PMID- 32429656
OWN - NLM
STAT- MEDLINE
DCOM- 20200908
LR  - 20200908
IS  - 1233-9687 (Print)
IS  - 1233-9687 (Linking)
VI  - 71
IP  - 1
DP  - 2020
TI  - Differences in GATA3 expression among histological/molecular subtypes and grades 
      in infiltrating breast carcinoma (IBC) are important in the diagnosis of 
      metastatic breast carcinoma.
PG  - 62-65
LID - 40698 [pii]
LID - 10.5114/pjp.2020.95417 [doi]
AB  - GATA-binding protein 3 (GATA3) is a sensitive and relatively specific marker in 
      invasive breast carcinomas (IBC). The aim of the present study was to determine 
      GATA3 expression among different histological and surrogate molecular breast 
      carcinoma subtypes. Immunohistochemical staining of ER, PR, Ki67, HER2 and GATA3 
      was performed in a cohort of 84 consecutive cases of primary IBCs. The 
      association of GATA3 expression with different histological subtypes, grades and 
      surrogate intrinsic molecular subtypes was assessed. The overall positivity of 
      GATA3 across various histological subtypes was 71.43% with no correlation with 
      histological type (p = 0.849). Our study also confirmed that GATA3 exhibits a 
      relatively high sensitivity for IBC (78.57%). GATA3 expression was positively 
      correlated with low histological grades (G1/G2) vs. G3: p = 0.001) with most of 
      G3 (57.89%) cases being negative and with luminal A (72.22%) and B (84.62%) 
      subtypes (p = 0.00001) while most of the triple negative (87.5%) and 
      HER2-overexpressed (66.67%) being negative. Caution must be payed however when 
      dealing with an IBC metastasis of HER2-overexpressed or triple negative molecular 
      subtypes or G3, since in these categories according to the present study, GATA3 
      is more frequently negative that previously reported and may be useless for 
      diagnosis of tumor origin.
FAU - Stolnicu, Simona
AU  - Stolnicu S
AD  - Department of Pathology, University of Medicine, Pharmacy, Sciences and 
      Technology (UMFTS) of Targu Mures, Romania.
FAU - Tunde, Csillip
AU  - Tunde C
AD  - Department of Pathology, University of Medicine, Pharmacy, Sciences and 
      Technology (UMFTS) of Targu Mures, Romania.
FAU - Cadar, Ana
AU  - Cadar A
AD  - Department of Pathology, University of Medicine, Pharmacy, Sciences and 
      Technology (UMFTS) of Targu Mures, Romania.
FAU - Boros, Monica
AU  - Boros M
AD  - Department of Pathology, Faculty of Medicine and Pharmacy, University of Oradea, 
      Romania.
LA  - eng
PT  - Journal Article
PL  - Poland
TA  - Pol J Pathol
JT  - Polish journal of pathology : official journal of the Polish Society of 
      Pathologists
JID - 9437432
RN  - 0 (Biomarkers, Tumor)
RN  - 0 (GATA3 Transcription Factor)
RN  - 0 (GATA3 protein, human)
SB  - IM
MH  - Biomarkers, Tumor/genetics
MH  - Breast Neoplasms/*diagnosis/genetics
MH  - GATA3 Transcription Factor/*genetics
MH  - Humans
MH  - Neoplasm Metastasis
OTO - NOTNLM
OT  - GATA3
OT  - histologic
OT  - molecular subtypes
OT  - infiltrating breast carcinoma
EDAT- 2020/05/21 06:00
MHDA- 2020/09/09 06:00
CRDT- 2020/05/21 06:00
PHST- 2020/05/21 06:00 [entrez]
PHST- 2020/05/21 06:00 [pubmed]
PHST- 2020/09/09 06:00 [medline]
AID - 40698 [pii]
AID - 10.5114/pjp.2020.95417 [doi]
PST - ppublish
SO  - Pol J Pathol. 2020;71(1):62-65. doi: 10.5114/pjp.2020.95417.