - Journal Article
DEP - 20200516
PL  - Switzerland
TA  - Medicina (Kaunas)
JT  - Medicina (Kaunas, Lithuania)
JID - 9425208
SB  - IM
MH  - Angiography
MH  - Child
MH  - Choroid/*anatomy & histology/diagnostic imaging
MH  - Cross-Sectional Studies
MH  - Female
MH  - Humans
MH  - Male
MH  - Optic Disk/anatomy & histology/diagnostic imaging
MH  - Prospective Studies
MH  - Reference Values
MH  - Retina/*anatomy & histology/diagnostic imaging
MH  - Retinal Ganglion Cells/physiology
MH  - Tomography, Optical Coherence/*methods
PMC - PMC7279138
OTO - NOTNLM
OT  - choriocapillaris
OT  - flow deficits
OT  - ophthalmologically healthy children
OT  - optical coherence tomography angiography
OT  - retinal nerve fiber layer
OT  - swept-source optical coherence tomography
COIS- The authors declare no conflict of interest.
EDAT- 2020/05/21 06:00
MHDA- 2021/01/30 06:00
PMCR- 2020/05/16
CRDT- 2020/05/21 06:00
PHST- 2020/03/21 00:00 [received]
PHST- 2020/05/07 00:00 [revised]
PHST- 2020/05/13 00:00 [accepted]
PHST- 2020/05/21 06:00 [entrez]
PHST- 2020/05/21 06:00 [pubmed]
PHST- 2021/01/30 06:00 [medline]
PHST- 2020/05/16 00:00 [pmc-release]
AID - medicina56050238 [pii]
AID - medicina-56-00238 [pii]
AID - 10.3390/medicina56050238 [doi]
PST - epublish
SO  - Medicina (Kaunas). 2020 May 16;56(5):238. doi: 10.3390/medicina56050238.